Cellosaurus cell line ONE58 (CVCL_2671)

• Mutation; HGNC; 3373; EP300; Simple; p.Gln1993Ter (c.5797C>T); Zygosity=Heterozygous (DepMap).
  
• Mutation; HGNC; 11998; TP53; Simple; p.Tyr205Cys (c.614A>G); ClinVar=VCV000376681; Zygosity=Homozygous (DepMap).
  

PubMed=1703129; DOI=10.1002/ijc.2910470219
Manning L.S., Whitaker D., Murch A.R., Garlepp M.J., Davis M.R., Musk A.W., Robinson B.W.S.
Establishment and characterization of five human malignant mesothelioma cell lines derived from pleural effusions.
Int. J. Cancer 47:285-290(1991)

PubMed=21642991; DOI=10.1038/ng.855
Bott M.J., Brevet M., Taylor B.S., Shimizu S., Ito T., Wang L., Creaney J., Lake R.A., Zakowski M.F., Reva B., Sander C., Delsite R., Powell S.N., Zhou Q., Shen R.-L., Olshen A.B., Rusch V.W., Ladanyi M.
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.
Nat. Genet. 43:668-672(2011)

PubMed=25902174; DOI=10.1097/JTO.0000000000000493
Miyanaga A., Masuda M., Tsuta K., Kawasaki K., Nakamura Y., Sakuma T., Asamura H., Gemma A., Yamada T.
Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.
J. Thorac. Oncol. 10:844-851(2015)

PubMed=28387650; DOI=10.21873/cgp.20023
Creaney J., Dick I.M., Leon J.S., Robinson B.W.S.
A proteomic analysis of the malignant mesothelioma secretome using iTRAQ.
Cancer Genomics Proteomics 14:103-117(2017)