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Cellosaurus Walvax-2 (CVCL_5J50)

[Text version]
Cell line name Walvax-2
Synonyms WALVAX-2; WALVAX 2; Walvax 2; WALVAX2; Walvax2
Accession CVCL_5J50
Resource Identification Initiative To cite this cell line use: Walvax-2 (RRID:CVCL_5J50)
Comments Group: Patented cell line.
Group: Vaccine production cell line.
Registration: International Depositary Authority, China Center for Type Culture Collection; CCTCC C201055.
Senescence: Maintains excellent capabilities for growth and proliferation until PDL 50 (maximum PDL is 58).
Doubling time: 39-41 hours (Note=At 28th passage), 40-42 hours (Note=At 38th passage), 57-62 hours (Note=At 48th passage) (PubMed=25803132).
Anecdotal: Is causing an outrage in some pro-lifer circles because it is a cell line originating from an aborted (for medical reasons) 3-month old female fetus.
Derived from site: In situ; Fetal lung; UBERON=UBERON_0005597.
Cell type: Fibroblast of lung; CL=CL_0002553.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 3FM
Category Finite cell line
STR profile Source(s): PubMed=25803132; PubMed=26116706

Markers:
AmelogeninX
CSF1PO10,12
D2S133820,25
D3S135815,16
D5S81810,11
D6S104314,19
D7S8208,12
D8S117913,15
D12S39119,22
D13S31711,12
D16S5399,12
D18S5115,18
D19S43313.2,14.2
D21S1129,30
FGA21,24
Penta D10,11
Penta E5,18
TH016,9
TPOX8,11
vWA18

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Publications

Patent=CN102911910A
Huang Z., He L.-F., Zhang W., Ma B., Wang L.-L., Zhao Q.-Y., Zhang Y., Wu W.-J., Chen M., Wang X., Tang Y.-F.
Human embryo lung fibroblast strain and method for using human embryo lung fibroblast strain for producing hand-foot-mouth viral vaccine.
Patent number CN102911910A, 06-Feb-2013

Patent=CN103525770B
Ma B., Yang Z., He L.-F., Wang L.-L., Chen M., Wang X.
Application of human fetal lung fibroblast line in preparation of hepatitis A vaccines.
Patent number CN103525770B, 19-Aug-2015

PubMed=25803132; DOI=10.1080/21645515.2015.1009811
Ma B., He L.-F., Zhang Y.-L., Chen M., Wang L.-L., Yang H.-W., Yan T., Sun M.-X., Zheng C.-Y.
Characteristics and viral propagation properties of a new human diploid cell line, Walvax-2, and its suitability as a candidate cell substrate for vaccine production.
Hum. Vaccin. Immunother. 11:998-1009(2015)

PubMed=26116706; DOI=10.1096/fj.14-266718
Ye F., Chen C.-G., Qin J., Liu J., Zheng C.-Y.
Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.
FASEB J. 29:4268-4272(2015)

Cross-references
Cell line databases/resources CCRID; 4201PAT-CCTCC00374
Encyclopedic resources Wikidata; Q54993580
Entry history
Entry creation14-Dec-2015
Last entry update29-Jun-2023
Version number18