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Cellosaurus Jurkat clone A3 (CVCL_1061)

[Text version]
Cell line name Jurkat clone A3
Synonyms A3
Accession CVCL_1061
Resource Identification Initiative To cite this cell line use: Jurkat clone A3 (RRID:CVCL_1061)
Comments Population: Caucasian.
Omics: Metabolome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0065 (Jurkat)
Children:
CVCL_3724 (I 2.1)CVCL_3725 (I 9.2)CVCL_HF44 (Jurkat-FADD-/-)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S8189
D7S8208,10
D13S3178,11
D16S53911
TH016,9.3
TPOX8,10
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=8972182; DOI=10.1128/mcb.17.1.24
Juo P., Kuo C.J., Reynolds S.E., Konz R.F., Raingeaud J., Davis R.J., Biemann H.-P., Blenis J.
Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases.
Mol. Cell. Biol. 17:24-35(1997)

PubMed=10616904
Juo P., Woo M.S.-A., Kuo C.J., Signorelli P., Biemann H.-P., Hannun Y.A., Blenis J.
FADD is required for multiple signaling events downstream of the receptor Fas.
Cell Growth Differ. 10:797-804(1999)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5
Leo I.R., Aswad L., Stahl M., Kunold E., Post F., Erkers T., Struyf N., Mermelekas G., Joshi R.N., Gracia-Villacampa E., Ostling P., Kallioniemi O.-P., Pokrovskaja Tamm K., Siavelis I., Lehtio J., Vesterlund M., Jafari R.
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-2570
BCRC; 60485
CLS; 305143
KCB; KCB 2010084YJ
Cell line databases/resources CLO; CLO_0001577
cancercelllines; CVCL_1061
CCRID; 3101HUMTCHu96
Cell_Model_Passport; SIDM01243
LINCS_LDP; LCL-1026
Anatomy/cell type resources BTO; BTO:0001342
Biological sample resources BioSample; SAMN03471678
Encyclopedic resources Wikidata; Q54606726
Gene expression databases GEO; GSM5137705
Metabolomic databases MetaboLights; MTBLS226
Proteomic databases PRIDE; PXD023662
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number29