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Cellosaurus LPS141 (CVCL_M823)

Cell line name LPS141
Synonyms LS141
Accession CVCL_M823
Resource Identification Initiative To cite this cell line use: LPS141 (RRID:CVCL_M823)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
From: Fletcher J.A.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School; Boston; USA.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Disease Dedifferentiated liposarcoma (NCIt: C3704)
Dedifferentiated liposarcoma (ORDO: Orphanet_99970)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): DepMap

Markers:
AmelogeninX
CSF1PO11,12
D3S135817
D5S81812
D7S82011,12
D8S117911,13
D13S31713
D16S53912,14
D18S5111,14
D21S1128,29
FGA23
Penta D9,13
Penta E11,12
TH019.3
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=19449367; DOI=10.1002/path.2564
Snyder E.L., Sandstrom D.J., Law K., Fiore C., Sicinska E.T., Brito J., Bailey D., Fletcher J.A., Loda M., Rodig S.J., Dal Cin P.S., Fletcher C.D.M.
c-Jun amplification and overexpression are oncogenic in liposarcoma but not always sufficient to inhibit the adipocytic differentiation programme.
J. Pathol. 218:292-300(2009)

PubMed=19706776; DOI=10.1158/0008-5472.CAN-08-4004
Muhlenberg T., Zhang Y.-X., Wagner A.J., Grabellus F., Bradner J., Taeger G., Lang H., Taguchi T., Schuler M., Fletcher J.A., Bauer S.
Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.
Cancer Res. 69:6941-6950(2009)

PubMed=20713527; DOI=10.1158/0008-5472.CAN-10-0745
Brill E.R., Gobble R.M., Angeles C.V., Lagos-Quintana M., Crago A., Laxa B.U., DeCarolis P.L., Zhang L., Antonescu C.R., Socci N.D., Taylor B.S., Sander C., Koff A., Singer S.
ZIC1 overexpression is oncogenic in liposarcoma.
Cancer Res. 70:6891-6901(2010)

PubMed=21335544; DOI=10.1158/0008-5472.CAN-10-3588
Gobble R.M., Qin L.-X., Brill E.R., Angeles C.V., Ugras S., O'Connor R.B., Moraco N.H., DeCarolis P.L., Antonescu C.R., Singer S.
Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis.
Cancer Res. 71:2697-2705(2011)

PubMed=21693658; DOI=10.1158/0008-5472.CAN-11-0890
Ugras S., Brill E.R., Jacobsen A., Hafner M., Socci N.D., DeCarolis P.L., Khanin R., O'Connor R.B., Mihailovic A., Taylor B.S., Sheridan R., Gimble J.M., Viale A.J., Crago A., Antonescu C.R., Sander C., Tuschl T., Singer S.
Small RNA sequencing and functional characterization reveals MicroRNA-143 tumor suppressor activity in liposarcoma.
Cancer Res. 71:5659-5669(2011)

PubMed=22328974; DOI=10.1158/2159-8290.CD-11-0181
Taylor B.S., DeCarolis P.L., Angeles C.V., Brenet F., Schultz N., Antonescu C.R., Scandura J.M., Sander C., Viale A.J., Socci N.D., Singer S.
Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas.
Cancer Discov. 1:587-597(2011)

PubMed=22170698; DOI=10.1002/gcc.21917
Wu Y.V., Okada T., DeCarolis P.L., Socci N.D., O'Connor R.B., Geha R.C., Somberg C.J., Antonescu C.R., Singer S.
Restoration of C/EBPalpha in dedifferentiated liposarcoma induces G2/M cell cycle arrest and apoptosis.
Genes Chromosomes Cancer 51:313-327(2012)

PubMed=22911243; DOI=10.1155/2012/148614
Stratford E.W., Castro R., Daffinrud J., Skarn M., Lauvrak S., Munthe E., Myklebost O.
Characterization of liposarcoma cell lines for preclinical and biological studies.
Sarcoma 2012:148614.1-148614.9(2012)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=26643872; DOI=10.18632/oncotarget.6464
Kanojia D., Nagata Y., Garg M., Lee D.H., Sato A., Yoshida K., Sato Y., Sanada M., Mayakonda A., Bartenhagen C., Klein H.-U., Doan N.B., Said J.W., Mohith S., Gunasekar S., Shiraishi Y., Chiba K., Tanaka H., Miyano S., Myklebost O., Yang H., Dugas M., Meza-Zepeda L.A., Silberman A.W., Forscher C., Tyner J.W., Ogawa S., Koeffler H.P.
Genomic landscape of liposarcoma.
Oncotarget 6:42429-42444(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M823
Cell_Model_Passport; SIDM01796
DepMap; ACH-001799
Encyclopedic resources Wikidata; Q54902989
Gene expression databases GEO; GSM529098
GEO; GSM1228009
GEO; GSM1676337
GEO; GSM1701669
Polymorphism and mutation databases Cosmic; 2800523
Progenetix; CVCL_M823
Entry history
Entry creation05-Nov-2013
Last entry update05-Oct-2023
Version number17