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Cellosaurus GM847/ATRkd (CVCL_7947)

[Text version]
Cell line name GM847/ATRkd
Synonyms GM847 ATR kinase dead; ATRkd
Accession CVCL_7947
Resource Identification Initiative To cite this cell line use: GM847/ATRkd (RRID:CVCL_7947)
Comments Population: African American.
Transfected with: HGNC; 882; ATR (with p.Asp2494Glu = ATRkd).
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Lesch-Nyhan syndrome (NCIt: C61255)
Lesch-Nyhan syndrome (ORDO: Orphanet_510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7908 (GM00847)
Sex of cell Male
Age at sampling 5Y6M
Category Transformed cell line
Publications

PubMed=9427750; DOI=10.1093/emboj/17.1.159
Cliby W.A., Roberts C.J., Cimprich K.A., Stringer C.M., Lamb J.R., Schreiber S.L., Friend S.H.
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.
EMBO J. 17:159-169(1998)

Cross-references
Encyclopedic resources Wikidata; Q54751292
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number15