UniProtKB/Swiss-Prot protein knowledgebase release 2017_06 statistics





1.  INTRODUCTION



Release 2017_06 of 07-Jun-17 of UniProtKB/Swiss-Prot contains 554860 sequence entries,

comprising 198649153 amino acids abstracted from 253168 references. 



351 sequences have been added since release 2017_05, the sequence data of

32 existing entries has been updated and the annotations of

419699 entries have been revised.



Number of fragments: 9137

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 39584





Protein existence (PE):           entries     %



1: Evidence at protein level        95492   17.2%

2: Evidence at transcript level     57660   10.4%

3: Inferred from homology          386124   69.6%

4: Predicted                        13727    2.5%

5: Uncertain                         1857    0.3%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 13456



   The first twenty species represent 119281 sequences:  21.5 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5587

                            2x: 1922

                            3x: 1052

                            4x:  670

                            5x:  496

                            6x:  406

                            7x:  286

                            8x:  240

                            9x:  231

                           10x:  135

                       11- 20x:  723

                       21- 50x:  442

                       51-100x:  217

                         >100x: 1049





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20205  Homo sapiens (Human)

       2      16894  Mus musculus (Mouse)

       3      15383  Arabidopsis thaliana (Mouse-ear cress)

       4       7991  Rattus norvegicus (Rat)

       5       6721  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       5999  Bos taurus (Bovine)

       7       5141  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4435  Escherichia coli (strain K12)

       9       4185  Bacillus subtilis (strain 168)

      10       4134  Dictyostelium discoideum (Slime mold)

      11       3908  Caenorhabditis elegans

      12       3800  Oryza sativa subsp. japonica (Rice)

      13       3466  Drosophila melanogaster (Fruit fly)

      14       3410  Xenopus laevis (African clawed frog)

      15       3007  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2286  Gallus gallus (Chicken)

      17       2219  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      18       2166  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

      19       2033  Escherichia coli O157:H7

      20       1898  Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

      21       1795  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1787  Methanocaldococcus jannaschii  

      23       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      24       1704  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      25       1694  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      26       1681  Shigella flexneri

      27       1419  Sus scrofa (Pig)

      28       1347  Salmonella typhi

      29       1310  Pseudomonas aeruginosa 

      30       1244  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      31       1172  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      32       1063  Synechocystis sp. (strain PCC 6803 / Kazusa)

      33       1029  Archaeoglobus fulgidus 

      34       1022  Yersinia pestis

      35       1003  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      36        975  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      37        930  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      38        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      39        927  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      40        926  Staphylococcus aureus (strain N315)

      41        910  Kluyveromyces lactis   

      42        909  Acanthamoeba polyphaga mimivirus (APMV)

      43        899  Staphylococcus aureus (strain COL)

      44        895  Staphylococcus aureus (strain MW2)

      45        892  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      46        892  Oryctolagus cuniculus (Rabbit)

      47        889  Staphylococcus aureus (strain MSSA476)

      48        888  Staphylococcus aureus (strain MRSA252)

      49        882  Salmonella choleraesuis (strain SC-B67)

      50        879  Shigella sonnei (strain Ss046)

      51        878  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      52        874  Emericella nidulans  

      53        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      54        862  Candida glabrata   

      55        854  Neurospora crassa 

      56        841  Escherichia coli O9:H4 (strain HS)

      57        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      58        829  Shigella boydii serotype 4 (strain Sb227)

      59        825  Escherichia coli (strain UTI89 / UPEC)

      60        822  Shigella dysenteriae serotype 1 (strain Sd197)

      61        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      62        816  Canis lupus familiaris (Dog) (Canis familiaris)

      63        809  Oryza sativa subsp. indica (Rice)

      64        796  Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 

      65        791  Escherichia coli (strain SMS-3-5 / SECEC)

      66        789  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      67        784  Aquifex aeolicus (strain VF5)

      68        780  Zea mays (Maize)

      69        776  Pasteurella multocida (strain Pm70)

      70        774  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      71        771  Escherichia coli (strain K12 / DH10B)

      72        771  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      73        765  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      74        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      75        762  Escherichia coli (strain 55989 / EAEC)

      76        761  Escherichia coli O8 (strain IAI1)

      77        760  Shigella flexneri serotype 5b (strain 8401)

      78        760  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      79        760  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

      80        759  Staphylococcus epidermidis (strain ATCC 12228)

      81        757  Staphylococcus aureus (strain NCTC 8325)

