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Cellosaurus IB3-1/C38 (CVCL_4462)

Cell line name IB3-1/C38
Synonyms C38
Accession CVCL_4462
Resource Identification Initiative To cite this cell line use: IB3-1/C38 (RRID:CVCL_4462)
Comments Transfected with: HGNC; 1884; CFTR.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: Ad12-SV40.
Disease Cystic fibrosis (NCIt: C2975)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0338 (IB3-1)
Sex of cell Male
Category Transformed cell line
STR profile Source(s): ATCC


PubMed=1380129; DOI=10.1038/358581a0
Egan M., Flotte T.R., Afione S.A., Solow R., Zeitlin P.L., Carter B.J., Guggino W.B.
Defective regulation of outwardly rectifying Cl- channels by protein kinase A corrected by insertion of CFTR.
Nature 358:581-584(1992)

Flotte T.R., Afione S.A., Solow R., Drumm M.L., Markakis D., Guggino W.B., Zeitlin P.L., Carter B.J.
Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter.
J. Biol. Chem. 268:3781-3790(1993)

PubMed=18441018; DOI=10.1194/jlr.M700388-JLR200
Andersson C., Al-Turkmani M.R., Savaille J.E., Alturkmani R., Katrangi W., Cluette-Brown J.E., Zaman M.M., Laposata M., Freedman S.D.
Cell culture models demonstrate that CFTR dysfunction leads to defective fatty acid composition and metabolism.
J. Lipid Res. 49:1692-1700(2008)

Cell line collections ATCC; CRL-2779 - Discontinued
ATCC; JHU-54 - Discontinued
Ontologies BTO; BTO:0004447
CLO; CLO_0002118
Biological sample resources BioSample; SAMN03471787