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Cellosaurus ACH-2 (CVCL_0138)

[Text version]
Cell line name ACH-2
Synonyms ACH2
Accession CVCL_0138
Resource Identification Initiative To cite this cell line use: ACH-2 (RRID:CVCL_0138)
Comments Population: Caucasian.
Virology: Latently infected with HIV-1 isolate LAI. The main site of integration of the HIV-1 genome is located in the NT5C3A gene. Additional integration sites are found in the SLC25A25-AS, EPT1 and NPLOC4 genes (PubMed=26912621; PubMed=28086908).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6244 (CEM A3.01)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=2463307; DOI=10.4049/jimmunol.142.2.431
Clouse K.A., Powell D., Washington I., Poli G., Strebel K., Farrar W.L., Barstad P., Kovacs J., Fauci A.S., Folks T.M.
Monokine regulation of human immunodeficiency virus-1 expression in a chronically infected human T cell clone.
J. Immunol. 142:431-438(1989)

PubMed=26912621; DOI=10.1128/JVI.01617-15
Sunshine S., Kirchner R., Amr S.S., Mansur L., Shakhbatyan R., Kim M., Bosque A., Siliciano R.F., Planelles V., Hofmann O., Sui S.H., Li J.Z.
HIV integration site analysis of cellular models of HIV latency with a probe-enriched next-generation sequencing assay.
J. Virol. 90:4511-4519(2016)

PubMed=28086908; DOI=10.1186/s12977-016-0325-2
Symons J., Chopra A., Malatinkova E., De Spiegelaere W., Leary S., Cooper D., Abana C.O., Rhodes A., Rezaei S.D., Vandekerckhove L., Mallal S., Lewin S.R., Cameron P.U.
HIV integration sites in latently infected cell lines: evidence of ongoing replication.
Retrovirology 14:2.1-2.11(2017)

Cross-references
Cell line collections (Providers) HIVReagentProgram; ARP-349
Cell line databases/resources MCCL; MCC:0000031
cancercelllines; CVCL_0138
Anatomy/cell type resources BTO; BTO:0002551
Chemistry resources ChEMBL-Cells; CHEMBL3307897
ChEMBL-Targets; CHEMBL614263
PubChem_Cell_line; CVCL_0138
Encyclopedic resources Wikidata; Q54608362
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number15