      82        756  Escherichia coli (strain SE11)

      83        756  Escherichia coli O45:K1 (strain S88 / ExPEC)

      84        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      85        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      86        745  Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

      87        741  Bacillus anthracis

      88        741  Bacillus halodurans 

      89        737  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      90        733  Vibrio vulnificus (strain CMCP6)

      91        731  Escherichia coli O81 (strain ED1a)

      92        722  Salmonella enteritidis PT4 (strain P125109)

      93        718  Vibrio vulnificus (strain YJ016)

      94        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      95        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      96        715  Enterobacter sp. (strain 638)

      97        714  Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

      98        714  Escherichia coli O1:K1 / APEC

      99        714  Salmonella paratyphi A (strain AKU_12601)

     100        713  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

     101        713  Salmonella agona (strain SL483)

     102        713  Salmonella newport (strain SL254)

     103        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     104        712  Salmonella schwarzengrund (strain CVM19633)

     105        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     106        710  Salmonella heidelberg (strain SL476)

     107        702  Salmonella dublin (strain CT_02021853)

     108        698  Klebsiella pneumoniae (strain 342)

     109        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     110        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     111        693  Pan troglodytes (Chimpanzee)

     112        692  Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

     113        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     114        684  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     115        679  Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

     116        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     117        673  Staphylococcus aureus (strain USA300)

     118        670  Serratia proteamaculans (strain 568)

     119        670  Escherichia coli

     120        669  Mycobacterium leprae (strain TN)

     121        667  Yersinia pestis (strain Pestoides F)

     122        665  Bacillus cereus 

     123        662  Bradyrhizobium diazoefficiens 

     124        658  Sinorhizobium fredii (strain NBRC 101917 / NGR234)

     125        653  Debaryomyces hansenii   

     126        650  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     127        645  Shewanella oneidensis (strain MR-1)

     128        645  Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 

     129        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     130        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     131        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     132        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     133        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     134        620  Methanothermobacter thermautotrophicus  

     135        620  Treponema pallidum (strain Nichols)

     136        613  Staphylococcus haemolyticus (strain JCSC1435)

     137        610  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)

     138        609  Xanthomonas campestris pv. campestris 

     139        607  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     140        603  Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)

     141        603  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     142        602  Photobacterium profundum (strain SS9)

     143        602  Staphylococcus saprophyticus subsp. saprophyticus 

     144        601  Salmonella paratyphi C (strain RKS4594)

     145        600  Yersinia pestis bv. Antiqua (strain Angola)

     146        594  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     147        593  Bacillus cereus (strain ATCC 10987 / NRS 248)

     148        591  Pseudomonas aeruginosa (strain UCBPP-PA14)

     149        591  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     150        586  Rickettsia prowazekii (strain Madrid E)

     151        580  Neisseria meningitidis serogroup B (strain MC58)

     152        579  Brucella suis biovar 1 (strain 1330)

     153        577  Caenorhabditis briggsae

     154        574  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     155        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     156        569  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     157        568  Caulobacter crescentus (strain ATCC 19089 / CB15)

     158        568  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     159        567  Vibrio fischeri (strain ATCC 700601 / ES114)

     160        567  Pseudomonas syringae pv. syringae (strain B728a)

     161        564  Bacillus licheniformis 

     162        562  Bacillus cereus (strain ZK / E33L)

     163        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     164        559  Clostridium acetobutylicum 

     165        556  Xanthomonas axonopodis pv. citri (strain 306)

     166        553  Oceanobacillus iheyensis 

     167        553  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

     168        552  Pseudomonas fluorescens (strain Pf0-1)

     169        549  Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

     170        547  Pseudomonas savastanoi pv. phaseolicola  (Pseudomonas syringae pv. phaseolicola 

     171        546  Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

     172        545  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     173        536  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     174        531  Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

     175        529  Sodalis glossinidius (strain morsitans)

     176        529  Listeria monocytogenes serotype 4b (strain F2365)

     177        527  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     178        522  Xylella fastidiosa (strain 9a5c)

     179        518  Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

     180        518  Corynebacterium glutamicum 

     181        517  Chromobacterium violaceum 

     182        516  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     183        515  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     184        513  Deinococcus radiodurans 

     185        512  Pseudomonas aeruginosa (strain PA7)

     186        511  Staphylococcus aureus (strain Newman)

     187        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     188        510  Geobacillus kaustophilus (strain HTA426)

     189        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     190        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     191        507  Streptomyces avermitilis 

