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Cellosaurus I 9.2 (CVCL_3725)

[Text version]
Cell line name I 9.2
Synonyms I9.2; I9-2; I-9-2
Accession CVCL_3725
Resource Identification Initiative To cite this cell line use: I 9.2 (RRID:CVCL_3725)
Comments Population: Caucasian.
Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Omics: DNA methylation analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1061 (Jurkat clone A3)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO11,12
D5S8189
D7S8208,9.2
D13S3178,11
D16S53911
TH016,9.3
TPOX8,10
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=10616904
Juo P., Woo M.S.-A., Kuo C.J., Signorelli P., Biemann H.-P., Hannun Y.A., Blenis J.
FADD is required for multiple signaling events downstream of the receptor Fas.
Cell Growth Differ. 10:797-804(1999)

Cross-references
Cell line collections (Providers) ATCC; CRL-2571
Cell line databases/resources CLO; CLO_0004317
cancercelllines; CVCL_3725
Cell_Model_Passport; SIDM01224
LINCS_LDP; LCL-1028
Anatomy/cell type resources BTO; BTO:0003683
Biological sample resources BioSample; SAMN03471679
Chemistry resources PharmacoDB; I92_649_2019
Encyclopedic resources Wikidata; Q54897066
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GM1669925
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number24