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Cellosaurus GIST522 (CVCL_7042)

[Text version]
Cell line name GIST522
Synonyms GIST-522
Accession CVCL_7042
Resource Identification Initiative To cite this cell line use: GIST522 (RRID:CVCL_7042)
Comments Cell type: Interstitial cell of Cajal; CL=CL_0002088.
Sequence variations
  • Mutation; HGNC; 6342; KIT; Simple; p.Glu554_Lys558del (c.1661_1675del); Zygosity=Heterozygous (PubMed=19706776).
Disease Gastrointestinal stromal tumor (NCIt: C3868)
Gastrointestinal stromal tumor (ORDO: Orphanet_44890)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Cancer cell line
Publications

PubMed=19706776; DOI=10.1158/0008-5472.CAN-08-4004
Muhlenberg T., Zhang Y.-X., Wagner A.J., Grabellus F., Bradner J., Taeger G., Lang H., Taguchi T., Schuler M., Fletcher J.A., Bauer S.
Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.
Cancer Res. 69:6941-6950(2009)

PubMed=30488756; DOI=10.1080/15384101.2018.1553335
Tu Y.-Q., Zuo R., Ni N., Eilers G., Wu D.-L., Pei Y.-T., Nie Z.-M., Wu Y.-Q., Wu Y.-H., Ou W.-B.
Activated tyrosine kinases in gastrointestinal stromal tumor with loss of KIT oncoprotein expression.
Cell Cycle 17:2577-2592(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7042
Encyclopedic resources Wikidata; Q54835860
Gene expression databases GEO; GSM486231
Polymorphism and mutation databases Cosmic; 1180676
Progenetix; CVCL_7042
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number14