     192        502  Pseudomonas entomophila (strain L48)

     193        501  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     194        499  Brucella abortus biovar 1 (strain 9-941)

     195        497  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     196        497  Haemophilus influenzae (strain 86-028NP)

     197        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     198        496  Bacillus clausii (strain KSM-K16)

     199        495  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     200        495  Burkholderia pseudomallei (strain K96243)

     201        494  Proteus mirabilis (strain HI4320)

     202        493  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     203        493  Xanthomonas campestris pv. campestris (strain 8004)

     204        492  Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) 

     205        491  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     206        490  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     207        490  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     208        487  Methanosarcina mazei  

     209        487  Shewanella sp. (strain MR-7)

     210        486  Mannheimia succiniciproducens (strain MBEL55E)

     211        484  Pseudomonas aeruginosa (strain LESB58)

     212        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     213        484  Thermosynechococcus elongatus (strain BP-1)

     214        484  Shewanella sp. (strain MR-4)

     215        483  Brucella abortus (strain 2308)

     216        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     217        482  Pyrococcus horikoshii 

     218        479  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     219        479  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)

     220        478  Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

     221        477  Pyrococcus abyssi (strain GE5 / Orsay)

     222        474  Burkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)

     223        474  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 

     224        471  Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

     225        470  Nicotiana tabacum (Common tobacco)

     226        468  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     227        468  Clostridium perfringens (strain 13 / Type A)

     228        466  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     229        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     230        466  Shewanella frigidimarina (strain NCIMB 400)

     231        466  Pseudomonas putida (strain GB-1)

     232        466  Shewanella sp. (strain ANA-3)

     233        464  Aeromonas hydrophila subsp. hydrophila 

     234        464  Anabaena variabilis (strain ATCC 29413 / PCC 7937)

     235        462  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     236        462  Burkholderia mallei (strain ATCC 23344)

     237        462  Enterococcus faecalis (strain ATCC 700802 / V583)

     238        461  Campylobacter jejuni subsp. jejuni serotype O:2 

     239        459  Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha 

     240        458  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     241        457  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     242        456  Ovis aries (Sheep)

     243        455  Staphylococcus aureus (strain JH1)

     244        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     245        453  Pseudomonas putida (strain W619)

     246        452  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

     247        452  Aeromonas salmonicida (strain A449)

     248        452  Shewanella baltica (strain OS185)

     249        450  Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)

     250        450  Dechloromonas aromatica (strain RCB)





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19462 (  4%)

    Bacteria         333104 ( 60%)

    Eukaryota        185570 ( 33%)

    Viruses           16724 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20206 ( 11%)           (  4%)

     Other Mammalia         46478 ( 25%)           (  8%)

     Other Vertebrata       18086 ( 10%)           (  3%)

     Viridiplantae          38851 ( 21%)           (  7%)

     Fungi                  32702 ( 18%)           (  6%)

     Insecta                 9062 (  5%)           (  2%)

     Nematoda                4798 (  3%)           (  1%)

     Other                  15387 (  8%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9256             1001-1100     3941

                 51- 100   42299             1101-1200     2766

                101- 150   58757             1201-1300     2125

                151- 200   58680             1301-1400     1976

                201- 250   57505             1401-1500     1581

                251- 300   51182             1501-1600      775

                301- 350   51519             1601-1700      601

                351- 400   44693             1701-1800      522

                401- 450   36714             1801-1900      459

                451- 500   29541             1901-2000      369

                501- 550   21225             2001-2100      241

                551- 600   15163             2101-2200      318

                601- 650   12684             2201-2300      305

                651- 700    9145             2301-2400      198

                701- 750    7601             2401-2500      153

                751- 800    5440             >2500         1203

                801- 850    4725

                851- 900    5175

                901- 950    4006

                951-1000    2880



   





   The average sequence length in UniProtKB/Swiss-Prot is 358 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2668





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  857

                       2x:  364

                       3x:  167

                       4x:  131

                       5x:  102

                       6x:   96

                       7x:   60

                       8x:   52

                       9x:   39

                      10x:   30

                  11- 20x:  214

                  21- 50x:  217

                  51-100x:  118

                    >100x:  221





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        23771   Journal of Biological Chemistry

    2        10928   Proceedings of the National Academy of Sciences of the U.S.A.

