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Cellosaurus VMM5A (CVCL_A740)

[Text version]
Cell line name VMM5A
Synonyms VMM-5A; VMM5
Accession CVCL_A740
Resource Identification Initiative To cite this cell line use: VMM5A (RRID:CVCL_A740)
Comments Population: Caucasian.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=26405815).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Arg173His (c.518G>A); ClinVar=VCV000376032; Zygosity=Unspecified (ATCC=CRL-3226).
HLA typing Source: PubMed=10752474
Class I
HLA-AA*02:01
HLA-BB*39
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_S584 ! VMM5B
Sex of cell Male
Age at sampling 81Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX,Y
CSF1PO11
D5S8189
D7S8209,10
D13S31712
D16S53912
TH019.3
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=7681084; DOI=10.4049/jimmunol.150.7.2955
Slingluff C.L. Jr., Cox A.L., Henderson R.A., Hunt D.F., Engelhard V.H.
Recognition of human melanoma cells by HLA-A2.1-restricted cytotoxic T lymphocytes is mediated by at least six shared peptide epitopes.
J. Immunol. 150:2955-2963(1993)

PubMed=10752474; DOI=10.1007/s002620050015
Slingluff C.L. Jr., Colella T.A., Thompson L., Graham D.D., Skipper J.C.A., Caldwell J., Brinckerhoff L., Kittlesen D.J., Deacon D.H., Oei C., Harthun N.L., Huczko E.L., Hunt D.F., Darrow T.L., Engelhard V.H.
Melanomas with concordant loss of multiple melanocytic differentiation proteins: immune escape that may be overcome by targeting unique or undefined antigens.
Cancer Immunol. Immunother. 48:661-672(2000)

PubMed=14871852; DOI=10.1158/0008-5472.CAN-03-2209
Hogan K.T., Coppola M.A., Gatlin C.L., Thompson L.W., Shabanowitz J., Hunt D.F., Engelhard V.H., Ross M.M., Slingluff C.L. Jr.
Identification of novel and widely expressed cancer/testis gene isoforms that elicit spontaneous cytotoxic T-lymphocyte reactivity to melanoma.
Cancer Res. 64:1157-1163(2004)

PubMed=15905528; DOI=10.4049/jimmunol.174.11.6863
Yamshchikov G.V., Mullins D.W., Chang C.-C., Ogino T., Thompson L., Presley J., Galavotti H., Aquila W., Deacon D.H., Ross W., Patterson J.W., Engelhard V.H., Ferrone S., Slingluff C.L. Jr.
Sequential immune escape and shifting of T cell responses in a long-term survivor of melanoma.
J. Immunol. 174:6863-6871(2005)

PubMed=20856146; DOI=10.1097/CMR.0b013e32833fafb4
Mikesh L.M., Kumar M., Erdag G., Hogan K.T., Molhoek K.R., Mayo M.W., Slingluff C.L. Jr.
Evaluation of molecular markers of mesenchymal phenotype in melanoma.
Melanoma Res. 20:485-495(2010)

PubMed=21654344; DOI=10.1097/CMR.0b013e328343a1d6
Molhoek K.R., Shada A.L., Smolkin M., Chowbina S., Papin J., Brautigan D.L., Slingluff C.L. Jr.
Comprehensive analysis of receptor tyrosine kinase activation in human melanomas reveals autocrine signaling through IGF-1R.
Melanoma Res. 21:274-284(2011)

PubMed=26405815; DOI=10.1371/journal.pone.0138210
Capaldo B.J., Roller D.G., Axelrod M.J., Koeppel A.F., Petricoin E.F. III, Slingluff C.L. Jr., Weber M.J., Mackey A.J., Gioeli D., Bekiranov S.
Systems analysis of adaptive responses to MAP kinase pathway blockade in BRAF mutant melanoma.
PLoS ONE 10:E0138210-E0138210(2015)

PubMed=26673621; DOI=10.18632/oncotarget.6548
Roller D.G., Capaldo B.J., Bekiranov S., Mackey A.J., Conaway M.R., Petricoin E.F. III, Gioeli D., Weber M.J.
Combinatorial drug screening and molecular profiling reveal diverse mechanisms of intrinsic and adaptive resistance to BRAF inhibition in V600E BRAF mutant melanomas.
Oncotarget 7:2734-2753(2016)

Cross-references
Cell line collections (Providers) ATCC; CRL-3226
Cell line databases/resources cancercelllines; CVCL_A740
Encyclopedic resources Wikidata; Q54993271
Gene expression databases GEO; GSM1672036
GEO; GSM1672041
GEO; GSM1672053
GEO; GSM1672068
GEO; GSM1672080
GEO; GSM1672099
GEO; GSM1672107
GEO; GSM1672112
GEO; GSM1672125
Polymorphism and mutation databases Cosmic; 890886
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number14