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Cellosaurus LUDLU-1 (CVCL_2582)

[Text version]
Cell line name LUDLU-1
Synonyms Ludlu-1; LUDLU 1; LUDLU1
Accession CVCL_2582
Resource Identification Initiative To cite this cell line use: LUDLU-1 (RRID:CVCL_2582)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: TCGA-110-CL cell line panel.
Population: Caucasian.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Genome sequenced.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (Cosmic-CLP; DepMap).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,03:01
HLA-BB*15:01,18:01
HLA-CC*05:01,07:02
Class II
HLA-DQDQA1*01:02,02:01
HLA-DRDRB1*11:30,15:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.82
Native American0.66
East Asian, North3.82
East Asian, South0
South Asian0
European, North56.05
European, South37.65
Disease Lung squamous cell carcinoma (NCIt: C3493)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2296 ! AGLCL [Human 1989]
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
STR profile Source(s): ECACC; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11
D3S135816,18
D5S81812
D7S82010,12
D8S11798,15
D13S31712
D16S53913,14
D18S5118
D21S1128
FGA25
Penta D10
Penta E12,19
TH016
TPOX8,11
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=2577272; DOI=10.1002/gcc.2870010115
Rabbitts P.H., Douglas J., Daly M., Sundaresan V., Fox B., Haselton P., Wells F., Albertson D.G., Waters J., Bergh J.
Frequency and extent of allelic loss in the short arm of chromosome 3 in nonsmall-cell lung cancer.
Genes Chromosomes Cancer 1:95-105(1989)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23226101; DOI=10.1593/neo.121380
Stead L.F., Berri S., Wood H.M., Egan P., Conway C., Daly C., Papagiannopoulos K., Rabbitts P.H.
The transcriptional consequences of somatic amplifications, deletions, and rearrangements in a human lung squamous cell carcinoma.
Neoplasia 14:1075-1086(2012)

PubMed=24002593; DOI=10.1038/bjc.2013.452
Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.
Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.
Br. J. Cancer 109:1599-1608(2013)

PubMed=24244370; DOI=10.1371/journal.pone.0078823
Stead L.F., Egan P., Devery A.M., Conway C., Daly C., Berri S., Wood H.M., Belvedere O., Papagiannopoulos K., Ryan A., Rabbitts P.H.
An integrated inspection of the somatic mutations in a lung squamous cell carcinoma using next-generation sequencing.
PLoS ONE 8:E78823-E78823(2013)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2
Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574.1-3574.11(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

Cross-references
Cell line collections (Providers) ECACC; 92012463
Cell line databases/resources CLO; CLO_0007417
CLDB; cl3269
cancercelllines; CVCL_2582
Cell_Model_Passport; SIDM01363
DepMap; ACH-000390
LINCS_LDP; LCL-1589
Biological sample resources BioSample; SAMN03473041
BioSample; SAMN10987864
CRISP screens repositories BioGRID_ORCS_Cell_line; 561
Chemistry resources PharmacoDB; LUDLU1_871_2019
Encyclopedic resources Wikidata; Q54903257
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM827451
GEO; GSM887284
GEO; GSM888359
GEO; GSM1374639
Polymorphism and mutation databases Cosmic; 753591
Cosmic; 2060536
IARC_TP53; 21483
LiGeA; CCLE_553
Progenetix; CVCL_2582
Sequence databases EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number32