    3         6422   Journal of Bacteriology

    4         5476   Biochemical and Biophysical Research Communications

    5         5120   Biochemistry

    6         4913   Nucleic Acids Research

    7         4782   Gene

    8         4728   FEBS Letters

    9         4579   The EMBO Journal

   10         4293   Nature

   11         4269   Molecular and Cellular Biology

   12         4125   Journal of Molecular Biology

   13         3539   Biochimica et Biophysica Acta

   14         3443   Cell

   15         3363   European Journal of Biochemistry

   16         3011   Journal of Virology

   17         2883   Science

   18         2778   Biochemical Journal

   19         2528   Genomics

   20         2419   Molecular Microbiology

   21         2417   Plant Physiology

   22         2115   Journal of Cell Biology

   23         2036   The American Journal of Human Genetics

   24         1876   The Plant Cell

   25         1819   Plant Molecular Biology

   26         1786   Genes and Development

   27         1737   Human Molecular Genetics

   28         1730   The Plant Journal

   29         1698   Virology

   30         1694   Nature Genetics

   31         1612   PLoS ONE

   32         1605   Development

   33         1595   Molecular Biology of the Cell

   34         1525   Human Mutation

   35         1521   Oncogene

   36         1432   Molecular Cell

   37         1388   Molecular and General Genetics

   38         1355   Journal of Immunology

   39         1320   Journal of Biochemistry

   40         1272   Structure

   41         1260   Genetics

   42         1175   Journal of Cell Science

   43         1114   Blood

   44         1097   Journal of General Virology

   45         1090   Infection and Immunity

   46         1030   Microbiology

   47         1015   Archives of Biochemistry and Biophysics

   48         1006   Current Biology

   49          980   Developmental Biology

   50          867   Cancer Research

   51          847   Journal of Neuroscience

   52          833   Acta Crystallographica, Section D

   53          831   Yeast

   54          825   Applied and Environmental Microbiology

   55          817   FEMS Microbiology Letters

   56          749   Protein Science

   57          737   Toxicon

   58          698   Journal of Clinical Investigation

   59          698   Neuron

   60          673   Human Genetics

   61          646   American Journal of Physiology

   62          640   Nature Structural Biology

   63          638   Mechanisms of Development

   64          636   Plant and Cell Physiology

   65          600   The Journal of Experimental Medicine

   66          586   Proteins

   67          568   Journal of Medical Genetics

   68          565   Current Genetics

   69          540   Nature Cell Biology

   70          529   Molecular Endocrinology

   71          526   PLoS Genetics

   72          525   Bioscience, Biotechnology, and Biochemistry

   73          516   Journal of Neurochemistry

   74          507   The Journal of Clinical Endocrinology and Metabolism

   75          488   Endocrinology

   76          488   Mammalian Genome

   77          476   Nature Structural and Molecular Biology

   78          465   Immunogenetics

   79          459   Developmental Cell

   80          459   The FEBS Journal

   81          446   Molecular and Biochemical Parasitology

   82          438   Experimental Cell Research

   83          429   Antimicrobial Agents and Chemotherapy

   84          412   Eukaryotic Cell

   85          407   Journal of Molecular Evolution

   86          399   Peptides

   87          397   Planta

   88          396   RNA

   89          390   Molecular Biology and Evolution

   90          386   DNA and Cell Biology

   91          372   DNA Sequence

   92          357   Molecular Pharmacology

   93          351   Journal of Investigative Dermatology

   94          348   Neurology

   95          343   Comparative Biochemistry and Physiology

   96          337   Journal of the American Chemical Society

   97          336   Brain Research. Molecular Brain Research

   98          335   EMBO Reports

   99          332   Journal of Experimental Botany

  100          327   Biology of Reproduction

  101          326   The FASEB Journal

  102          325   Tissue Antigens

  103          316   Acta Crystallographica, Section F

  104          313   European Journal of Human Genetics

  105          312   Immunity

  106          311   Molecular Plant-Microbe Interactions

  107          305   The New England Journal of Medicine

  108          305   Biochimie

  109          304   Developmental Dynamics

  110          303   Genes to Cells

  111          297   American Journal of Medical Genetics. Part A

  112          295   Biological Chemistry Hoppe-Seyler

  113          295   Virus Research

  114          287   Genome Research

  115          283   PLoS Pathogens

  116          282   Cytogenetics and Cell Genetics

  117          275   Annals of Neurology

  118          269   Journal of General Microbiology

  119          269   Clinical Genetics

  120          256   BMC Genomics

  121          256   European Journal of Immunology

  122          254   Nature Communications

  123          252   Investigative Ophthalmology and Visual Science

  124          249   Nature Immunology

  125          242   Journal of Human Genetics

  126          235   Archives of Microbiology

  127          235   Applied Microbiology and Biotechnology

  128          233   Journal of Medicinal Chemistry

  129          228   DNA Research

  130          223   Journal of Cellular Biochemistry

  131          221   Glycobiology

  132          220   PLoS Biology

  133          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  134          211   Traffic

