Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST.
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

Cellosaurus IB3-1 (CVCL_0338)

Cell line name IB3-1
Synonyms IB3
Accession CVCL_0338
Resource Identification Initiative To cite this cell line use: IB3-1 (RRID:CVCL_0338)
Comments Sequence variation: Heterozygous for CFTR p.Phe508del and p.Trp1282Ter (PubMed=15463957).
Transformant: Ad12-SV40.
Omics: Proteome analysis by 2D-DE/MS.
Disease Cystic fibrosis (NCIt: C2975)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4462 (IB3-1/C38)CVCL_4461 (IB3-1/S9)
Sex of cell Male
Category Transformed cell line
STR profile Source(s): ATCC

Web pages http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/i/cell-lines-detail-527.html

PubMed=1849726; DOI=10.1165/ajrcmb/4.4.313
Zeitlin P.L., Lu L., Rhim J.S., Cutting G., Stetten G., Kieffer K.A., Craig R., Guggino W.B.
A cystic fibrosis bronchial epithelial cell line: immortalization by adeno-12-SV40 infection.
Am. J. Respir. Cell Mol. Biol. 4:313-319(1991)

PubMed=1380129; DOI=10.1038/358581a0
Egan M., Flotte T.R., Afione S.A., Solow R., Zeitlin P.L., Carter B.J., Guggino W.B.
Defective regulation of outwardly rectifying Cl- channels by protein kinase A corrected by insertion of CFTR.
Nature 358:581-584(1992)

Flotte T.R., Afione S.A., Solow R., Drumm M.L., Markakis D., Guggino W.B., Zeitlin P.L., Carter B.J.
Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter.
J. Biol. Chem. 268:3781-3790(1993)

PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040
Gruenert D.C., Willems M., Cassiman J.J., Frizzell R.A.
Established cell lines used in cystic fibrosis research.
J. Cyst. Fibros. 3:191-196(2004)

PubMed=16512671; DOI=10.1021/pr050319o
Singh O.V., Vij N., Mogayzel P.J. Jr., Jozwik C., Pollard H.B., Zeitlin P.L.
Pharmacoproteomics of 4-phenylbutyrate-treated IB3-1 cystic fibrosis bronchial epithelial cells.
J. Proteome Res. 5:562-571(2006)

PubMed=18441018; DOI=10.1194/jlr.M700388-JLR200
Andersson C., Al-Turkmani M.R., Savaille J.E., Alturkmani R., Katrangi W., Cluette-Brown J.E., Zaman M.M., Laposata M., Freedman S.D.
Cell culture models demonstrate that CFTR dysfunction leads to defective fatty acid composition and metabolism.
J. Lipid Res. 49:1692-1700(2008)

Cell line collections ATCC; CRL-2777 - Discontinued
ATCC; JHU-52 - Discontinued
BCRJ; 0114
Ontologies BTO; BTO:0004445
CLO; CLO_0004329
EFO; EFO_0001194
MCCL; MCC:0000234