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Cellosaurus SNU-1033 (CVCL_5002)

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Cell line name SNU-1033
Synonyms SNU1033
Accession CVCL_5002
Resource Identification Initiative To cite this cell line use: SNU-1033 (RRID:CVCL_5002)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Seoul National University (SNU) cell line collection.
Population: Korean.
Doubling time: 42 hours (PubMed=10362137).
Microsatellite instability: Stable (MSS) (PubMed=10674020; PubMed=25926053).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Rectum; UBERON=UBERON_0001052.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=10362137; DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro190Leu (c.569C>T); ClinVar=VCV000418517; Zygosity=Homozygous (PubMed=10362137; DepMap).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*24:02,24:02
HLA-BB*40:01,51:01
HLA-CC*15:02,15:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African18.67
Native American0
East Asian, North56.8
East Asian, South0
South Asian0
European, North0
European, South24.53
Disease Rectal adenocarcinoma (NCIt: C9383)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 45Y
Category Cancer cell line
STR profile Source(s): Genomics_Center_BCF_Technion; KCLB; PubMed=25926053

Markers:
AmelogeninX
CSF1PO10
D1S165613
D2S44110,12
D2S133818,26
D3S135814,17 (KCLB)
17 (Genomics_Center_BCF_Technion)
D5S81813
D7S82011,12 (Genomics_Center_BCF_Technion; PubMed=25926053)
12 (KCLB)
D8S117912,13
D10S124813,15
D12S39118,21
D13S31710
D16S5399
D18S5113
D19S43313,14
D21S1129,30
D22S104517
FGA23
Penta D11,12
Penta E11
TH019
TPOX11
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=10362137; DOI=10.1002/(SICI)1097-0215(19990611)81:6<902::AID-IJC11>3.0.CO;2-T
Oh J.H., Ku J.-L., Yoon K.-A., Kwon H.-J., Kim W.-H., Park H.-S., Yeo K.-S., Song S.-Y., Chung J.-K., Park J.-G.
Establishment and characterization of 12 human colorectal-carcinoma cell lines.
Int. J. Cancer 81:902-910(1999)

PubMed=10674020; DOI=10.1016/S0959-8049(99)00206-3
Ku J.-L., Yoon K.-A., Kim D.-Y., Park J.-G.
Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines.
Eur. J. Cancer 35:1724-1729(1999)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1
Ku J.-L., Park J.-G.
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) KCLB; 01033
Cell line databases/resources cancercelllines; CVCL_5002
Cell_Model_Passport; SIDM00192
ColonAtlas; SNU1033
DepMap; ACH-000286
Biological sample resources BioSample; SAMN10987752
Chemistry resources PharmacoDB; SNU1033_1433_2019
Encyclopedic resources Wikidata; Q54955088
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM1448078
Polymorphism and mutation databases Cosmic; 738855
Cosmic; 2612379
Cosmic; 2651858
IARC_TP53; 10837
LiGeA; CCLE_623
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number27