  135          210   Molecular Genetics and Metabolism

  136          206   Cell Cycle

  137          206   Circulation Research

  138          205   Archives of Virology

  139          204   Molecular and Cellular Endocrinology

  140          204   Molecular Immunology

  141          203   Diabetes

  142          201   Journal of Lipid Research

  143          198   Protein Expression and Purification

  144          193   Phytochemistry

  145          184   Nature Medicine

  146          183   Molecular Genetics and Genomics

  147          180   Insect Biochemistry and Molecular Biology

  148          178   International Journal of Cancer

  149          176   Molecular and Cellular Neuroscience

  150          173   Molecular Phylogenetics and Evolution





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1185873                 2.14                                         

   Journal                            991851     447858      1.79       1                                 

   Submitted to EMBL/GenBank/DDBJ     183466     160877      0.33       2                                 

   Submitted to other databases         7271       6733      0.01       3                                 

   Book citation                        1649       1626     <0.01       4                                 

   Plant Gene Register                   606        593     <0.01       5                                 

   Thesis                                429        426     <0.01       6                                 

   Unpublished observations              397        393     <0.01       7                                 

   Patent                                198        194     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 390274



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2459763                 4.43                                         

   ALLERGEN                              713        713     <0.01      26                                 

   ALTERNATIVE PRODUCTS                24882      24882      0.04      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        7588       7588      0.01      21                                 

   BIOTECHNOLOGY                         799        797     <0.01      25                                 

   CATALYTIC ACTIVITY                 263639     234758      0.48       5                                 

   CAUTION                             12381      12150      0.02      17                                 

   COFACTOR                           120685     110971      0.22       7                                 

   DEVELOPMENTAL STAGE                 11505      11505      0.02      19                                 

   DISEASE                              6624       4420      0.01      22                                 

   DISRUPTION PHENOTYPE                12032      12032      0.02      18                                 

   DOMAIN                              45563      39374      0.08       9                                 

   ENZYME REGULATION                   13951      13949      0.03      16                                 

   FUNCTION                           455244     436216      0.82       2                                 

   INDUCTION                           19430      19422      0.04      14                                 

   INTERACTION                         15929      15929      0.03      15                                 

   MASS SPECTROMETRY                    6415       4845      0.01      23                                 

   MISCELLANEOUS                       36621      33772      0.07      12                                 

   PATHWAY                            136673     123894      0.25       6                                 

   PHARMACEUTICAL                        101        101     <0.01      29                                 

   POLYMORPHISM                         1191       1135     <0.01      24                                 

   PTM                                 52809      39879      0.10       8                                 

   RNA EDITING                           627        627     <0.01      28                                 

   SEQUENCE CAUTION                    43757      43757      0.08      11                                 

   SIMILARITY                         503175     499036      0.91       1                                 

   SUBCELLULAR LOCATION               343947     337091      0.62       3                                 

   SUBUNIT                            270691     270478      0.49       4                                 

   TISSUE SPECIFICITY                  44135      44134      0.08      10                                 

   TOXIC DOSE                            639        590     <0.01      27                                 

   WEB RESOURCE                         8017       6801      0.01      20                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        4322653                 7.79                                         

