To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https



         UniProtKB/Swiss-Prot protein knowledgebase release 2017_11 statistics





1.  INTRODUCTION



Release 2017_11 of 22-Nov-17 of UniProtKB/Swiss-Prot contains 556196 sequence entries,

comprising 199341870 amino acids abstracted from 256751 references. 



195 sequences have been added since release 2017_10, the sequence data of

13 existing entries has been updated and the annotations of

188287 entries have been revised.



Number of fragments: 9131

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 39790





Protein existence (PE):           entries     %



1: Evidence at protein level        97542   17.5%

2: Evidence at transcript level     57085   10.3%

3: Inferred from homology          386028   69.4%

4: Predicted                        13675    2.5%

5: Uncertain                         1866    0.3%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 13553



   The first twenty species represent 119842 sequences:  21.5 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5637

                            2x: 1934

                            3x: 1046

                            4x:  685

                            5x:  501

                            6x:  404

                            7x:  290

                            8x:  245

                            9x:  231

                           10x:  135

                       11- 20x:  733

                       21- 50x:  445

                       51-100x:  218

                         >100x: 1049





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20243  Homo sapiens (Human)

       2      16944  Mus musculus (Mouse)

       3      15591  Arabidopsis thaliana (Mouse-ear cress)

       4       8017  Rattus norvegicus (Rat)

       5       6721  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       5999  Bos taurus (Bovine)

       7       5141  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4436  Escherichia coli (strain K12)

       9       4185  Bacillus subtilis (strain 168)

      10       4136  Dictyostelium discoideum (Slime mold)

      11       3972  Caenorhabditis elegans

      12       3908  Oryza sativa subsp. japonica (Rice)

      13       3487  Drosophila melanogaster (Fruit fly)

      14       3425  Xenopus laevis (African clawed frog)

      15       3031  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2287  Gallus gallus (Chicken)

      17       2219  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      18       2167  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

      19       2035  Escherichia coli O157:H7

      20       1898  Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

      21       1795  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1787  Methanocaldococcus jannaschii  

      23       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      24       1706  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      25       1694  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      26       1681  Shigella flexneri

      27       1421  Sus scrofa (Pig)

      28       1347  Salmonella typhi

      29       1321  Pseudomonas aeruginosa 

      30       1244  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      31       1172  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      32       1063  Synechocystis sp. (strain PCC 6803 / Kazusa)

      33       1029  Archaeoglobus fulgidus 

      34       1022  Yersinia pestis

      35       1005  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      36        975  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      37        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      38        930  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      39        927  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      40        926  Staphylococcus aureus (strain N315)

      41        910  Kluyveromyces lactis   

      42        909  Acanthamoeba polyphaga mimivirus (APMV)

      43        899  Staphylococcus aureus (strain COL)

      44        895  Staphylococcus aureus (strain MW2)

      45        893  Oryctolagus cuniculus (Rabbit)

      46        892  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      47        889  Staphylococcus aureus (strain MSSA476)

      48        888  Staphylococcus aureus (strain MRSA252)

      49        882  Salmonella choleraesuis (strain SC-B67)

      50        879  Shigella sonnei (strain Ss046)

      51        878  Emericella nidulans  

      52        878  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      53        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      54        862  Candida glabrata   

      55        854  Neurospora crassa 

      56        841  Escherichia coli O9:H4 (strain HS)

      57        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      58        829  Shigella boydii serotype 4 (strain Sb227)

      59        825  Escherichia coli (strain UTI89 / UPEC)

      60        822  Shigella dysenteriae serotype 1 (strain Sd197)

      61        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      62        817  Canis lupus familiaris (Dog) (Canis familiaris)

      63        815  Oryza sativa subsp. indica (Rice)

      64        803  Zea mays (Maize)

      65        796  Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 

      66        793  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      67        791  Escherichia coli (strain SMS-3-5 / SECEC)

      68        784  Aquifex aeolicus (strain VF5)

      69        776  Pasteurella multocida (strain Pm70)

      70        774  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      71        771  Escherichia coli (strain K12 / DH10B)

      72        771  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      73        769  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

      74        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      75        765  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      76        762  Escherichia coli (strain 55989 / EAEC)

      77        761  Escherichia coli O8 (strain IAI1)

