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Cellosaurus UCSD237i-APP1-2 (CVCL_EJ97)

[Text version]
Cell line name UCSD237i-APP1-2
Synonyms APPDp1.2; Appdp1.2; APPdp1.2
Accession CVCL_EJ97
Resource Identification Initiative To cite this cell line use: UCSD237i-APP1-2 (RRID:CVCL_EJ97)
Comments Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Familial Alzheimer's disease, type 1 (NCIt: C146894)
Early-onset autosomal dominant Alzheimer disease (ORDO: Orphanet_1020)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UI23 (UCSD237i-APP1-2 APPnull)
Originate from same individual CVCL_EJ96 ! UCSD236i-APP1-1
CVCL_EJ98 ! UCSD238i-APP1-3
Sex of cell Male
Age at sampling 51Y
Category Induced pluripotent stem cell
Publications

PubMed=22278060; DOI=10.1038/nature10821
Israel M.A., Yuan S.H., Bardy C., Reyna S.M., Mu Y.-L., Herrera C.M., Hefferan M.P., Van Gorp S.F.J., Nazor K.L., Boscolo F.S., Carson C.T., Laurent L.C., Marsala M., Gage F.H., Remes A.M., Koo E.H., Goldstein L.S.B.
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.
Nature 482:216-220(2012)

PubMed=30686764; DOI=10.1016/j.stem.2018.12.013
van der Kant R., Langness V.F., Herrera C.M., Williams D.A., Fong L.K., Leestemaker Y., Steenvoorden E., Rynearson K.D., Brouwers J.F., Helms J.B., Ovaa H., Giera M., Wagner S.L., Bang A.G., Goldstein L.S.B.
Cholesterol metabolism is a druggable axis that independently regulates Tau and amyloid-beta in iPSC-derived Alzheimer's disease neurons.
Cell Stem Cell 24:363-375.e9(2019)

Cross-references
Cell line collections (Providers) WiCell; ucsd237i-app1-2 - Discontinued
Cell line databases/resources SKIP; SKIP005444
Encyclopedic resources Wikidata; Q54990043
Entry history
Entry creation26-Sep-2016
Last entry update29-Jun-2023
Version number13