   ACT_SITE                           160442      97362      0.29      10                                 

   BINDING                            387947     101867      0.70       2                                 

   CA_BIND                              4142       1721      0.01      36                                 

   CARBOHYD                           113880      29217      0.21      15                                 

   CHAIN                              562479     548179      1.01       1                                 

   COILED                              21755      15018      0.04      26                                 

   COMPBIAS                            58448      31382      0.11      19                                 

   CONFLICT                           133928      46842      0.24      13                                 

   CROSSLNK                            12434       6148      0.02      30                                 

   DISULFID                           120200      32575      0.22      14                                 

   DNA_BIND                            11499      10411      0.02      32                                 

   DOMAIN                             188019     115439      0.34       8                                 

   HELIX                              233822      21847      0.42       7                                 

   INIT_MET                            18610      18610      0.03      27                                 

   INTRAMEM                             2626       1122     <0.01      37                                 

   LIPID                               12794       8256      0.02      29                                 

   METAL                              365704      91259      0.66       4                                 

   MOD_RES                            241185      70817      0.43       6                                 

   MOTIF                               40819      26256      0.07      24                                 

   MUTAGEN                             62151      13925      0.11      18                                 

   NON_CONS                             2248        783     <0.01      38                                 

   NON_STD                               360        285     <0.01      39                                 

   NON_TER                             12286       9397      0.02      31                                 

   NP_BIND                            150498      83376      0.27      11                                 

   PEPTIDE                             11059       7548      0.02      33                                 

   PROPEP                              13806      11831      0.02      28                                 

   REGION                             187237      88884      0.34       9                                 

   REPEAT                             102445      14567      0.18      16                                 

   SIGNAL                              41069      41059      0.07      23                                 

   SITE                                54517      30648      0.10      21                                 

   STRAND                             243921      20581      0.44       5                                 

   TOPO_DOM                           137952      28353      0.25      12                                 

   TRANSIT                              8893       8779      0.02      34                                 

   TRANSMEM                           366596      76453      0.66       3                                 

   TURN                                56213      17702      0.10      20                                 

   UNSURE                               4383        764      0.01      35                                 

   VAR_SEQ                             51531      21746      0.09      22                                 

   VARIANT                             94530      16970      0.17      17                                 

   ZN_FING                             30225      13286      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               17794073                32.07                                                           

   Allergome                            1721       1124     <0.01     116      Protein family/group databases               

   ArachnoServer                        1147       1138     <0.01     123      Organism-specific databases                  

   Araport                             15403      15310      0.03      81      Organism-specific databases                  

   Bgee                                55136      55135      0.10      45      Gene expression databases                    

   BindingDB                            4876       4876      0.01     101      Chemistry                                    

   BioCyc                              44240      40926      0.08      52      Enzyme and pathway databases                 

   BioGrid                             48846      48378      0.09      47      Protein-protein interaction databases        

   BioMuta                             17243      17238      0.03      76      Polymorphism and mutation databases          

   BRENDA                              12824      12052      0.02      85      Enzyme and pathway databases                 

   CAZy                                 9422       8498      0.02      89      Protein family/group databases               

   CCDS                                47503      33783      0.09      49      Sequence databases                           

   CDD                                142053     134706      0.26      27      Family and domain databases                  

   CGD                                  1976       1959     <0.01     115      Organism-specific databases                  

   ChEMBL                               6215       6215      0.01      93      Chemistry                                    

   ChiTaRS                             16510      16502      0.03      79      Other                                        

   CleanEx                             30024      29394      0.05      57      Gene expression databases                    

   CollecTF                              133        133     <0.01     142      Gene expression databases                    

   COMPLUYEAST-2DPAGE                     97         97     <0.01     143      2D gel databases                             

   ConoServer                            949        866     <0.01     124      Organism-specific databases                  

   CTD                                 74240      73485      0.13      42      Organism-specific databases                  

   DEPOD                                 239        239     <0.01     139      PTM databases                                

   dictyBase                            4210       4095      0.01     105      Organism-specific databases                  

   DIP                                 17292      17236      0.03      75      Protein-protein interaction databases        

   DisGeNET                            14914      14697      0.03      82      Organism-specific databases                  

   DisProt                               699        699     <0.01     128      3D structure databases                       

   DMDM                                16367      16303      0.03      80      Polymorphism and mutation databases          

   DNASU                               18919      18848      0.03      70      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     145        145     <0.01     140      2D gel databases                             

   DrugBank                            18743       3633      0.03      71      Chemistry                                    

   EchoBASE                             4161       4161      0.01     106      Organism-specific databases                  

   EcoGene                              4294       4292      0.01     103      Organism-specific databases                  

   eggNOG                             661321     329974      1.19       5      Phylogenomic databases                       

   EMBL                               988399     543449      1.78       3      Sequence databases                           

   Ensembl                             86445      49093      0.16      40      Genome annotation databases                  

   EnsemblBacteria                    354092     335011      0.64      16      Genome annotation databases                  

   EnsemblFungi                        29367      27599      0.05      58      Genome annotation databases                  

   EnsemblMetazoa                      13983      10262      0.03      84      Genome annotation databases                  

   EnsemblPlants                       24202      19591      0.04      63      Genome annotation databases                  