      78        760  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      79        760  Shigella flexneri serotype 5b (strain 8401)

      80        759  Staphylococcus epidermidis (strain ATCC 12228)

      81        758  Staphylococcus aureus (strain NCTC 8325)

      82        756  Escherichia coli O45:K1 (strain S88 / ExPEC)

      83        756  Escherichia coli (strain SE11)

      84        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      85        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      86        745  Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

      87        741  Bacillus halodurans 

      88        741  Bacillus anthracis

      89        737  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      90        733  Vibrio vulnificus (strain CMCP6)

      91        731  Escherichia coli O81 (strain ED1a)

      92        722  Salmonella enteritidis PT4 (strain P125109)

      93        718  Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

      94        718  Vibrio vulnificus (strain YJ016)

      95        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      96        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      97        715  Enterobacter sp. (strain 638)

      98        714  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

      99        714  Salmonella paratyphi A (strain AKU_12601)

     100        714  Escherichia coli O1:K1 / APEC

     101        713  Salmonella newport (strain SL254)

     102        713  Salmonella agona (strain SL483)

     103        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     104        712  Salmonella schwarzengrund (strain CVM19633)

     105        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     106        710  Salmonella heidelberg (strain SL476)

     107        702  Salmonella dublin (strain CT_02021853)

     108        698  Klebsiella pneumoniae (strain 342)

     109        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     110        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     111        693  Pan troglodytes (Chimpanzee)

     112        692  Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

     113        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     114        684  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     115        679  Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

     116        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     117        673  Staphylococcus aureus (strain USA300)

     118        671  Escherichia coli

     119        670  Serratia proteamaculans (strain 568)

     120        669  Mycobacterium leprae (strain TN)

     121        667  Yersinia pestis (strain Pestoides F)

     122        665  Bacillus cereus 

     123        662  Bradyrhizobium diazoefficiens 

     124        658  Sinorhizobium fredii (strain NBRC 101917 / NGR234)

     125        653  Debaryomyces hansenii   

     126        650  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     127        645  Shewanella oneidensis (strain MR-1)

     128        645  Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 

     129        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     130        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     131        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     132        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     133        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     134        620  Methanothermobacter thermautotrophicus  

     135        620  Treponema pallidum (strain Nichols)

     136        613  Staphylococcus haemolyticus (strain JCSC1435)

     137        610  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)

     138        610  Xanthomonas campestris pv. campestris 

     139        607  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     140        603  Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)

     141        603  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     142        602  Photobacterium profundum (strain SS9)

     143        602  Staphylococcus saprophyticus subsp. saprophyticus 

     144        601  Salmonella paratyphi C (strain RKS4594)

     145        600  Yersinia pestis bv. Antiqua (strain Angola)

     146        594  Bacillus cereus (strain ATCC 10987 / NRS 248)

     147        594  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     148        593  Pseudomonas aeruginosa (strain UCBPP-PA14)

     149        591  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     150        586  Rickettsia prowazekii (strain Madrid E)

     151        582  Neisseria meningitidis serogroup B (strain MC58)

     152        579  Brucella suis biovar 1 (strain 1330)

     153        577  Caenorhabditis briggsae

     154        574  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     155        573  Vibrio fischeri (strain ATCC 700601 / ES114)

     156        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     157        571  Caulobacter crescentus (strain ATCC 19089 / CB15)

     158        569  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     159        568  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     160        567  Pseudomonas syringae pv. syringae (strain B728a)

     161        564  Bacillus licheniformis 

     162        562  Bacillus cereus (strain ZK / E33L)

     163        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     164        559  Clostridium acetobutylicum 

     165        556  Xanthomonas axonopodis pv. citri (strain 306)

     166        554  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

     167        553  Oceanobacillus iheyensis 

     168        552  Pseudomonas fluorescens (strain Pf0-1)

     169        550  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     170        549  Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

     171        547  Pseudomonas savastanoi pv. phaseolicola  (Pseudomonas syringae pv. phaseolicola 

     172        547  Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

     173        536  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     174        531  Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

     175        529  Sodalis glossinidius (strain morsitans)

     176        529  Listeria monocytogenes serotype 4b (strain F2365)

     177        527  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     178        526  Corynebacterium glutamicum 

     179        522  Xylella fastidiosa (strain 9a5c)

