Cellosaurus logo
expasy logo

Cellosaurus IIICF/c (CVCL_4415)

[Text version]
Cell line name IIICF/c
Synonyms III-CF/c; III-CF culture C
Accession CVCL_4415
Resource Identification Initiative To cite this cell line use: IIICF/c (RRID:CVCL_4415)
Comments Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
Caution: Was briefly displayed in Cell Bank Australia under catalog number CBA-0039 but was never intended to be distributed.
Derived from site: In situ; Breast, stroma; UBERON=UBERON_0003584.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Thr125Thr (c.375G>A); ClinVar=VCV000177825; Zygosity=Hemizygous; Note=Impairs TP53 splicing dramatically (from parent cell line).
Disease Li-Fraumeni syndrome (NCIt: C3476)
Li-Fraumeni syndrome (ORDO: Orphanet_524)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_ZT89 (IIICF)
Children:
CVCL_4411 (IIICF-E6E7/C4)CVCL_4412 (IIICF-T/A6)CVCL_6F12 (IIICF-T/B1)
CVCL_4413 (IIICF-T/B3)CVCL_6F13 (IIICF-T/C3)CVCL_4416 (IIICF/c/rasT21)
Sex of cell Female
Age at sampling 30-40Y
Category Spontaneously immortalized cell line
Publications

PubMed=7651392; DOI=10.1128/mcb.15.9.4745
Rogan E.M., Bryan T.M., Hukku B., MacLean K., Chang A.C.-M., Moy E.L., Englezou A., Warneford S.G., Dalla-Pozza L., Reddel R.R.
Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts.
Mol. Cell. Biol. 15:4745-4753(1995)

PubMed=9175740; DOI=10.1093/hmg/6.6.921
Bryan T.M., Marusic L., Bacchetti S., Namba M., Reddel R.R.
The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit.
Hum. Mol. Genet. 6:921-926(1997)

CLPUB00712
Henson J.D.
The role of alternative lengthening of telomeres in human cancer.
Thesis PhD (2006), University of Sydney, Australia

PubMed=19468068; DOI=10.1083/jcb.200810084
Jiang W.-Q., Zhong Z.-H., Nguyen A., Henson J.D., Toouli C.D., Braithwaite A.W., Reddel R.R.
Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins.
J. Cell Biol. 185:797-810(2009)

PubMed=19935656; DOI=10.1038/nbt.1587
Henson J.D., Cao Y., Huschtscha L.I., Chang A.C.-M., Au A.Y.M., Pickett H.A., Reddel R.R.
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)

PubMed=22829774; DOI=10.1371/journal.pgen.1002772
Lovejoy C.A., Li W.-D., Reisenweber S., Thongthip S., Bruno J., de Lange T., De S., Petrini J.H.J., Sung P.A., Jasin M., Rosenbluh J., Zwang Y., Weir B.A., Hatton C., Ivanova E.V., MacConaill L.E., Hanna M., Hahn W.C., Lue N.F., Reddel R.R., Jiao Y.-C., Kinzler K.W., Vogelstein B., Papadopoulos N., Meeker A.K.
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
PLoS Genet. 8:E1002772-E1002772(2012)

Cross-references
Encyclopedic resources Wikidata; Q54897435
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number14