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Cellosaurus FU-266 clone E1 (CVCL_J236)

[Text version]
Cell line name FU-266 clone E1
Synonyms FU-266 (E1)
Accession CVCL_J236
Resource Identification Initiative To cite this cell line use: FU-266 clone E1 (RRID:CVCL_J236)
Comments Population: Caucasian.
Characteristics: Produces IgE lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Lys601Asn (c.1803A>T); ClinVar=VCV000376285; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Gly141Asp (c.422G>A); ClinVar=VCV001491786; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 12033; TRAF3; Simple; p.Lys550Leufs*3 (c.1648_1649insT); Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_J235 (FU-266)
Children:
CVCL_9087 (36)CVCL_9088 (SHM-A6)CVCL_3419 (SHM-D33)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=6316357; DOI=10.1073/pnas.80.23.7308
Teng N.N.H., Lam K.S., Calvo Riera F., Kaplan H.S.
Construction and testing of mouse -- human heteromyelomas for human monoclonal antibody production.
Proc. Natl. Acad. Sci. U.S.A. 80:7308-7312(1983)

Patent=US4574116
Kaplan H.S., Teng N.N.H., Lam K.S., Calvo-Riera F.
Methods and cell lines for immortalization and monoclonal antibody production by antigen-stimulated B-lymphocytes.
Patent number US4574116, 04-Mar-1986

Cross-references
Encyclopedic resources Wikidata; Q54835232
Entry history
Entry creation11-Feb-2013
Last entry update05-Oct-2023
Version number13