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Cellosaurus MCF-7/LY2 (CVCL_9579)

[Text version]
Cell line name MCF-7/LY2
Synonyms LY2; LY-2
Accession CVCL_9579
Resource Identification Initiative To cite this cell line use: MCF-7/LY2 (RRID:CVCL_9579)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: GrayJW breast cancer cell line panel.
Population: Caucasian.
Doubling time: 56.10 hours (GrayJW panel).
Selected for resistance to: ChEBI; CHEBI:90187; Lilly 117018 (LY 117018).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*02:01,02:01
HLA-BB*44:02,18:01
HLA-CC*05:01,05:01
Class II
HLA-DQDQA1*01:02,01:02
DQB1*06:02,06:02
HLA-DRDRB1*15:01,15:01
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Web pages https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Publications

PubMed=4029083; DOI=10.1210/endo-117-4-1409
Bronzert D.A., Greene G.L., Lippman M.E.
Selection and characterization of a breast cancer cell line resistant to the antiestrogen LY 117018.
Endocrinology 117:1409-1417(1985)

PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008
Neve R.M., Chin K., Fridlyand J., Yeh J., Baehner F.L., Fevr T., Clark L., Bayani N., Coppe J.-P., Tong F., Speed T., Spellman P.T., DeVries S., Lapuk A., Wang N.J., Kuo W.-L., Stilwell J.L., Pinkel D., Albertson D.G., Waldman F.M., McCormick F., Dickson R.B., Johnson M.D., Lippman M.E., Ethier S.P., Gazdar A.F., Gray J.W.
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Cancer Cell 10:515-527(2006)

PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020
Timmerman L.A., Holton T., Yuneva M., Louie R.J., Padro M., Daemen A., Hu M., Chan D.A., Ethier S.P., van 't Veer L.J., Polyak K., McCormick F., Gray J.W.
Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.
Cancer Cell 24:450-465(2013)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C.B., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y.-L., Mills G.B., Cho R.J., Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

Cross-references
Cell line databases/resources CLO; CLO_0009913
cancercelllines; CVCL_9579
DepMap; ACH-002325
LINCS_HMS; 51095
LINCS_LDP; LCL-2076
Chemistry resources PharmacoDB; LY2_874_2019
Encyclopedic resources Wikidata; Q54904374
Experimental variables resources EFO; EFO_0001199
Gene expression databases ArrayExpress; E-TABM-157
GEO; GSM1053705
GEO; GSM1172972
GEO; GSM1172879
Polymorphism and mutation databases Cosmic; 1136350
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number27