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Cellosaurus MCF-7/4-HC (CVCL_4V53)

[Text version]
Cell line name MCF-7/4-HC
Synonyms MCF-7/4-hc; MCF7/4HC; MCF-7/OAP
Accession CVCL_4V53
Resource Identification Initiative To cite this cell line use: MCF-7/4-HC (RRID:CVCL_4V53)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:196991; 4-hydroperoxycyclophosphamide.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=3180059
Frei E. III, Teicher B.A., Holden S.A., Cathcart K.N.S., Wang Y.-Y.
Preclinical studies and clinical correlation of the effect of alkylating dose.
Cancer Res. 48:6417-6423(1988)

PubMed=8328987; DOI=10.1016/0006-2952(93)90231-K
Sreerama L., Sladek N.E.
Identification and characterization of a novel class 3 aldehyde dehydrogenase overexpressed in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance.
Biochem. Pharmacol. 45:2487-2505(1993)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4V53
Encyclopedic resources Wikidata; Q54904348
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number13