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Cellosaurus IMR-5 (CVCL_1306)

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Cell line name IMR-5
Synonyms IMR 5; IMR5; IMR-05; Institute for Medical Research-5
Accession CVCL_1306
Resource Identification Initiative To cite this cell line use: IMR-5 (RRID:CVCL_1306)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Abdomen; UBERON=UBERON_0000916.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.86
East Asian, North0
East Asian, South0.06
South Asian4.46
European, North75.37
European, South19.24
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0346 (IMR-32)
Children:
CVCL_M473 (IMR-5/75)CVCL_M472 (IMR-5/M-1)CVCL_RT17 (IMR-5rCARBO5000)
CVCL_RR56 (IMR-5rCDDP1000)CVCL_RS59 (IMR-5rDACARB20)CVCL_ZX19 (IMR-5rDACARB40)
CVCL_RR57 (IMR-5rDOCE20)CVCL_RR58 (IMR-5rDOX20)CVCL_RR59 (IMR-5rETO100)
CVCL_RR60 (IMR-5rGEMCI20)CVCL_RS63 (IMR-5rIRINO1000)CVCL_RS62 (IMR-5rMEL1000)
CVCL_RR61 (IMR-5rMEL3000)CVCL_RR62 (IMR-5rOXALI4000)CVCL_RR63 (IMR-5rPCL20)
CVCL_RR64 (IMR-5rTOPO20)CVCL_RR37 (IMR-5rVCR10)CVCL_RS64 (IMR-5rVINB20)
CVCL_RR65 (IMR-5rVINOR20)
Sex of cell Male
Age at sampling 1Y1M
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; PubMed=31581737

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133823,24
D3S135816
D5S81811,12
D7S8209,10
D8S117913
D13S3179
D16S5398
D18S5112,15
D19S43314,15
D21S1130,31
FGA21,24
Penta D11,12
Penta E7,15
TH017,9.3
TPOX11
vWA15

Run an STR similarity search on this cell line
Publications

PubMed=6160155; DOI=10.1016/S0021-9258(19)70222-1
Momoi M., Kennett R.H., Glick M.C.
A membrane glycoprotein from human neuroblastoma cells isolated with the use of a monoclonal antibody.
J. Biol. Chem. 255:11914-11921(1980)

PubMed=12536080; DOI=10.1016/S0304-3835(02)00581-5
Fischer M., Berthold F.
Characterization of the gene expression profile of neuroblastoma cell line IMR-5 using serial analysis of gene expression.
Cancer Lett. 190:79-87(2003)

PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809
Schaefer K.-L., Brachwitz K., Wai D.H., Braun Y., Diallo R., Korsching E., Eisenacher M., Voss R., van Valen F., Baer C., Selle B., Spahn L., Liao S.-K., Lee K.A.W., Hogendoorn P.C.W., Reifenberger G., Gabbert H.E., Poremba C.
Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.
Cancer Res. 64:3395-3405(2004)

PubMed=16822308; DOI=10.1186/1471-2407-6-177
Dam V., Morgan B.T., Mazanek P., Hogarty M.D.
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177.1-177.10(2006)

PubMed=18724359; DOI=10.1038/nature07261
Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A., Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P., Laureys G., Speleman F., Kim C., Hou C.-P., Hakonarson H., Torkamani A., Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M., Maris J.M.
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=23202128; DOI=10.1038/ng.2493
Sausen M., Leary R.J., Jones S., Wu J., Reynolds C.P., Liu X.-Y., Blackford A.L., Parmigiani G., Diaz L.A. Jr., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=24466371; DOI=10.1593/tlo.13544
Loschmann N., Michaelis M., Rothweiler F., Zehner R., Cinatl J., Voges Y., Sharifi M., Riecken K., Meyer J., von Deimling A., Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28350380; DOI=10.1038/sdata.2017.33
Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L., Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033-170033(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31581737; DOI=10.3390/cells8101194
Povey J.F., Saintas E., Aderemi A.V., Rothweiler F., Zehner R., Dirks W.G., Cinatl J. Jr., Racher A.J., Wass M.N., Smales C.M., Michaelis M.
Intact-cell MALDI-ToF mass spectrometry for the authentication of drug-adapted cancer cell lines.
Cells 8:1194.1-1194.12(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ICLC; HTL00009
Cell line databases/resources CLO; CLO_0006950
CLDB; cl5097
cancercelllines; CVCL_1306
Cell_Model_Passport; SIDM01206
Cosmic-CLP; 907170
DepMap; ACH-002248
LINCS_LDP; LCL-1984
Anatomy/cell type resources BTO; BTO:0005846
Chemistry resources ChEMBL-Cells; CHEMBL3308201
ChEMBL-Targets; CHEMBL2366209
GDSC; 907170
PharmacoDB; IMR5_660_2019
PubChem_Cell_line; CVCL_1306
Encyclopedic resources Wikidata; Q54897648
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669935
GEO; GSM2371236
GEO; GSM2394389
Polymorphism and mutation databases Cosmic; 907170
Cosmic; 1019939
Cosmic; 1109364
Cosmic; 1161989
Cosmic; 1167417
Cosmic; 1890113
IARC_TP53; 21396
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number33