Cellosaurus logo
expasy logo

Cellosaurus HEC-1-B (CVCL_0294)

[Text version]
Cell line name HEC-1-B
Synonyms Hec-1-B; HEC-1B; Hec-1b; HEC1-B; HEC1B; Hec1B
Accession CVCL_0294
Resource Identification Initiative To cite this cell line use: HEC-1-B (RRID:CVCL_0294)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
Population: Japanese.
Microsatellite instability: Instable (MSI) (PubMed=31068700).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (DepMap).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Heterozygous (DepMap).
  • Mutation; HGNC; 7329; MSH6; Simple; c.4001+1G>T; ClinVar=VCV001736936; Zygosity=Heterozygous; Note=Splice donor mutation (DepMap).
  • Mutation; HGNC; 9122; PMS2; Simple; p.Arg802Ter (c.2404C>T); ClinVar=VCV000009237; Zygosity=Heterozygous (DepMap).
  • Mutation; HGNC; 9588; PTEN; None_reported; -; Zygosity=- (PubMed=20944090).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.76
East Asian, North92.48
East Asian, South6.76
South Asian0
European, North0
European, South0
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0293 (HEC-1-A)
Children:
CVCL_XC84 (HEC-1-B-Cas9-580)CVCL_XC85 (HEC-1-B-Cas9-581)CVCL_XC86 (HEC-1-B-Cas9-582)
CVCL_XC87 (HEC-1-B-Cas9-583)CVCL_XC88 (HEC-1-B-Cas9-584)CVCL_XC89 (HEC-1-B-Cas9-585)
CVCL_XC90 (HEC-1-B-Cas9-586)CVCL_XC91 (HEC-1-B-Cas9-587)CVCL_XC92 (HEC-1-B-Cas9-588)
CVCL_XC93 (HEC-1-B-Cas9-589)CVCL_XC94 (HEC-1-B-Cas9-590)CVCL_XC95 (HEC-1-B-Cas9-591)
CVCL_XC96 (HEC-1-B-Cas9-592)CVCL_YJ46 (HEC-1BE)
Sex of cell Female
Age at sampling 71Y
Category Cancer cell line
STR profile Source(s): ATCC; CCRID; JCRB; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D2S133818,19
D3S135815
D5S81811,13
D7S8209,11
D8S117913,14
D13S31711 (JCRB; PubMed=25877200)
11,16 (ATCC; CCRID)
D16S53911,12
D18S5116,20
D19S43313
D21S1130,31
FGA21
Penta D9,13
Penta E11
TH016 (PubMed=25877200)
6,7 (ATCC; CCRID; JCRB)
TPOX8,11
vWA18

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=4678779
Kuramoto H.
Studies of the growth and cytogenetic properties of human endometrial adenocarcinoma in culture and its development into an established line.
Acta Obstet. Gynaecol. Jpn. 19:47-58(1972)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6163305
Sekiya S., Takamizawa H.
Effect of anticancer drugs on in vitro survival of cell lines derived from various gynecologic tumors.
Nihon Sanka Fujinka Gakkai Zasshi 33:373-376(1981)

PubMed=6174649
Sekiya S., Kawata M., Inaba N., Takamizawa H.
Studies on marker substances in cell lines derived from various human gynecologic tumors.
Nihon Sanka Fujinka Gakkai Zasshi 34:37-42(1982)

PubMed=6220172
Dracopoli N.C., Fogh J.
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=12227503; DOI=10.1111/j.1749-0774.2002.tb00103.x
Kuramoto H., Hamano M., Imai M.
HEC-1 cells.
Hum. Cell 15:81-95(2002)

DOI=10.1007/978-4-431-53981-0_1
Kuramoto H., Hamano M., Imai M., Fujisawa T., Kamata Y., Arai T., Kawaguchi M.
HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.
(In) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo (2003)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20218740; DOI=10.1177/153303461000900207
Wang Y.-M., Yang D., Cogdell D., Hu L.-M., Xue F.-X., Broaddus R., Zhang W.
Genomic characterization of gene copy-number aberrations in endometrial carcinoma cell lines derived from endometrioid-type endometrial adenocarcinoma.
Technol. Cancer Res. Treat. 9:179-189(2010)

PubMed=20944090; DOI=10.1126/scitranslmed.3001538
Dedes K.J., Wetterskog D., Mendes-Pereira A.M., Natrajan R., Lambros M.B., Geyer F.C., Vatcheva R., Savage K., Mackay A., Lord C.J., Ashworth A., Reis-Filho J.S.
PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.
Sci. Transl. Med. 2:53ra75.1-53ra75.8(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ATCC; HTB-113
CCTCC; GDC0129
CLS; 305095
JCRB; JCRB1193
JCRB; NIHS0480 - Discontinued
KCB; KCB 200551YJ
Ubigene; YC-C108
Cell line databases/resources CLO; CLO_0003675
MCCL; MCC:0000184
CLDB; cl1582
cancercelllines; CVCL_0294
CCRID; 1101HUM-PUMC000105
CCRID; 3101HUMTCHu115
CCRID; 4201HUM-CCTCC00129
Cell_Model_Passport; SIDM01241
DepMap; ACH-000941
IGRhCellID; HEC1B
Anatomy/cell type resources BTO; BTO:0003038
Biological sample resources BioSample; SAMN03471094
BioSample; SAMN03472427
BioSample; SAMN03473077
BioSample; SAMN10987737
CRISP screens repositories BioGRID_ORCS_Cell_line; 420
Chemistry resources ChEMBL-Cells; CHEMBL3308662
ChEMBL-Targets; CHEMBL614817
PharmacoDB; HEC1B_532_2019
PubChem_Cell_line; CVCL_0294
Encyclopedic resources Wikidata; Q54882253
Experimental variables resources EFO; EFO_0002192
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-2770
GEO; GSM844557
GEO; GSM887070
GEO; GSM888140
Polymorphism and mutation databases Cosmic; 687552
Cosmic; 809131
Cosmic; 846178
Cosmic; 980635
Cosmic; 1070807
Cosmic; 1177621
Cosmic; 1223486
Cosmic; 1241345
Cosmic; 1576458
Cosmic; 1696757
Cosmic; 2030465
IARC_TP53; 1111
LiGeA; CCLE_480
Progenetix; CVCL_0294
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number35