| Cell line name |
IGROV-1/Pt0.5 |
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| Synonyms |
IGROV-1/Pt 0.5; IGROV1/Pt0.5 |
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| Accession |
CVCL_EQ61 |
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| Resource Identification Initiative |
To cite this cell line use: IGROV-1/Pt0.5 (RRID:CVCL_EQ61) |
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| Comments |
Population: Caucasian.
Doubling time: 36 +- 2.2 hours (PubMed=9636834).
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992. |
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| Sequence variations |
- Mutation; HGNC; 1100; BRCA1; Simple; p.Lys654Serfs*47 (c.1961delA); ClinVar=VCV000037438; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1101; BRCA2; Simple; p.Lys1108Argfs*11 (c.3323delA) (p.Gln1107fs) (c.3320delA); ClinVar=VCV000225716; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Arg38Cys (c.112C>T); ClinVar=VCV000376493; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Ter1069TrpinsLysAspAsn (c.3207A>G); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Thr319fs*1 (c.955_958delACTT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9884; RB1; Simple; p.Val654Cysfs*4 (c.1959delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Gly231Alafs*10 (c.692delG); ClinVar=VCV001756201; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Leu495Pro (c.1484T>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Ser90Leufs*59 (c.267dupC) (c.267_268insC); ClinVar=VCV000634762; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Cys (c.377A>G); ClinVar=VCV000458541; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Phe270Leu (c.808T>C); ClinVar=VCV000634778; Zygosity=Heterozygous (PubMed=8564971).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg282Trp (c.844C>T); ClinVar=VCV000012364; Zygosity=Heterozygous (PubMed=8564971).
|
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| Disease |
Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1304 (IGROV-1) |
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| Sex of cell |
Female |
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| Age at sampling |
47Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=8564971
Perego P., Giarola M., Righetti S.C., Supino R., Caserini C., Delia D., Pierotti M.A., Miyashita T., Reed J.C., Zunino F.
Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems.
Cancer Res. 56:556-562(1996) PubMed=9636834; DOI=10.1023/A:1008265012435
Perego P., Romanelli S., Carenini N., Magnani I., Leone R., Bonetti A., Paolicchi A., Zunino F.
Ovarian cancer cisplatin-resistant cell lines: multiple changes including collateral sensitivity to taxol.
Ann. Oncol. 9:423-430(1998) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_EQ61
|
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| Encyclopedic resources |
Wikidata; Q54897387
|
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| Polymorphism and mutation databases |
IARC_TP53; 5443
|
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| Entry history |
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| Entry creation | 26-Sep-2016 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 16 |
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