| Publications | PubMed=7433105; DOI=10.1093/nar/8.16.3709
Houldsworth J., Lavin M.F.
Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells.
Nucleic Acids Res. 8:3709-3720(1980) PubMed=1944384; DOI=10.1016/0921-8734(91)90029-B
Chen P., Kidson C., Lavin M.F.
Heterogeneity in Alzheimer's disease: evidence from cellular radiosensitivity and complementation of this phenotype.
Mutat. Res. 256:21-27(1991) PubMed=9150358; DOI=10.1038/sj.onc.1201037
Watters D., Khanna K.K., Beamish H.J., Birrell G., Spring K., Kedar P., Gatei M., Stenzel D., Hobson K., Kozlov S., Zhang N., Farrell A., Ramsay J., Gatti R.A., Lavin M.F.
Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms.
Oncogene 14:1911-1921(1997) PubMed=11080496; DOI=10.1074/jbc.M006190200
Gueven N., Keating K.E., Chen P., Fukao T., Khanna K.K., Watters D., Rodemann P.H., Lavin M.F.
Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia.
J. Biol. Chem. 276:8884-8891(2001) PubMed=12195425; DOI=10.1038/ng958
Spring K., Ahangari F., Scott S.P., Waring P., Purdie D.M., Chen P.C., Hourigan K., Ramsay J., McKinnon P.J., Swift M., Lavin M.F.
Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer.
Nat. Genet. 32:185-190(2002) PubMed=12645530; DOI=10.1074/jbc.M300003200
Kozlov S., Gueven N., Keating K.E., Ramsay J., Lavin M.F.
ATP activates ataxia-telangiectasia mutated (ATM) in vitro Importance of autophosphorylation.
J. Biol. Chem. 278:9309-9317(2003) PubMed=15044383; DOI=10.1093/hmg/ddh122
Gueven N., Becherel O.J., Kijas A.W., Chen P., Howe O., Rudolph J.H., Gatti R.A., Date H., Onodera O., Taucher-Scholz G., Lavin M.F.
Aprataxin, a novel protein that protects against genotoxic stress.
Hum. Mol. Genet. 13:1081-1093(2004) PubMed=16540636; DOI=10.1158/0008-5472.CAN-05-3428
Gueven N., Becherel O.J., Birrell G., Chen P., DelSal G., Carney J.P., Grattan-Smith P., Lavin M.F.
Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.
Cancer Res. 66:2907-2912(2006) PubMed=17347666; DOI=10.1038/sj.cdd.4402116
Gueven N., Becherel O.J., Howe O., Chen P., Haince J.-F., Ouellet M.-E., Poirier G.G., Waterhouse N., Fusser M., Epe B., de Murcia J.M., de Murcia G., McGowan C.H., Parton R., Mothersill C., Grattan-Smith P., Lavin M.F.
A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance.
Cell Death Differ. 14:1149-1161(2007) PubMed=17562789; DOI=10.1083/jcb.200701042
Suraweera A., Becherel O.J., Chen P., Rundle N., Woods R., Nakamura J., Gatei M., Criscuolo C., Filla A., Chessa L., Fusser M., Epe B., Gueven N., Lavin M.F.
Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage.
J. Cell Biol. 177:969-979(2007) PubMed=19643912; DOI=10.1093/hmg/ddp359
Harris J.L., Jakob B., Taucher-Scholz G., Dianov G.L., Becherel O.J., Lavin M.F.
Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage.
Hum. Mol. Genet. 18:4102-4117(2009) PubMed=21149446; DOI=10.1074/jbc.M110.204065
Kozlov S.V., Graham M.E., Jakob B., Tobias F., Kijas A.W., Tanuji M., Chen P., Robinson P.J., Taucher-Scholz G., Suzuki K., So S., Chen D., Lavin M.F.
Autophosphorylation and ATM activation: additional sites add to the complexity.
J. Biol. Chem. 286:9107-9119(2011) PubMed=25868131; DOI=10.1016/j.mrgentox.2015.03.012
Kobayashi J., Saito Y., Okui M., Miwa N., Komatsu K.
Increased oxidative stress in AOA3 cells disturbs ATM-dependent DNA damage responses.
Mutat. Res. 782:42-50(2015) |
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