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AACompSim tool


AACompSim is a tool which allows the comparison of the amino acid composition of a UniProtKB/Swiss-Prot entry with all other UniProtKB/Swiss-Prot entries so as to find the proteins whose amino acid compositions are closest to that of the selected entry [references].
Documentation is available.
You will have to enter the following data:
  1. A UniProtKB/Swiss-Prot identifier (ID) (e.g. ALBU_HUMAN) or UniProtKB/Swiss-Prot accession number (AC) (e.g. P04406).
  2. Your e-mail address. The search results will be mailed back to you automatically (this should take less than 15 minutes).
  3. The UniProtKB/Swiss-Prot abbreviation for the species for which you would like to perform the search (example: HUMAN). This will produce the list of proteins from this species, as well as a list of proteins independently of species; you may also specify ALL for all UniProtKB/Swiss-Prot entries.
Few amino acid analysis techniques produce composition results for all amino acids. We currently have indexed UniProtKB/Swiss-Prot for the following constellations. Please choose one of them:
  1. Constellation 0: ALL amino acids: Ala, Ile, Pro, Val, Arg, Leu, Ser, Thr, Gly, Met, His, Phe, Tyr, Lys, Asp, Asn, Gln, Glu, Cys and Trp.
  2. Constellation 1: Ala, Ile, Pro, Val, Arg, Leu, Ser, Asx, Thr, Glx, Gly, Met, His, Phe and Tyr.
    (Asp+Asn=Asx; Gln+Glu=Glx; Lys, Cys and Trp are not considered).
  3. Constellation 2: Ala, Ile, Pro, Val, Arg, Leu, Ser, Asx, Lys, Thr, Glx, Gly, Met, His, Phe and Tyr.
    (Asp+Asn=Asx; Gln+Glu=Glx; Cys and Trp are not considered).