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Cellosaurus HSC 536N (CVCL_AK36)

[Text version]
Cell line name HSC 536N
Synonyms HSC-536N; HSC536N; HSC 536/N; HSC/536N; GM13021
Accession CVCL_AK36
Resource Identification Initiative To cite this cell line use: HSC 536N (RRID:CVCL_AK36)
Comments Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; 3584; FANCC; Simple; p.Leu554Pro (c.1661T>C); ClinVar=VCV000012043; Zygosity=Unspecified (Coriell=GM13021).
Disease Fanconi anemia, complementation group C (NCIt: C125704)
Fanconi anemia (ORDO: Orphanet_84)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_G045 (HSC 536)
Sex of cell Male
Age at sampling 5Y
Category Transformed cell line
Publications

PubMed=8822951; DOI=10.1182/blood.V88.6.2298.bloodjournal8862298
Marathi U.K., Howell S.R., Ashmun R.A., Brent T.P.
The Fanconi anemia complementation group C protein corrects DNA interstrand cross-link-specific apoptosis in HSC536N cells.
Blood 88:2298-2305(1996)

PubMed=11926188; DOI=10.1182/blood.V99.7.2627a
Rutherford T.R., Myatt N.E., Gibson F.M., Clarke A.A.
The Fanconi anemia cell line HSC536N is not sensitive to interferon-gamma and does not cleave PARP in response to FAS-mediated cell killing.
Blood 99:2627-2628(2002)

Cross-references
Cell line collections (Providers) Coriell; GM13021
Cell line databases/resources CLO; CLO_0013991
Biological sample resources BioSample; SAMN00802016
Encyclopedic resources Wikidata; Q54896373
Entry history
Entry creation02-May-2016
Last entry update30-Jan-2024
Version number12