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Cellosaurus MDA-PCa-2b (CVCL_4748)

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Cell line name MDA-PCa-2b
Synonyms MDA PCa 2b; MDAPCa-2b; MDAPCa2b; MDAPCA2B; MDAPC2B; MDA2B; M.D. Anderson-Prostate Cancer-2b
Accession CVCL_4748
Resource Identification Initiative To cite this cell line use: MDA-PCa-2b (RRID:CVCL_4748)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: TCGA-110-CL cell line panel.
Population: African American.
Doubling time: 42-53 hours (Note=In BRFF-HPC1 + 20% FBS), 61-73 hours (Note=In F12K(+) + 20% FBS) (PubMed=9815652); 89.15 hours (GrayJW panel).
Microsatellite instability: Instable (MSI) (PubMed=23671654; PubMed=31068700;).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Genome ancestry Source: PubMed=30894373

Origin% genome
African90.02
Native American0
East Asian, North2.64
East Asian, South0
South Asian0
European, North0
European, South7.34
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4867 (MDA-PCa-2b-hr)
Originate from same individual CVCL_4747 ! MDA-PCa-2a
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): ATCC; PubMed=14518029

Markers:
AmelogeninX,Y
CSF1PO10,12
D3S135814,17
D5S81812,13
D7S8208,10
D8S117914,15
D13S31711,12
D16S53910,11
D18S5116,17
D21S1133.2
FGA20,22
TH018,9
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=9815652
Navone N.M., Olive M., Ozen M., Davis R., Troncoso P., Tu S.-M., Johnston D., Pollack A., Pathak S., von Eschenbach A.C., Logothetis C.J.
Establishment of two human prostate cancer cell lines derived from a single bone metastasis.
Clin. Cancer Res. 3:2493-2500(1997)

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Russell P.J., Kingsley E.A.
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

PubMed=14518029; DOI=10.1002/pros.10290
van Bokhoven A., Varella-Garcia M., Korch C.T., Johannes W.U., Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S.
Molecular characterization of human prostate carcinoma cell lines.
Prostate 57:205-225(2003)

PubMed=14518030; DOI=10.1002/pros.10291
van Bokhoven A., Caires A., Di Maria M., Schulte A.P., Lucia M.S., Nordeen S.K., Miller G.J., Varella-Garcia M.
Spectral karyotype (SKY) analysis of human prostate carcinoma cell lines.
Prostate 57:226-244(2003)

CLPUB00698
van Bokhoven A.
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004), Katholieke Universiteit Nijmegen, Netherlands

PubMed=15486987; DOI=10.1002/pros.20158
Zhao H.-J., Kim Y., Wang P., Lapointe J., Tibshirani R., Pollack J.R., Brooks J.D.
Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines.
Prostate 63:187-197(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23671654; DOI=10.1371/journal.pone.0063056
Lu Y.-H., Soong T.D., Elemento O.
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:E63056-E63056(2013)

PubMed=30787054; DOI=10.1158/1055-9965.EPI-18-1132
Hooker S.E. Jr., Woods-Burnham L., Bathina M., Lloyd S., Gorjala P., Mitra R., Nonn L., Kimbro K.S., Kittles R.A.
Genetic ancestry analysis reveals misclassification of commonly used cancer cell lines.
Cancer Epidemiol. Biomarkers Prev. 28:1003-1009(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2
Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574.1-3574.11(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-2422
Cell line databases/resources CLO; CLO_0007629
cancercelllines; CVCL_4748
Cell_Model_Passport; SIDM01664
DepMap; ACH-000952
Anatomy/cell type resources BTO; BTO:0005050
Biological sample resources BioSample; SAMN03471841
BioSample; SAMN10988222
Chemistry resources PharmacoDB; MDAPCa2b_896_2019
Encyclopedic resources Wikidata; Q54904655
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM91928
GEO; GSM648821
GEO; GSM887302
GEO; GSM888377
Polymorphism and mutation databases Cosmic; 1689712
Cosmic; 2651771
Cosmic; 2669171
IARC_TP53; 30117
LiGeA; CCLE_281
Progenetix; CVCL_4748
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number32