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Cellosaurus DSDh (CVCL_1918)

[Text version]
Cell line name DSDh
Accession CVCL_1918
Resource Identification Initiative To cite this cell line use: DSDh (RRID:CVCL_1918)
Comments Group: Retrovirus packaging cell line.
Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
Transfected with: UniProtKB; P03360; Avian reticuloendotheliosis virus gag-pol.
Transfected with: UniProtKB; P03399; Avian reticuloendotheliosis virus env.
Transfected with: MGI; MGI:94890; Dhfr (with p.Leu23Arg; methotrexate-resistant).
Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; VGNC; 42508; KRAS; Simple; p.Glu63Lys (c.187G>A); Zygosity=Heterozygous (from parent cell line).
Disease Canine osteosarcoma (NCIt: C120045)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Poodle.
Hierarchy Parent: CVCL_1916 (D-17)
Sex of cell Female
Age at sampling 11Y
Category Cancer cell line
Publications

PubMed=2304918; DOI=10.1073/pnas.87.4.1556
Hu W.-S., Temin H.M.
Genetic consequences of packaging two RNA genomes in one retroviral particle: pseudodiploidy and high rate of genetic recombination.
Proc. Natl. Acad. Sci. U.S.A. 87:1556-1560(1990)

Cross-references
Cell line collections (Providers) ATCC; CRL-2131
Cell line databases/resources CLO; CLO_0002828
Encyclopedic resources Wikidata; Q54831449
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number14