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Cellosaurus CRO-AP2 (CVCL_1147)

Cell line name CRO-AP2
Synonyms CRO-AP/2; CROAP2; AP2
Accession CVCL_1147
Resource Identification Initiative To cite this cell line use: CRO-AP2 (RRID:CVCL_1147)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Population: Caucasian.
Doubling time: ~20-40 hours (DSMZ=ACC-48).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Transformant: NCBI_TaxID; 37296; Human herpesvirus 8 (HHV-8/KSHV).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
HLA typing Source: DSMZCellDive=ACC-48
Class I
HLA-AA*68:02:01,68:02:01
HLA-BB*15:01:01,15:01:01
HLA-CC*03:03:01,07:04:01
Class II
HLA-DPDPA1*01:03:01,02:01:01
DPB1*03:01:01,10:01:01
HLA-DQDQA1*03:01:01,03:01:01
DQB1*03:02:01,05:01:01
HLA-DRDRA*01:01:01,01:02:02
DRB1*04:02:01,14:54:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.25
Native American0.15
East Asian, North0.73
East Asian, South0.29
South Asian5.13
European, North44.53
European, South48.9
Disease Primary effusion lymphoma (NCIt: C6915)
Primary effusion lymphoma (ORDO: Orphanet_48686)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 49Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX
CSF1PO11,12
D2S133818,23
D3S135816
D5S81812
D7S82010,11
D8S117913,14
D13S31711
D16S53911
D18S5112,14
D19S43314
D21S1129,31.2
FGA20,23
Penta D10,13
Penta E12
TH016,8
TPOX10,11
vWA17,18

Run an STR similarity search on this cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=CRO-AP%2f2
Publications

PubMed=9389573; DOI=10.1002/(SICI)1097-0215(19971114)73:4<562::AID-IJC18>3.0.CO;2-B
Carbone A., Cilia A.M., Gloghini A., Canzonieri V., Pastore C., Todesco M., Cozzi M., Perin T., Volpe R., Pinto A., Gaidano G.
Establishment of HHV-8-positive and HHV-8-negative lymphoma cell lines from primary lymphomatous effusions.
Int. J. Cancer 73:562-569(1997)

PubMed=9766492; DOI=10.1038/sj.leu.2401160
Drexler H.G., Uphoff C.C., Gaidano G., Carbone A.
Lymphoma cell lines: in vitro models for the study of HHV-8+ primary effusion lymphomas (body cavity-based lymphomas).
Leukemia 12:1507-1517(1998)

PubMed=10784388; DOI=10.3109/10428190009148391
Carbone A., Cilia A.M., Gloghini A., Capello D., Perin T., Bontempo D., Canzonieri V., Tirelli U., Volpe R., Gaidano G.
Primary effusion lymphoma cell lines harbouring human herpesvirus type-8.
Leuk. Lymphoma 36:447-456(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20454443; DOI=10.1155/2010/904767
Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010)

PubMed=21685375; DOI=10.1182/blood-2010-12-323659
Roy D., Sin S.-H., Damania B., Dittmer D.P.
Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.
Blood 118:E32-E39(2011)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-48
Cell line databases/resources CLO; CLO_0002617
CLDB; cl3486
cancercelllines; CVCL_1147
Cell_Model_Passport; SIDM00952
Cosmic-CLP; 906807
DepMap; ACH-002220
DSMZCellDive; ACC-48
IGRhCellID; CROAP2
Anatomy/cell type resources BTO; BTO:0002724
Biological sample resources BioSample; SAMN03473560
Chemistry resources ChEMBL-Cells; CHEMBL3308254
ChEMBL-Targets; CHEMBL2366080
GDSC; 906807
PharmacoDB; CROAP2_264_2019
PubChem_Cell_line; CVCL_1147
Encyclopedic resources Wikidata; Q54814506
Experimental variables resources EFO; EFO_0002145
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM634729
GEO; GSM1669709
Polymorphism and mutation databases Cosmic; 906807
IARC_TP53; 21257
Progenetix; CVCL_1147
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number36