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Cellosaurus CTX0E03 (CVCL_9T00)

[Text version]
Cell line name CTX0E03
Synonyms CTXOE03; CTX-OE-03; CTX-OE03
Accession CVCL_9T00
Resource Identification Initiative To cite this cell line use: CTX0E03 (RRID:CVCL_9T00)
Comments Group: Patented cell line.
From: ReNeuron, Ltd; Pencoed; United Kingdom.
Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 04091601.
Doubling time: 3-4 days (Patent=US7666672).
Transfected with: HGNC; 7553; MYC.
Transformant: Myc.
Derived from site: In situ; Fetal brain, cerebral cortex; UBERON=UBERON_0006237+UBERON_0000956.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 12FW
Category Conditionally immortalized cell line
Web pages https://discovery.lifemapsc.com/stem-cell-differentiation/in-vitro-cells/brain-homo-sapiens-neural-stem-cell-line-ctx0e03-reneuron
Publications

PubMed=16464451; DOI=10.1016/j.expneurol.2005.12.011
Pollock K., Stroemer P., Patel S., Stevanato L., Hope A., Miljan E.A., Dong Z.-P., Hodges H., Price J., Sinden J.D.
A conditionally immortal clonal stem cell line from human cortical neuroepithelium for the treatment of ischemic stroke.
Exp. Neurol. 199:143-155(2006)

PubMed=19343502; DOI=10.1007/s10529-009-9989-1
Thomas R.J., Hope A.D., Hourd P., Baradez M., Miljan E.A., Sinden J.D., Williams D.J.
Automated, serum-free production of CTX0E03: a therapeutic clinical grade human neural stem cell line.
Biotechnol. Lett. 31:1167-1172(2009)

PubMed=19633272; DOI=10.1177/1545968309335978
Stroemer P., Patel S., Hope A., Oliveira C., Pollock K., Sinden J.D.
The neural stem cell line CTX0E03 promotes behavioral recovery and endogenous neurogenesis after experimental stroke in a dose-dependent fashion.
Neurorehabil. Neural Repair 23:895-909(2009)

Patent=US7666672
Sinden J.D., Pollock K., Stroemer P.
Cell lines.
Patent number US7666672, 23-Feb-2010

PubMed=32374064; DOI=10.1002/stem.3191
Yoon Y., Kim H.S., Jeon I., Noh J.-E., Park H.J., Lee S., Park I.-H., Stevanato L., Hicks C., Corteling R., Barker R.A., Sinden J.D., Song J.
Implantation of the clinical-grade human neural stem cell line, CTX0E03, rescues the behavioral and pathological deficits in the quinolinic acid-lesioned rodent model of Huntington's disease.
Stem Cells 38:936-947(2020)

Cross-references
Encyclopedic resources Wikidata; Q54814777
Entry history
Entry creation23-Feb-2016
Last entry update29-Jun-2023
Version number13