     180        518  Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

     181        517  Chromobacterium violaceum 

     182        516  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     183        515  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     184        513  Deinococcus radiodurans 

     185        512  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     186        512  Pseudomonas aeruginosa (strain PA7)

     187        511  Staphylococcus aureus (strain Newman)

     188        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     189        510  Geobacillus kaustophilus (strain HTA426)

     190        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     191        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     192        507  Streptomyces avermitilis 

     193        502  Pseudomonas entomophila (strain L48)

     194        501  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     195        501  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     196        499  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     197        499  Brucella abortus biovar 1 (strain 9-941)

     198        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     199        497  Haemophilus influenzae (strain 86-028NP)

     200        496  Bacillus clausii (strain KSM-K16)

     201        496  Burkholderia pseudomallei (strain K96243)

     202        494  Proteus mirabilis (strain HI4320)

     203        493  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     204        493  Xanthomonas campestris pv. campestris (strain 8004)

     205        492  Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) 

     206        491  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     207        490  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     208        487  Shewanella sp. (strain MR-7)

     209        487  Methanosarcina mazei  

     210        486  Mannheimia succiniciproducens (strain MBEL55E)

     211        485  Thermosynechococcus elongatus (strain BP-1)

     212        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     213        484  Shewanella sp. (strain MR-4)

     214        484  Pyrococcus horikoshii 

     215        484  Pseudomonas aeruginosa (strain LESB58)

     216        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     217        483  Brucella abortus (strain 2308)

     218        479  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)

     219        479  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     220        478  Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

     221        477  Pyrococcus abyssi (strain GE5 / Orsay)

     222        475  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     223        475  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 

     224        474  Burkholderia lata 

     225        472  Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

     226        471  Nicotiana tabacum (Common tobacco)

     227        471  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     228        468  Clostridium perfringens (strain 13 / Type A)

     229        466  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     230        466  Shewanella frigidimarina (strain NCIMB 400)

     231        466  Shewanella sp. (strain ANA-3)

     232        466  Pseudomonas putida (strain GB-1)

     233        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     234        465  Anabaena variabilis (strain ATCC 29413 / PCC 7937)

     235        464  Aeromonas hydrophila subsp. hydrophila 

     236        463  Enterococcus faecalis (strain ATCC 700802 / V583)

     237        462  Burkholderia mallei (strain ATCC 23344)

     238        461  Campylobacter jejuni subsp. jejuni serotype O:2 

     239        459  Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha 

     240        458  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     241        457  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     242        457  Ovis aries (Sheep)

     243        455  Staphylococcus aureus (strain JH1)

     244        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     245        453  Pseudomonas putida (strain W619)

     246        452  Shewanella baltica (strain OS185)

     247        452  Aeromonas salmonicida (strain A449)

     248        452  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

     249        450  Caldanaerobacter subterraneus subsp. tengcongensis  

     250        450  Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19483 (  4%)

    Bacteria         333309 ( 60%)

    Eukaryota        186651 ( 34%)

    Viruses           16753 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20244 ( 11%)           (  4%)

     Other Mammalia         46565 ( 25%)           (  8%)

     Other Vertebrata       18196 ( 10%)           (  3%)

     Viridiplantae          39267 ( 21%)           (  7%)

     Fungi                  32964 ( 18%)           (  6%)

     Insecta                 9109 (  5%)           (  2%)

     Nematoda                4868 (  3%)           (  1%)

     Other                  15438 (  8%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9394             1001-1100     3957

                 51- 100   42366             1101-1200     2785

                101- 150   58790             1201-1300     2130

                151- 200   58742             1301-1400     1978

                201- 250   57603             1401-1500     1593

                251- 300   51265             1501-1600      777

                301- 350   51621             1601-1700      605

                351- 400   44793             1701-1800      525

                401- 450   36819             1801-1900      463

                451- 500   29636             1901-2000      373

                501- 550   21326             2001-2100      243

                551- 600   15240             2101-2200      318

                601- 650   12726             2201-2300      309

                651- 700    9180             2301-2400      202

                701- 750    7611             2401-2500      156

                751- 800    5471             >2500         1238

                801- 850    4741

                851- 900    5185

                901- 950    4018

                951-1000    2886



   





   The average sequence length in UniProtKB/Swiss-Prot is 358 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2696





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  853

                       2x:  379

                       3x:  169

                       4x:  131

                       5x:  105

                       6x:   91

                       7x:   67

                       8x:   51

                       9x:   45

                      10x:   29

                  11- 20x:  212

                  21- 50x:  220

                  51-100x:  117

                    >100x:  227





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        24053   Journal of Biological Chemistry

    2        11076   Proceedings of the National Academy of Sciences of the U.S.A.

