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Cellosaurus ACN (CVCL_1068)

[Text version]
Cell line name ACN
Accession CVCL_1068
Resource Identification Initiative To cite this cell line use: ACN (RRID:CVCL_1068)
Comments Problematic cell line: Probably contaminated. The STR profile of ACN and LN-464 are identical. SNP analysis (DepMap) also shows identity of both cell lines. We believe this is a melanoma cell line based on the presence of the BRAF V600E mutation as well as the RNASeq expression profile of LN-464 (DepMap) which clusters with that of melanoma patient samples. Originally thought to originate from the bone marrow of a 36-month old boy with a metastatic adrenal stage-IV neuroblastoma.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Asn184fs*6 (c.545_546insA); Zygosity=Heterozygous (Cosmic-CLP; DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Phe113Ser (c.338T>C); ClinVar=VCV000823709; Zygosity=Homozygous (Cosmic-CLP; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.3
Native American0.69
East Asian, North0
East Asian, South0.16
South Asian1.02
European, North70.67
European, South27.16
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_B7TC (ACN/IFN-gamma)CVCL_B7TD (ACN/neo)
Originate from same individual CVCL_3962 ! LN-464
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; ICLC

Markers:
AmelogeninX
CSF1PO11
D3S135816
D5S81812
D7S82010,13
D8S117912,13
D13S31711,13
D16S53911
D18S5116
D21S1128
FGA22
Penta D9
Penta E10,14
TH019
TPOX9,12
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=2467885; DOI=10.1002/ijc.2910430421
Gross N., Beck D., Portoukalian J., Favre S., Carrel S.
New anti-GD2 monoclonal antibodies produced from gamma-interferon-treated neuroblastoma cells.
Int. J. Cancer 43:665-671(1989)

PubMed=1354203; DOI=10.1002/ijc.2910520116
Gross N., Favre S., Beck D., Meyer M.
Differentiation-related expression of adhesion molecules and receptors on human neuroblastoma tissues, cell lines and variants.
Int. J. Cancer 52:85-91(1992)

PubMed=8509230; DOI=10.1002/ijc.2910540329
Rimoldi D., Romero P., Carrel S.
The human melanoma antigen-encoding gene, MAGE-1, is expressed by other tumour cells of neuroectodermal origin such as glioblastomas and neuroblastomas.
Int. J. Cancer 54:527-528(1993)

DOI=10.1007/0-306-46872-7_2
Thiele C.J.
Neuroblastoma.
(In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999)

PubMed=15150552; DOI=10.1038/sj.bjc.6601842
Airoldi I., Meazza R., Croce M., Di Carlo E., Piazza T., Cocco C., D'Antuono T., Pistoia V., Ferrini S., Corrias M.V.
Low-dose interferon-gamma-producing human neuroblastoma cells show reduced proliferation and delayed tumorigenicity.
Br. J. Cancer 90:2210-2218(2004)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections (Providers) ICLC; HTL96020
Cell line databases/resources CLO; CLO_0001655
CLDB; cl239
cancercelllines; CVCL_1068
Cell_Model_Passport; SIDM00057
Cosmic-CLP; 906803
DepMap; ACH-002389
LINCS_LDP; LCL-1982
Chemistry resources ChEMBL-Cells; CHEMBL3308148
ChEMBL-Targets; CHEMBL2366195
GDSC; 906803
PharmacoDB; ACN_55_2019
PubChem_Cell_line; CVCL_1068
Encyclopedic resources Wikidata; Q54608539
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669594
Polymorphism and mutation databases Cosmic; 906803
IARC_TP53; 21170
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number32