   EnsemblProtists                      4998       4821      0.01     100      Genome annotation databases                  

   EPD                                 20758      20758      0.04      65      Proteomic databases                          

   ESTHER                               2480       2477     <0.01     112      Protein family/group databases               

   euHCVdb                                55         44     <0.01     145      Organism-specific databases                  

   EuPathDB                            18242      18240      0.03      73      Organism-specific databases                  

   EvolutionaryTrace                   16584      16584      0.03      78      Other                                        

   ExpressionAtlas                     37206      37206      0.07      54      Gene expression databases                    

   FlyBase                              6153       5797      0.01      94      Organism-specific databases                  

   Gene3D                             316470     258306      0.57      19      Family and domain databases                  

   GeneCards                           20333      19940      0.04      66      Organism-specific databases                  

   GeneDB                                562        506     <0.01     132      Genome annotation databases                  

   GeneID                             286962     276477      0.52      22      Genome annotation databases                  

   GeneReviews                          1156       1153     <0.01     122      Organism-specific databases                  

   GeneTree                            57998      57960      0.10      43      Phylogenomic databases                       

   Genevisible                         55175      55175      0.10      44      Gene expression databases                    

   GeneWiki                            10366      10282      0.02      88      Other                                        

   GenomeRNAi                          21947      21945      0.04      64      Other                                        

   GO                                2773352     527672      5.00       1      Ontologies                                   

   Gramene                             24202      19591      0.04      62      Genome annotation databases                  

   GuidetoPHARMACOLOGY                  1982       1982     <0.01     114      Chemistry                                    

   H-InvDB                              5588       4767      0.01      98      Organism-specific databases                  

   HAMAP                              328082     325394      0.59      17      Family and domain databases                  

   HGNC                                20140      19995      0.04      69      Organism-specific databases                  

   HOGENOM                            390211     390211      0.70      15      Phylogenomic databases                       

   HOVERGEN                            75814      75814      0.14      41      Phylogenomic databases                       

   HPA                                 27060      16797      0.05      61      Organism-specific databases                  

   IMGT_GENE-DB                          135        135     <0.01     141      Protein family/group databases               

   InParanoid                         136498     136498      0.25      29      Phylogenomic databases                       

   IntAct                              48073      48073      0.09      48      Protein-protein interaction databases        

   InterPro                          1943621     535460      3.50       2      Family and domain databases                  

   iPTMnet                             45958      45958      0.08      50      PTM databases                                

   KEGG                               503403     473823      0.91       7      Genome annotation databases                  

   KO                                 399272     398812      0.72      14      Phylogenomic databases                       

   LegioList                             765        763     <0.01     127      Organism-specific databases                  

   Leproma                               672        669     <0.01     129      Organism-specific databases                  

   MaizeGDB                              508        503     <0.01     133      Organism-specific databases                  

   MalaCards                            4234       4219      0.01     104      Organism-specific databases                  

   MaxQB                               28560      28560      0.05      60      Proteomic databases                          

   MEROPS                              11322      11322      0.02      86      Protein family/group databases               

   MGI                                 16805      16765      0.03      77      Organism-specific databases                  

   MIM                                 20331      14701      0.04      67      Organism-specific databases                  

   MINT                                31859      31859      0.06      55      Protein-protein interaction databases        

   MoonProt                               63         63     <0.01     144      Protein family/group databases               

   mycoCLAP                              356        352     <0.01     138      Protein family/group databases               

   neXtProt                            20173      20173      0.04      68      Organism-specific databases                  

   OGP                                   374        374     <0.01     137      2D gel databases                             

   OMA                                402465     402465      0.73      13      Phylogenomic databases                       

   OpenTargets                         18118      17961      0.03      74      Organism-specific databases                  

   Orphanet                             6145       3287      0.01      95      Organism-specific databases                  

   OrthoDB                            291655     291655      0.53      21      Phylogenomic databases                       

   PANTHER                            222201     209277      0.40      23      Family and domain databases                  

   PATRIC                              91573      91573      0.17      39      Genome annotation databases                  

   PaxDb                              112339     112338      0.20      34      Proteomic databases                          

   PDB                                147002      24871      0.26      26      3D structure databases                       

   PDBsum                             147002      24871      0.26      25      3D structure databases                       

   PeptideAtlas                        31805      31805      0.06      56      Proteomic databases                          

   PeroxiBase                            771        755     <0.01     126      Protein family/group databases               