    3         6483   Journal of Bacteriology

    4         5532   Biochemical and Biophysical Research Communications

    5         5188   Biochemistry

    6         4939   Nucleic Acids Research

    7         4792   Gene

    8         4763   FEBS Letters

    9         4619   The EMBO Journal

   10         4367   Nature

   11         4289   Molecular and Cellular Biology

   12         4177   Journal of Molecular Biology

   13         3572   Biochimica et Biophysica Acta

   14         3487   Cell

   15         3372   European Journal of Biochemistry

   16         3052   Journal of Virology

   17         2930   Science

   18         2804   Biochemical Journal

   19         2531   Genomics

   20         2479   Plant Physiology

   21         2431   Molecular Microbiology

   22         2145   Journal of Cell Biology

   23         2068   The American Journal of Human Genetics

   24         1913   The Plant Cell

   25         1832   Plant Molecular Biology

   26         1801   Genes and Development

   27         1768   Human Molecular Genetics

   28         1760   The Plant Journal

   29         1716   PLoS ONE

   30         1716   Nature Genetics

   31         1715   Virology

   32         1627   Development

   33         1622   Molecular Biology of the Cell

   34         1538   Human Mutation

   35         1530   Oncogene

   36         1474   Molecular Cell

   37         1392   Journal of Immunology

   38         1391   Molecular and General Genetics

   39         1327   Journal of Biochemistry

   40         1292   Structure

   41         1285   Genetics

   42         1204   Journal of Cell Science

   43         1125   Blood

   44         1103   Journal of General Virology

   45         1093   Infection and Immunity

   46         1033   Microbiology

   47         1025   Archives of Biochemistry and Biophysics

   48         1017   Current Biology

   49         1002   Developmental Biology

   50          875   Cancer Research

   51          869   Journal of Neuroscience

   52          858   Applied and Environmental Microbiology

   53          847   Acta Crystallographica, Section D

   54          831   Yeast

   55          824   FEMS Microbiology Letters

   56          756   Protein Science

   57          752   Toxicon

   58          721   Neuron

   59          706   Journal of Clinical Investigation

   60          680   Human Genetics

   61          662   American Journal of Physiology

   62          653   Plant and Cell Physiology

   63          642   Nature Structural Biology

   64          640   Mechanisms of Development

   65          614   The Journal of Experimental Medicine

   66          602   Proteins

   67          583   Journal of Medical Genetics

   68          565   Current Genetics

   69          564   PLoS Genetics

   70          553   Nature Cell Biology

   71          532   Molecular Endocrinology

   72          531   Bioscience, Biotechnology, and Biochemistry

   73          523   Journal of Neurochemistry

   74          512   The Journal of Clinical Endocrinology and Metabolism

   75          497   Nature Structural and Molecular Biology

   76          494   Endocrinology

   77          488   Mammalian Genome

   78          483   Developmental Cell

   79          472   The FEBS Journal

   80          469   Immunogenetics

   81          447   Molecular and Biochemical Parasitology

   82          444   Experimental Cell Research

   83          432   Antimicrobial Agents and Chemotherapy

   84          416   Eukaryotic Cell

   85          410   Planta

   86          407   Journal of Molecular Evolution

   87          403   Peptides

   88          402   RNA

   89          395   Molecular Biology and Evolution

   90          386   DNA and Cell Biology

   91          372   DNA Sequence

   92          365   Molecular Pharmacology

   93          354   Journal of Investigative Dermatology

   94          352   Neurology

   95          352   Journal of Experimental Botany

   96          349   Journal of the American Chemical Society

   97          345   Comparative Biochemistry and Physiology

   98          343   EMBO Reports

   99          339   Brain Research. Molecular Brain Research

  100          337   Biology of Reproduction

  101          335   The FASEB Journal

  102          331   Acta Crystallographica, Section F

  103          325   Tissue Antigens

  104          320   European Journal of Human Genetics

  105          319   Molecular Plant-Microbe Interactions

  106          317   American Journal of Medical Genetics. Part A

  107          314   Immunity

  108          308   The New England Journal of Medicine

  109          308   Biochimie

  110          306   Developmental Dynamics

  111          305   Nature Communications

  112          304   Genes to Cells

  113          298   Virus Research

  114          295   Biological Chemistry Hoppe-Seyler

  115          295   PLoS Pathogens

  116          292   Genome Research

  117          282   Cytogenetics and Cell Genetics

  118          281   Clinical Genetics

  119          276   Annals of Neurology

  120          269   Journal of General Microbiology

  121          265   European Journal of Immunology

  122          261   Investigative Ophthalmology and Visual Science

  123          260   BMC Genomics

  124          258   Nature Immunology

  125          248   Journal of Human Genetics

  126          242   Applied Microbiology and Biotechnology

