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Cellosaurus SNU-2535 (CVCL_R756)

[Text version]
Cell line name SNU-2535
Accession CVCL_R756
Resource Identification Initiative To cite this cell line use: SNU-2535 (RRID:CVCL_R756)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Seoul National University (SNU) cell line collection.
Population: Korean.
Characteristics: Resistant to crizotinib (PubMed=23344087).
Doubling time: 61 hours (CelloPub=CLPUB00546).
Omics: Deep exome analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 427; ALK + HGNC; 1316; EML4; Name(s)=EML4-ALK (CelloPub=CLPUB00546; PubMed=35852680).
  • Mutation; HGNC; 427; ALK; Simple; p.Gly1269Ala (c.3806G>C); ClinVar=VCV000376132; Zygosity=Heterozygous (CelloPub=CLPUB00546; PubMed=35852680; DepMap).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C5TR (SNU-2535LR)
Sex of cell Female
Age at sampling 57Y
Category Cancer cell line
STR profile Source(s): KCLB; CelloPub=CLPUB00546

Markers:
AmelogeninX
CSF1PO11
D2S133820,23
D3S135814,15 (CelloPub=CLPUB00546)
15 (KCLB)
D5S81810,12
D7S82011
D8S117913,15
D13S3179,11
D16S5399,11
D18S5115
D19S43310.2,14
D21S1128,29
FGA24,27
TH017,9.3
TPOX11
vWA16,17

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Publications

PubMed=23344087; DOI=10.1097/JTO.0b013e318283dcc0
Kim S., Kim T.M., Kim D.-W., Go H., Keam B., Lee S.-H., Ku J.-L., Chung D.H., Heo D.S.
Heterogeneity of genetic changes associated with acquired crizotinib resistance in ALK-rearranged lung cancer.
J. Thorac. Oncol. 8:415-422(2013)

CLPUB00546
Seo H.-Y.
Establishment and characterization of 28 human lung cancer cell lines derived from pleural effusions.
Thesis MSc (2019), Seoul National University College of Medicine, South Korea

PubMed=35852680; DOI=10.1007/s12094-022-02884-x
Xie B., Qiu Y., Zhou J., Du D., Ma H.-C., Ji J.-P., Zhu L.-Q., Zhang W.-M.
Establishment of an acquired lorlatinib-resistant cell line of non-small cell lung cancer and its mediated resistance mechanism.
Clin. Transl. Oncol. 24:2231-2240(2022)

Cross-references
Cell line collections (Providers) KCLB; 02535
Cell line databases/resources cancercelllines; CVCL_R756
DepMap; ACH-002531
Encyclopedic resources Wikidata; Q54955156
Polymorphism and mutation databases Cosmic; 1859888
Entry history
Entry creation05-Nov-2013
Last entry update05-Oct-2023
Version number16