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Cellosaurus UOK124 (CVCL_B105)

[Text version]
Cell line name UOK124
Synonyms UOK-124; UOK 124
Accession CVCL_B105
Resource Identification Initiative To cite this cell line use: UOK124 (RRID:CVCL_B105)
Comments Misspelling: Re-124; IARC_TP53=726; Note=Not really a misspelling but an assignment of a name based on first author of publication because assignment of correct cell line name was not done correctly.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Gene fusion; HGNC; 9343; PRCC + HGNC; 11752; TFE3; Name(s)=PRCC-TFE3 (PubMed=8872474).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (PubMed=8319216).
Disease Papillary renal cell carcinoma (NCIt: C6975)
Papillary renal cell carcinoma (ORDO: Orphanet_319298)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_B106 ! UOK124LN
Sex of cell Female
Age at sampling 21Y
Category Cancer cell line
Publications

PubMed=1345811
Anglard P., Trahan E., Liu S., Latif F., Merino M.J., Lerman M.I., Zbar B., Linehan W.M.
Molecular and cellular characterization of human renal cell carcinoma cell lines.
Cancer Res. 52:348-356(1992)

PubMed=8319216
Reiter R.E., Anglard P., Liu S., Gnarra J.R., Linehan W.M.
Chromosome 17p deletions and p53 mutations in renal cell carcinoma.
Cancer Res. 53:3092-3097(1993)

PubMed=7587394; DOI=10.1159/000134127
Shipley J.M., Birdsall S., Clark J., Crew J., Gill S., Linehan W.M., Gnarra J.R., Fisher S., Craig I.W., Cooper C.S.
Mapping the X chromosome breakpoint in two papillary renal cell carcinoma cell lines with a t(X;1)(p11.2;q21.2) and the first report of a female case.
Cytogenet. Cell Genet. 71:280-284(1995)

PubMed=8872474; DOI=10.1093/hmg/5.9.1333
Sidhar S.K., Clark J., Gill S., Hamoudi R., Crew A.J., Gwilliam R., Ross M., Linehan W.M., Birdsall S., Shipley J.M., Cooper C.S.
The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene.
Hum. Mol. Genet. 5:1333-1338(1996)

PubMed=9255309; DOI=10.1016/S0090-4295(97)00220-3
Walther M.M., Kleiner D.E., Lubensky I.A., Pozzatti R., Nyguen T., Gnarra J.R., Hurley K., Venzon D., Linehan W.M., Stetler-Stevenson W.G.
Progelatinase A mRNA expression in cell lines derived from tumors in patients with metastatic renal cell carcinoma correlates inversely with survival.
Urology 50:295-301(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B105
Encyclopedic resources Wikidata; Q54991345
Polymorphism and mutation databases Cosmic; 1330967
Cosmic; 2702366
IARC_TP53; 726
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number15