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Cellosaurus FL5.12 (CVCL_0262)

Cell line name FL5.12
Synonyms FL5.12A; Fetal Liver clone 5.12
Accession CVCL_0262
Resource Identification Initiative To cite this cell line use: FL5.12 (RRID:CVCL_0262)
Comments Characteristics: IL3 dependent.
Derived from site: In situ; Embryonic liver; UBERON=UBERON_0002107.
Cell type: Pro-B cell; CL=CL_0000826.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/c.
Hierarchy Children:
CVCL_HE70 (FL5.12 Bax CL16)CVCL_C4LY (FL5.12 Bcl-XL)
Sex of cell Sex unspecified
Age at sampling 13FD
Category Factor-dependent cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=FL5%2e12
https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/f/cell-lines-detail-468.html
Publications

PubMed=3933007; DOI=10.1073/pnas.82.21.7414
McKearn J.P., McCubrey J.A., Fagg B.
Enrichment of hematopoietic precursor cells and cloning of multipotential B-lymphocyte precursors.
Proc. Natl. Acad. Sci. U.S.A. 82:7414-7418(1985)

PubMed=8358790; DOI=10.1016/0092-8674(93)90509-O
Oltvai Z.N., Milliman C.L., Korsmeyer S.J.
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.
Cell 74:609-619(1993)

PubMed=8798452; DOI=10.1074/jbc.271.37.22764
Simonian P.L., Grillot D.A.M., Merino R., Nunez G.
Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL.
J. Biol. Chem. 271:22764-22772(1996)

PubMed=10200549; DOI=10.1038/sj.cdd.4400452
Bojes H.K., Feng X., Kehrer J.P., Cohen G.M.
Apoptosis in hematopoietic cells (FL5.12) caused by interleukin-3 withdrawal: relationship to caspase activity and the loss of glutathione.
Cell Death Differ. 6:61-70(1999)

PubMed=11486081; DOI=10.1126/science.1061075
Devireddy L.R., Teodoro J.G., Richard F.A., Green M.R.
Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation.
Science 293:829-834(2001)

Cross-references
Cell line databases/resources MCCL; MCC:0000153
Lonza; 259
Anatomy/cell type resources BTO; BTO:0003328
CRISP screens repositories BioGRID_ORCS_Cell_line; 1592
Chemistry resources ChEMBL-Cells; CHEMBL4295395
ChEMBL-Targets; CHEMBL4296414
PubChem_Cell_line; CVCL_0262
Encyclopedic resources Wikidata; Q54834972
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number17