Cell line name |
MCF-7/AdrVp |
Synonyms |
MCF7/AdrVp; MCF-7-ADRVP; MCF-7 AdVp; MCF-7/AdrVp(100) |
Accession |
CVCL_4Y46 |
Resource Identification Initiative |
To cite this cell line use: MCF-7/AdrVp (RRID:CVCL_4Y46) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin). Selected for resistance to: ChEBI; CHEBI:9948; Verapamil (VPL). Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Invasive breast carcinoma of no special type (NCIt: C4194) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0031 (MCF-7) Children:
|
Sex of cell |
Female |
Age at sampling |
69Y |
Category |
Cancer cell line |
Publications | PubMed=1972154; DOI=10.1016/S0021-9258(19)38781-2 Chen Y.-N., Mickley L.A., Schwartz A.M., Acton E.M., Hwang J.-L., Fojo A.T. Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein. J. Biol. Chem. 265:10073-10080(1990) PubMed=7819048; DOI=10.1038/bjc.1995.11 Doyle L.A., Ross D.D., Sridhara R., Fojo A.T., Kaufmann S.H., Lee E.J., Schiffer C.A. Expression of a 95 kDa membrane protein is associated with low daunorubicin accumulation in leukaemic blast cells. Br. J. Cancer 71:52-58(1995) PubMed=9865745 Rabindran S.K., He H.-Y., Singh M., Brown E., Collins K.I., Annable T., Greenberger L.M. Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C. Cancer Res. 58:5850-5858(1998) PubMed=14576842; DOI=10.1038/sj.onc.1206938 Doyle L.A., Ross D.D. Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2). Oncogene 22:7340-7358(2003) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_4Y46
|
Encyclopedic resources |
Wikidata; Q54904351
|
Entry history |
Entry creation | 14-Dec-2015 |
Last entry update | 05-Oct-2023 |
Version number | 13 |
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