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Cellosaurus JJ012 (CVCL_D605)

Cell line name JJ012
Synonyms JJO12; JJ
Accession CVCL_D605
Resource Identification Initiative To cite this cell line use: JJ012 (RRID:CVCL_D605)
Comments Doubling time: 0.9 day (PubMed=12168675).
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,02:01
HLA-BB*44:02,44:02
HLA-CC*05:01,05:01
Disease Primary central chondrosarcoma (NCIt: C7155)
Chondrosarcoma (ORDO: Orphanet_55880)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D901 (JJ012-TS4)
Sex of cell Male
Age at sampling 39Y
Category Cancer cell line
STR profile Source(s): PubMed=19787792; PubMed=25877200

Markers:
AmelogeninX (PubMed=25877200)
X,Y (PubMed=19787792)
CSF1PO10
D2S133820,23
D3S135815,16,17,18 (PubMed=25877200)
16,17 (PubMed=19787792)
D5S81811,12
D7S8208,10
D8S117913
D13S31711
D16S53911,12
D18S5115 (PubMed=25877200)
15,17 (PubMed=19787792)
D19S43312,13
D21S1128,29
FGA21,22
Penta D11,13
Penta E7,15
SE3320.2,21
TH016,8
TPOX8,9
vWA15,16 (PubMed=25877200)
15,19 (PubMed=19787792)

Run an STR similarity search on this cell line
Publications

PubMed=8689637; DOI=10.1016/0304-3835(96)04274-7
Jagasia A.A., Block J.A., Qureshi A., Diaz M.O., Nobori T., Gitelis S., Iyer A.P.
Chromosome 9 related aberrations and deletions of the CDKN2 and MTS2 putative tumor suppressor genes in human chondrosarcomas.
Cancer Lett. 105:91-103(1996)

PubMed=10906887; DOI=10.1097/00003086-200007000-00038
Scully S.P., Berend K.R., Toth A., Qi W.-N., Qi Z., Block J.A.
Interstitial collagenase gene expression correlates with in vitro invasion in human chondrosarcoma.
Clin. Orthop. Relat. Res. 376:291-303(2000)

PubMed=12168675; DOI=10.1016/S0736-0266(01)00172-3
Ghert M.A., Qi W.-N., Erickson H.P., Block J.A., Scully S.P.
Tenascin-C expression and distribution in cultured human chondrocytes and chondrosarcoma cells.
J. Orthop. Res. 20:834-841(2002)

PubMed=12354749
Martin J.A., Forest E., Block J.A., Klingelhutz A.J., Whited B., Gitelis S., Wilkey A., Buckwalter J.A.
Malignant transformation in human chondrosarcoma cells supported by telomerase activation and tumor suppressor inactivation.
Cell Growth Differ. 13:397-407(2002)

PubMed=19787792; DOI=10.1002/gcc.20717
Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S.E., Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H., Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W., Buerger H., Aigner T., Gabbert H.E., Poremba C.
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Genes Chromosomes Cancer 49:40-51(2010)

PubMed=22057234; DOI=10.1038/ng.1004
Pansuriya T.C., van Eijk R., d'Adamo P., van Ruler M.A.J.H., Kuijjer M.L., Oosting J., Cleton-Jansen A.-M., van Oosterwijk J.G., Verbeke S.L.J., Meijer D., van Wezel T., Nord K.H., Sangiorgi L., Toker B., Liegl-Atzwanger B., San-Julian M., Sciot R., Limaye N., Kindblom L.-G., Daugaard S., Godfraind C., Boon L.M., Vikkula M., Kurek K.C., Szuhai K., French P.J., Bovee J.V.M.G.
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome.
Nat. Genet. 43:1256-1261(2011)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26368816; DOI=10.1371/journal.pone.0133813
Li L.-Y., Paz A.C., Wilky B.A., Johnson B., Galoian K., Rosenberg A., Hu G.-Z., Tinoco G., Bodamer O.A., Trent J.C. II
Treatment with a small molecule mutant IDH1 inhibitor suppresses tumorigenic activity and decreases production of the oncometabolite 2-hydroxyglutarate in human chondrosarcoma cells.
PLoS ONE 10:E0133813-E0133813(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D605
Anatomy/cell type resources BTO; BTO:0005168
Biological sample resources BioSample; SAMN03470880
Chemistry resources PharmacoDB; JJ012_705_2019
Encyclopedic resources Wikidata; Q54898950
Experimental variables resources EFO; EFO_0006604
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM1676351
GEO; GSM1701681
Polymorphism and mutation databases Cosmic; 1602476
Cosmic; 1992323
IARC_TP53; 27035
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number26