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Cellosaurus SNU-1076 (CVCL_5006)

Cell line name SNU-1076
Synonyms SNU1076; NCI-SNU-1076
Accession CVCL_5006
Resource Identification Initiative To cite this cell line use: SNU-1076 (RRID:CVCL_5006)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Seoul National University (SNU) cell line collection.
Population: Korean.
Doubling time: 36 hours (PubMed=10369293).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
Sequence variations
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Pro114His (c.341C>A) (p.Ala128Ala, c.384C>A); ClinVar=VCV000376383; Zygosity=Unspecified (PubMed=10369293).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (DepMap).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,02:01
HLA-BB*13:01,13:01
HLA-CC*03:04,06:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.88
Native American0
East Asian, North66.81
East Asian, South28.32
South Asian0
European, North0
European, South1.99
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 60Y
Category Cancer cell line
STR profile Source(s): Genomics_Center_BCF_Technion; KCLB

Markers:
AmelogeninX,Y
CSF1PO11,12
D1S165615
D2S44111
D2S133819,24
D3S135815
D5S8189,12
D7S82011,12
D8S117910,15
D10S124813
D12S39119,20
D13S3178,10
D16S53913
D18S5114
D19S43315.2
D21S1130
D22S104515,17
DYS39111
FGA24,25
Penta D9,10
Penta E12,22
TH016 (Genomics_Center_BCF_Technion)
6,7 (KCLB)
TPOX8,11
vWA15,16 (KCLB)
16 (Genomics_Center_BCF_Technion)

Run an STR similarity search on this cell line
Publications

PubMed=10369293; DOI=10.1097/00005537-199906000-00025
Ku J.-L., Kim W.-H., Lee J.-H., Park H.-S., Kim K.H., Sung M.-W., Park J.-G.
Establishment and characterization of human laryngeal squamous cell carcinoma cell lines.
Laryngoscope 109:976-982(1999)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1
Ku J.-L., Park J.-G.
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) KCLB; 01076
Cell line databases/resources cancercelllines; CVCL_5006
Cell_Model_Passport; SIDM00168
DepMap; ACH-000549
Anatomy/cell type resources BTO; BTO:0005922
Biological sample resources BioSample; SAMN10988066
Chemistry resources PharmacoDB; SNU1076_1437_2019
Encyclopedic resources Wikidata; Q54955093
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887603
GEO; GSM888686
Polymorphism and mutation databases Cosmic; 934177
IARC_TP53; 30157
LiGeA; CCLE_803
Progenetix; CVCL_5006
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number27