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Cellosaurus PFSK-1 (CVCL_1642)

Cell line name PFSK-1
Synonyms PFSk-1; PFSK1; PFSK
Accession CVCL_1642
Resource Identification Initiative To cite this cell line use: PFSK-1 (RRID:CVCL_1642)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ENCODE project common cell types; tier 3.
Population: Caucasian.
Doubling time: ~30 hours (ATCC=CRL-2060).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Brain, right frontal lobe; UBERON=UBERON_0002810.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys275Gly (c.823T>G); ClinVar=VCV001414106; Zygosity=Homozygous (Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.31
Native American0
East Asian, North2.03
East Asian, South0
South Asian0.77
European, North66.34
European, South30.55
Disease Primitive neuroectodermal tumor (NCIt: C3716)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 1Y10M
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; DepMap

Markers:
AmelogeninX,Y
CSF1PO11
D3S135815,16,18
D5S81811,12
D7S82010
D8S117913,14
D13S31712,14
D16S53913
D18S5112
D21S1128,32.2
FGA20,22
Penta D9,12
Penta E12,17
TH019,9.3
TPOX8,9
vWA17,18

Run an STR similarity search on this cell line
Web pages http://genome.ucsc.edu/ENCODE/protocols/cell/human/PFSK-1_protocol.pdf
Publications

PubMed=1316433; DOI=10.1097/00005072-199205000-00005
Fults D.W., Pedone C.A., Morse H.G., Rose J.W., McKay R.D.G.
Establishment and characterization of a human primitive neuroectodermal tumor cell line from the cerebral hemisphere.
J. Neuropathol. Exp. Neurol. 51:272-280(1992)

DOI=10.1016/B978-0-12-333530-2.50005-8
Nister M., Westermark B.
Human glioma cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York (1994)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=23325432; DOI=10.1101/gr.147942.112
Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-2060
IZSLER; BS TCL 202
Cell line databases/resources CLO; CLO_0008425
cancercelllines; CVCL_1642
Cell_Model_Passport; SIDM01132
Cosmic-CLP; 683667
DepMap; ACH-001711
LINCS_LDP; LCL-1407
Biological sample resources BioSample; SAMN03471425
ENCODE; ENCBS054ENC
Chemistry resources ChEMBL-Cells; CHEMBL3308802
ChEMBL-Targets; CHEMBL1075560
GDSC; 683667
PharmacoDB; PFSK1_1264_2019
PubChem_Cell_line; CVCL_1642
Encyclopedic resources Wikidata; Q54947302
Experimental variables resources EFO; EFO_0005234
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM923430
GEO; GSM1670349
Polymorphism and mutation databases Cosmic; 683667
Cosmic; 923655
Cosmic; 973260
Cosmic; 1728490
Cosmic; 1995615
IARC_TP53; 21279
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number34