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Cellosaurus C6 (CVCL_0194)

Cell line name C6
Synonyms C-6; C 6; RGC-6; RGC6; RGc6
Accession CVCL_0194
Secondary accession CVCL_4060
Resource Identification Initiative To cite this cell line use: C6 (RRID:CVCL_0194)
Comments Doubling time: 14.75 hours (PubMed=2303324); 24-28 hours (DOI=10.5005/jp-journals-10082-02230); ~24 hours (CLS=500142); ~25-30 hours (DSMZ=ACC-550).
Transformant: ChEBI; CHEBI:50102; N-methyl-N-nitrosourea (NMU).
Omics: Deep quantitative proteome analysis.
Omics: Mitochondrial genome sequenced.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Disease Rat malignant glioma (NCIt: C64069)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Wistar Furth.
Hierarchy Children:
CVCL_ZB60 (C6 rho-0#14)CVCL_1970 (C6-BU-1)CVCL_6336 (C6-SF2)
CVCL_4V35 (C6/ACNU)CVCL_C9FG (C6/Cas9-hyg)CVCL_5657 (C6/lacZ)
CVCL_B7TS (C6rho0)CVCL_5H90 (C6TK-)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-129.html
Publications

CLPUB00233
Lightbody J.
Establishment of differentiated clonal strains of glial brain cells in culture.
Fed. Proc. 27:720-720(1968)

PubMed=4873531; DOI=10.1126/science.161.3839.370
Benda P., Lightbody J., Sato G.H., Levine L., Sweet W.H.
Differentiated rat glial cell strain in tissue culture.
Science 161:370-371(1968)

DOI=10.1007/BF02618370
Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.
The animal cell culture collection.
In Vitro 5:1-16(1970)

PubMed=3468959
Yoshida T., Shimizu K., Ushio Y., Mogami H., Sakamoto Y.
Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma.
No To Shinkei 38:1065-1070(1986)

PubMed=2303323
Brauner T., Schmid A., Hulser D.F.
Tumor cell invasion and gap junctional communication. I. Normal and malignant cells confronted in monolayer cultures.
Invasion Metastasis 10:18-30(1990)

PubMed=2303324
Brauner T., Hulser D.F.
Tumor cell invasion and gap junctional communication. II. Normal and malignant cells confronted in multicell spheroids.
Invasion Metastasis 10:31-48(1990)

PubMed=19381449; DOI=10.1007/s11060-009-9875-7
Barth R.F., Kaur B.
Rat brain tumor models in experimental neuro-oncology: the C6, 9L, T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomas.
J. Neurooncol. 94:299-312(2009)

PubMed=25492533; DOI=10.3109/19401736.2014.982619
Gao J., Hu L., Peng H.-H., Shi J.-G.
The complete mitochondrial genome sequence of the rat C6 glioma cell line.
Mitochondrial DNA 27:2188-2189(2016)

DOI=10.5005/jp-journals-10082-02230
Kuduvalli S.S., Ramalakshmi O., Precilla S.D., Anitha T.S.
Evaluation of cell doubling time in C6 and Y79 cell lines based on seeding density.
SBV J. Basic Clin. Appl. Heatlh Sci. 2:146-149(2019)

PubMed=34917708; DOI=10.1016/j.dib.2021.107658
Silantyev A.S., Bukato O.N., Butenko I.O., Chernysheva A.A., Pobeguts O.V., Nosyrev A.E., Gurina O.I.
Proteomic dataset: profiling of glioma C6 and astrocytes rat cell lines before and after co-cultivation.
Data Brief 39:107658.1-107658.9(2021)

Cross-references
Cell line collections (Providers) ATCC; CCL-107
BCRC; 60046
BCRJ; 0057
CLS; 500142
DSMZ; ACC-550
ECACC; 92090409
ICLC; ATL95007
IZSLER; BS TCL 5
JCRB; IFO50110
JCRB; JCRB9096
KCB; KCB 93026YJ
KCLB; 10107
NCBI_Iran; C575
RCB; RCB2783
RCB; RCB2854
TKG; TKG 0242
TKG; TKG 0589
Cell line databases/resources CLO; CLO_0002072
CLO; CLO_0002140
CLO; CLO_0051387
CLO; CLO_0051388
MCCL; MCC:0000085
CLDB; cl579
CLDB; cl580
CLDB; cl581
CLDB; cl583
CLDB; cl5165
CCRID; 1101RAT-PUMC000131
CCRID; 1102RAT-NIFDC00048
CCRID; 3101RATTCR1
DSMZCellDive; ACC-550
Lonza; 27
TOKU-E; 750
Anatomy/cell type resources BTO; BTO:0000529
Chemistry resources ChEMBL-Cells; CHEMBL3308345
ChEMBL-Targets; CHEMBL614657
PubChem_Cell_line; CVCL_0194
Encyclopedic resources Wikidata; Q54808212
Proteomic databases PRIDE; PXD026776
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number31