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Cellosaurus SK-N-BE(2)-M17 (CVCL_0167)

[Text version]
Cell line name SK-N-BE(2)-M17
Synonyms BE(2)-M17; BE(2)M17; BE(2)M-17; BE2-M17; BE2M17
Accession CVCL_0167
Resource Identification Initiative To cite this cell line use: SK-N-BE(2)-M17 (RRID:CVCL_0167)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK1980-531.
Population: Caucasian.
Characteristics: Neuroblastic type (N-type) (PubMed=15720811).
Doubling time: 20-24 hours (ECACC=95011816).
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Array-based CGH.
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys135Phe (c.404G>T); ClinVar=VCV000376559; Zygosity=Heterozygous (Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.92
Native American1.22
East Asian, North3.24
East Asian, South0
South Asian6.24
European, North21.38
European, South64
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0528 (SK-N-BE(2))
Sex of cell Male
Age at sampling 2Y2M
Category Cancer cell line
STR profile Source(s): ATCC; CCRID; Cosmic-CLP; ECACC; JCRB; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10
D2S133817,23 (PubMed=25877200)
23 (CCRID)
D3S135819
D5S81812
D7S8209,10
D8S117913,14
D13S31711
D16S5399,11 (CCRID)
11 (ATCC; Cosmic-CLP; ECACC; JCRB; PubMed=25877200)
D18S5114 (PubMed=25877200)
16,26 (CCRID)
D19S43312,13
D21S1130,32.2
FGA22,25
Penta D13,14
Penta E14,18
TH016
TPOX8,11 (ATCC; Cosmic-CLP; ECACC; JCRB; PubMed=25877200)
11 (CCRID)
vWA17,18 (Cosmic-CLP; JCRB)
18 (ATCC; CCRID; ECACC; PubMed=25877200)

Run an STR similarity search on this cell line
Web pages https://www.mskcc.org/research-advantage/support/technology/tangible-material/sk-n-be-2-m17-human-neuroblastoma-cell-line
Publications

PubMed=2535691
Ciccarone V., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A.
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.
Cancer Res. 49:219-225(1989)

PubMed=10485488
Glick R.D., Swendeman S.L., Coffey D.C., Rifkind R.A., Marks P.A., Richon V.M., La Quaglia M.P.
Hybrid polar histone deacetylase inhibitor induces apoptosis and CD95/CD95 ligand expression in human neuroblastoma.
Cancer Res. 59:4392-4399(1999)

PubMed=15720811; DOI=10.1593/neo.04310
Walton J.D., Kattan D.R., Thomas S.K., Spengler B.A., Guo H.-F., Biedler J.L., Cheung N.-K.V., Ross R.A.
Characteristics of stem cells from human neuroblastoma cell lines and in tumors.
Neoplasia 6:838-845(2004)

PubMed=15892104; DOI=10.1002/gcc.20198
Mosse Y.P., Greshock J., Margolin A.A., Naylor T., Cole K., Khazi D., Hii G., Winter C., Shahzad S., Asziz M.U., Biegel J.A., Weber B.L., Maris J.M.
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=17506115; DOI=10.1002/nbm.1181
Peet A.C., McConville C.M., Wilson M.P., Levine B.A., Reed M., Dyer S.A., Edwards E.C., Strachan M.C., McMullan D.J., Wilkes T.M., Grundy R.G.
1H MRS identifies specific metabolite profiles associated with MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell lines.
NMR Biomed. 20:692-700(2007)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26342562; DOI=10.1016/j.scr.2015.08.008
Ross R.A., Walton J.D., Han D., Guo H.-F., Cheung N.-K.V.
A distinct gene expression signature characterizes human neuroblastoma cancer stem cells.
Stem Cell Res. 15:419-426(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-2267
ECACC; 95011816
JCRB; JCRB9131 - Discontinued
JCRB; NIHS0221 - Discontinued
NCBI_Iran; C614
Cell line databases/resources CLO; CLO_0001916
MCCL; MCC:0000059
CLDB; cl407
cancercelllines; CVCL_0167
CCRID; 1101HUM-PUMC000076
Cell_Model_Passport; SIDM01229
Cosmic-CLP; 753616
DepMap; ACH-002217
LINCS_LDP; LCL-1972
Lonza; 1236
Anatomy/cell type resources BTO; BTO:0002104
Biological sample resources BioSample; SAMN03471024
BioSample; SAMN03472366
CRISP screens repositories BioGRID_ORCS_Cell_line; 833
Chemistry resources ChEMBL-Cells; CHEMBL4295394
ChEMBL-Targets; CHEMBL4296494
GDSC; 753616
PharmacoDB; BE2M17_85_2019
PubChem_Cell_line; CVCL_0167
Encyclopedic resources Wikidata; Q54954446
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669614
Polymorphism and mutation databases Cosmic; 753616
Cosmic; 1167416
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number36