   Pfam                               745215     510015      1.34       4      Family and domain databases                  

   PharmGKB                            18374      18332      0.03      72      Organism-specific databases                  

   PhosphoSitePlus                     38572      38572      0.07      53      PTM databases                                

   PhylomeDB                           95431      95431      0.17      37      Phylogenomic databases                       

   PIR                                123695     113281      0.22      32      Sequence databases                           

   PIRSF                              105370     104369      0.19      36      Family and domain databases                  

   PMAP-CutDB                           1461       1461     <0.01     117      Other                                        

   PomBase                              5133       5129      0.01      99      Organism-specific databases                  

   PRIDE                              141646     141646      0.26      28      Proteomic databases                          

   PRINTS                             133469     117935      0.24      31      Family and domain databases                  

   PRO                                 94617      94617      0.17      38      Other                                        

   ProDom                              29242      29059      0.05      59      Family and domain databases                  

   ProMEX                                449        449     <0.01     135      Proteomic databases                          

   PROSITE                            458298     294271      0.83      10      Family and domain databases                  

   ProteinModelPortal                 447213     447213      0.81      11      3D structure databases                       

   Proteomes                          475391     453053      0.86       9      Other                                        

   PseudoCAP                            1318       1309     <0.01     118      Organism-specific databases                  

   Reactome                           116498      35293      0.21      33      Enzyme and pathway databases                 

   REBASE                                407        407     <0.01     136      Protein family/group databases               

   RefSeq                             611268     465940      1.10       6      Sequence databases                           

   REPRODUCTION-2DPAGE                  1258       1037     <0.01     119      2D gel databases                             

   RGD                                  7915       7914      0.01      90      Organism-specific databases                  

   SABIO-RK                             3547       3547      0.01     107      Enzyme and pathway databases                 

   SFLD                                11138       6431      0.02      87      Family and domain databases                  

   SGD                                  6739       6734      0.01      91      Organism-specific databases                  

   SignaLink                            3020       3020      0.01     110      Enzyme and pathway databases                 

   SIGNOR                               3462       3462      0.01     108      Enzyme and pathway databases                 

   SMART                              190753     140810      0.34      24      Family and domain databases                  

   SMR                                429968     429968      0.77      12      3D structure databases                       

   STRING                             327838     327836      0.59      18      Protein-protein interaction databases        

   SUPFAM                             488521     371088      0.88       8      Family and domain databases                  

   SWISS-2DPAGE                         1178       1178     <0.01     121      2D gel databases                             

   SwissLipids                          1187       1104     <0.01     120      Chemistry                                    

   SwissPalm                            5947       5947      0.01      96      PTM databases                                

   TAIR                                14219      14164      0.03      83      Organism-specific databases                  

   TCDB                                 6381       6346      0.01      92      Protein family/group databases               

   TIGRFAMs                           291741     271752      0.53      20      Family and domain databases                  

   TopDownProteomics                    3248       2968      0.01     109      Proteomic databases                          

   TreeFam                             45106      45098      0.08      51      Phylogenomic databases                       

   TubercuList                          2184       2148     <0.01     113      Organism-specific databases                  

   UCD-2DPAGE                            497        497     <0.01     134      2D gel databases                             

   UCSC                                49498      45276      0.09      46      Genome annotation databases                  

   UniCarbKB                             584        584     <0.01     131      PTM databases                                

   UniGene                            108052      95329      0.19      35      Sequence databases                           

   UniPathway                         135949     123183      0.25      30      Enzyme and pathway databases                 

   VectorBase                            670        592     <0.01     130      Genome annotation databases                  

   WBParaSite                             32         32     <0.01     146      Genome annotation databases                  

   World-2DPAGE                          928        917     <0.01     125      2D gel databases                             

   WormBase                             5811       4461      0.01      97      Organism-specific databases                  

   Xenbase                              4502       4496      0.01     102      Organism-specific databases                  

   ZFIN                                 2849       2849      0.01     111      Organism-specific databases                  



Total number of cross-referenced databases: 146



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.26   Gln (Q) 3.93   Leu (L) 9.65   Ser (S) 6.61

   Arg (R) 5.53   Glu (E) 6.74   Lys (K) 5.82   Thr (T) 5.35

   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.41   Trp (W) 1.09

   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92

   Cys (C) 1.37   Ile (I) 5.93   Pro (P) 4.72   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3853 are encoded on a plasmid.



12188 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11623 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 78577