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Cellosaurus ESO-51 (CVCL_2036)

[Text version]
Cell line name ESO-51
Synonyms ESO51
Accession CVCL_2036
Resource Identification Initiative To cite this cell line use: ESO-51 (RRID:CVCL_2036)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Genome sequenced.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Esophagus, distal; UBERON=UBERON_0013473.
Sequence variations
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.22
Native American0.59
East Asian, North0
East Asian, South1.07
South Asian1.19
European, North50.02
European, South43.9
Disease Esophageal adenocarcinoma (NCIt: C4025)
Adenocarcinoma of the esophagus (ORDO: Orphanet_99976)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 74Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DepMap; DSMZ; ECACC; PubMed=20075370

Markers:
AmelogeninX (DSMZ; ECACC; PubMed=20075370)
X,Y (Cosmic-CLP)
CSF1PO10
D2S133825
D3S135815,16
D5S81811
D7S8208 (Cosmic-CLP; DepMap; DSMZ; PubMed=20075370)
8.2 (ECACC)
D8S117910 (DSMZ)
10,11,12 (DepMap; PubMed=20075370)
D13S31711
D16S53913
D18S5117,20
D19S43312
D21S1130,33.2 (DepMap; PubMed=20075370)
33.2 (DSMZ)
FGA21,22
Penta D9,13
Penta E17
TH019
TPOX8
vWA14,15

Run an STR similarity search on this cell line
Publications

PubMed=20075370; DOI=10.1093/jnci/djp499
Boonstra J.J., van Marion R., Beer D.G., Lin L., Chaves P., Ribeiro C., Pereira A.D., Roque L., Darnton S.J., Altorki N.K., Schrump D.S., Klimstra D.S., Tang L.H., Eshleman J.R., Alvarez H., Shimada Y., van Dekken H., Tilanus H.W., Dinjens W.N.M.
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
J. Natl. Cancer Inst. 102:271-274(2010)

PubMed=23795680; DOI=10.1111/dote.12095
Boonstra J.J., Tilanus H.W., Dinjens W.N.M.
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Dis. Esophagus 28:90-96(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27594985; DOI=10.12688/f1000research.7033.1
Contino G., Eldridge M.D., Secrier M., Bower L., Elliott R.F., Weaver J., Lynch A.G., Edwards P.A.W., Fitzgerald R.C.
Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.
F1000Research 5:1336.1-1336.12(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-694
ECACC; 11012010
Cell line databases/resources cancercelllines; CVCL_2036
Cell_Model_Passport; SIDM00538
Cosmic-CLP; 1503367
DepMap; ACH-001497
DSMZCellDive; ACC-694
Biological sample resources BioSample; SAMN03473444
CRISP screens repositories BioGRID_ORCS_Cell_line; 890
Chemistry resources GDSC; 1503367
PharmacoDB; ESO51_346_2019
Encyclopedic resources Wikidata; Q54832833
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669777
Polymorphism and mutation databases Cosmic; 1599338
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number31