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Cellosaurus VMRC-MELG (CVCL_1789)

[Text version]
Cell line name VMRC-MELG
Synonyms VMRCMELG; Leggee; Virginia Mason Research Center-Melanoma G
Accession CVCL_1789
Resource Identification Initiative To cite this cell line use: VMRC-MELG (RRID:CVCL_1789)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
From: Bean M.A.; Virginia Mason Research Center; Seattle; USA.
Population: Caucasian.
Doubling time: 60-80 hours (Note=Lot 06232008) (JCRB=JCRB0074).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.151-1G>A; ClinVar=VCV000635365; Zygosity=Homozygous; Note=Splice acceptor mutation (Cosmic-CLP; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African4.63
Native American0
East Asian, North0.15
East Asian, South2.24
South Asian0.66
European, North63.56
European, South28.76
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DepMap; JCRB

Markers:
AmelogeninX (Cosmic-CLP; DepMap)
X,Y (JCRB)
CSF1PO10
D3S135814,16
D5S81810,13
D7S8208,10
D8S117914
D13S3178,11
D16S53912
D18S5115,18
D21S1127,32.2
FGA19,23
Penta D10,12
Penta E5
TH016,7
TPOX9,11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB0074
Cell line databases/resources CLO; CLO_0037136
cancercelllines; CVCL_1789
Cell_Model_Passport; SIDM00319
Cosmic-CLP; 930301
DepMap; ACH-001704
LINCS_LDP; LCL-1258
Biological sample resources BioSample; SAMN03471062
Chemistry resources ChEMBL-Cells; CHEMBL3308809
ChEMBL-Targets; CHEMBL1075609
GDSC; 930301
PharmacoDB; VMRCMELG_1657_2019
PubChem_Cell_line; CVCL_1789
Encyclopedic resources Wikidata; Q54993286
Gene expression databases ArrayExpress; E-MTAB-783
Polymorphism and mutation databases Cosmic; 930301
IARC_TP53; 27587
Proteomic databases PRIDE; PXD030304
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number30