Cellosaurus cell line H-MESO-1 (CVCL_5759)

• Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=21642991).
  

PubMed=3496960
Griffin T.W., Richardson C., Houston L.L., LePage D., Bogden A., Raso V.
Antitumor activity of intraperitoneal immunotoxins in a nude mouse model of human malignant mesothelioma.
Cancer Res. 47:4266-4270(1987)

PubMed=3555770
Reale F.R., Griffin T.W., Compton J.M., Graham S., Townes P.L., Bogden A.
Characterization of a human malignant mesothelioma cell line (H-MESO-1): a biphasic solid and ascitic tumor model.
Cancer Res. 47:3199-3205(1987)

PubMed=10373640; DOI=10.3892/ijmm.4.1.67
Scarpa S., Giuffrida A., Fazi M., Coletti A., Palumbo C., Pass H.I., Procopio A., Modesti A.
Migration of mesothelioma cells correlates with histotype-specific synthesis of extracellular matrix.
Int. J. Mol. Med. 4:67-71(1999)

PubMed=21454801; DOI=10.1165/rcmb.2010-0282OC
Shukla A., Barrett T.F., MacPherson M.B., Hillegass J.M., Fukagawa N.K., Swain W.A., O'Byrne K.J., Testa J.R., Pass H.I., Faux S.P., Mossman B.T.
An extracellular signal-regulated kinase 2 survival pathway mediates resistance of human mesothelioma cells to asbestos-induced injury.
Am. J. Respir. Cell Mol. Biol. 45:906-914(2011)

PubMed=21642991; DOI=10.1038/ng.855
Bott M.J., Brevet M., Taylor B.S., Shimizu S., Ito T., Wang L., Creaney J., Lake R.A., Zakowski M.F., Reva B., Sander C., Delsite R., Powell S.N., Zhou Q., Shen R.-L., Olshen A.B., Rusch V.W., Ladanyi M.
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.
Nat. Genet. 43:668-672(2011)

PubMed=28159921; DOI=10.18632/oncotarget.14907
Masuelli L., Benvenuto M., Di Stefano E., Mattera R., Fantini M., De Feudis G., De Smaele E., Tresoldi I., Giganti M.G., Modesti A., Bei R.
Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line.
Oncotarget 8:34405-34422(2017)