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Cellosaurus TS/A (CVCL_F736)

[Text version]
Cell line name TS/A
Synonyms TSA
Accession CVCL_F736
Resource Identification Initiative To cite this cell line use: TS/A (RRID:CVCL_F736)
Comments Characteristics: Metastatic. When injected subcutaneously into syngeneic BALB/c mice, give rise to local tumors rapidly disseminating to the lungs.
Karyotypic information: Triploid karyotype (PubMed=15004469).
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Sequence variations
  • Mutation; MGI; MGI:98834; Trp53; Simple; p.Arg270His (c.809G>A); Zygosity=Unspecified (PubMed=11263530).
Disease Malignant neoplasms of the mouse mammary gland (NCIt: C21678)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/cAnNCrlBR.
Hierarchy Children:
CVCL_2A40 (Col-1)CVCL_4559 (Meta 1)CVCL_L871 (TS/A clone E1)
CVCL_L872 (TS/A clone E2)CVCL_L873 (TS/A clone E3)CVCL_L874 (TS/A clone F1)
CVCL_L875 (TS/A clone F2)CVCL_L876 (TS/A clone F5)CVCL_VQ63 (TS/A-pc)
Sex of cell Female
Age at sampling 1Y8M
Category Cancer cell line
STR profile Source(s): Millipore

Markers:
Mouse STR 1-115
Mouse STR 1-217
Mouse STR 2-116
Mouse STR 3-214
Mouse STR 4-221.3
Mouse STR 5-514
Mouse STR 6-417
Mouse STR 6-712
Mouse STR 7-125.1
Mouse STR 8-113
Mouse STR 11-217
Mouse STR 12-116
Mouse STR 13-115.2,16.2
Mouse STR 15-322.3
Mouse STR 17-217
Mouse STR 18-318,19
Mouse STR 19-213,15
Mouse STR X-124,25

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/TS/A
http://www.lollini.it/tsa.htm
Publications

PubMed=6546207; DOI=10.1007/BF00121199
Nanni P., De Giovanni C., Lollini P.-L., Nicoletti G., Prodi G.
TS/A: a new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma.
Clin. Exp. Metastasis 1:373-380(1983)

PubMed=3875361; DOI=10.1038/bjc.1985.180
Nicoletti G., Brambilla P., De Giovanni C., Lollini P.-L., Del Re B., Marocchi A., Mocarelli P., Prodi G., Nanni P.
Colony-stimulating activity from the new metastatic TS/A cell line and its high- and low-metastatic clonal derivatives.
Br. J. Cancer 52:215-222(1985)

PubMed=3455746; DOI=10.1093/jnci/76.1.87
Nanni P., De Giovanni C., Lollini P.-L., Nicoletti G., Prodi G.
Clones with different metastatic capacity and variant selection during metastasis: a problematic relationship.
J. Natl. Cancer Inst. 76:87-93(1986)

PubMed=11263530; DOI=10.1038/sj.cgt.7700279
Odin L., Favrot M.-C., Poujol D., Michot J.-P., Moingeon P., Tartaglia J., Puisieux I.
Canarypox virus expressing wild type p53 for gene therapy in murine tumors mutated in p53.
Cancer Gene Ther. 8:87-98(2001)

PubMed=15004469; DOI=10.1159/000076294
Jentsch I., Geigl J., Klein C.A., Speicher M.R.
Seven-fluorochrome mouse M-FISH for high-resolution analysis of interchromosomal rearrangements.
Cytogenet. Genome Res. 103:84-88(2003)

PubMed=31783695; DOI=10.3390/cancers11121889
De Giovanni C., Nicoletti G., Landuzzi L., Palladini A., Lollini P.-L., Nanni P.
Bioprofiling TS/A murine mammary cancer for a functional precision experimental model.
Cancers (Basel) 11:1889.1-1889.20(2019)

Cross-references
Cell line collections (Providers) Millipore; SCC177
Cell line databases/resources CLO; CLO_0009405
CLDB; cl4545
Lonza; 103
Anatomy/cell type resources BTO; BTO:0004282
Chemistry resources ChEMBL-Cells; CHEMBL3308478
ChEMBL-Targets; CHEMBL615017
PubChem_Cell_line; CVCL_F736
Encyclopedic resources Wikidata; Q50433109
Entry history
Entry creation11-Feb-2013
Last entry update29-Jun-2023
Version number16