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Cellosaurus COLO 824 (CVCL_1136)

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Cell line name COLO 824
Synonyms COLO-824; Colo-824; Colo 824; COLO #824; COLO824; Colo824; Colorado 824
Accession CVCL_1136
Resource Identification Initiative To cite this cell line use: COLO 824 (RRID:CVCL_1136)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: GrayJW breast cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Population: African American.
Doubling time: ~60-80 hours (DSMZ=ACC-200).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Caution: Previously erroneously indicated as originating from a male patient, correct sex assignment from Moore G.E. in a personal communication to the authors of PubMed=9892114.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Genome ancestry Source: PubMed=30894373

Origin% genome
African85.4
Native American0.04
East Asian, North1.28
East Asian, South0
South Asian0
European, North5.62
European, South7.67
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): CLS; Cosmic-CLP; DepMap; DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,11,12 (DepMap; DSMZ)
10,12 (CLS; Cosmic-CLP; PubMed=25877200)
D2S133821
D3S135816,17
D5S81812
D7S8207,7.3,8,11 (DepMap)
7.3,8,11 (DSMZ)
7.9,8,11 (PubMed=25877200)
8,11 (CLS; Cosmic-CLP)
D8S117912,14
D13S31711,12,13
D16S53912,13 (DSMZ)
13 (CLS; Cosmic-CLP; DepMap; PubMed=25877200)
D18S5115,18,19 (DSMZ)
15,19 (CLS; DepMap; PubMed=25877200)
D19S43315
D21S1128
FGA22
Penta D5,10
Penta E7
TH017,9
TPOX6,11
vWA16

Run an STR similarity search on this cell line
Web pages https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
https://tcpaportal.org/mclp/
Publications

PubMed=9892114; DOI=10.1002/(SICI)1098-2264(199901)24:1<87::AID-GCC13>3.0.CO;2-5
Savelyeva L., Claas A., An H.-X., Weber R.G., Lichter P., Schwab M.
Retention of polysomy at 9p23-24 during karyotypic evolution in human breast cancer cell line COLO 824.
Genes Chromosomes Cancer 24:87-93(1999)

PubMed=10969801
Forozan F., Mahlamaki E.H., Monni O., Chen Y.-D., Veldman R., Jiang Y., Gooden G.C., Ethier S.P., Kallioniemi A., Kallioniemi O.-P.
Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data.
Cancer Res. 60:4519-4525(2000)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C.B., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y.-L., Mills G.B., Cho R.J., Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) CLS; 300463
DSMZ; ACC-200
Cell line databases/resources CLO; CLO_0002577
CLDB; cl870
cancercelllines; CVCL_1136
Cell_Model_Passport; SIDM00954
Cosmic-CLP; 906812
DepMap; ACH-001820
DSMZCellDive; ACC-200
LINCS_LDP; LCL-1477
Biological sample resources BioSample; SAMN03471347
BioSample; SAMN03473374
CRISP screens repositories BioGRID_ORCS_Cell_line; 850
Chemistry resources ChEMBL-Cells; CHEMBL3308725
ChEMBL-Targets; CHEMBL1075430
GDSC; 906812
PharmacoDB; COLO824_237_2019
PubChem_Cell_line; CVCL_1136
Encyclopedic resources Wikidata; Q54814156
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM718287
GEO; GSM783979
GEO; GSM847249
GEO; GSM847459
GEO; GSM843492
GEO; GSM843493
GEO; GSM1669694
Polymorphism and mutation databases Cosmic; 906812
IARC_TP53; 21245
Progenetix; CVCL_1136
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number37