  127          241   Journal of Medicinal Chemistry

  128          236   Archives of Microbiology

  129          228   DNA Research

  130          227   Glycobiology

  131          226   Journal of Cellular Biochemistry

  132          226   PLoS Biology

  133          221   Traffic

  134          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  135          215   Molecular Genetics and Metabolism

  136          212   Circulation Research

  137          211   Cell Cycle

  138          209   Journal of Lipid Research

  139          206   Diabetes

  140          205   Molecular and Cellular Endocrinology

  141          205   Archives of Virology

  142          204   Molecular Immunology

  143          203   Scientific Reports

  144          199   Protein Expression and Purification

  145          197   Phytochemistry

  146          187   Nature Medicine

  147          185   Molecular Genetics and Genomics

  148          181   Insect Biochemistry and Molecular Biology

  149          180   Molecular and Cellular Neuroscience

  150          179   International Journal of Cancer





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1198399                 2.15                                         

   Journal                           1004662     450136      1.81       1                                 

   Submitted to EMBL/GenBank/DDBJ     183116     160335      0.33       2                                 

   Submitted to other databases         7324       6777      0.01       3                                 

   Book citation                        1652       1629     <0.01       4                                 

   Plant Gene Register                   611        598     <0.01       5                                 

   Thesis                                432        429     <0.01       6                                 

   Unpublished observations              397        393     <0.01       7                                 

   Patent                                199        195     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 396462



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2482189                 4.46                                         

   ALLERGEN                              715        715     <0.01      26                                 

   ALTERNATIVE PRODUCTS                25038      25038      0.05      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        7834       7834      0.01      20                                 

   BIOTECHNOLOGY                         821        819     <0.01      25                                 

   CATALYTIC ACTIVITY                 264895     234867      0.48       5                                 

   CAUTION                             12583      12350      0.02      18                                 

   COFACTOR                           121798     111776      0.22       7                                 

   DEVELOPMENTAL STAGE                 11708      11707      0.02      19                                 

   DISEASE                              6771       4520      0.01      22                                 

   DISRUPTION PHENOTYPE                12746      12746      0.02      17                                 

   DOMAIN                              46942      40513      0.08       9                                 

   ENZYME REGULATION                   14133      14131      0.03      16                                 

   FUNCTION                           459689     440086      0.83       2                                 

   INDUCTION                           19852      19844      0.04      14                                 

   INTERACTION                         19011      19011      0.03      15                                 

   MASS SPECTROMETRY                    6595       4995      0.01      23                                 

   MISCELLANEOUS                       37924      35088      0.07      12                                 

   PATHWAY                            137354     124570      0.25       6                                 

   PHARMACEUTICAL                        104        104     <0.01      29                                 

   POLYMORPHISM                         1199       1143     <0.01      24                                 

   PTM                                 54121      40523      0.10       8                                 

   RNA EDITING                           627        627     <0.01      28                                 

   SEQUENCE CAUTION                    43931      43931      0.08      11                                 

   SIMILARITY                         504529     500384      0.91       1                                 

   SUBCELLULAR LOCATION               345588     338559      0.62       3                                 

   SUBUNIT                            273328     273073      0.49       4                                 

   TISSUE SPECIFICITY                  44789      44788      0.08      10                                 

   TOXIC DOSE                            651        600     <0.01      27                                 

   WEB RESOURCE                         6913       5754      0.01      21                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        4391539                 7.90                                         

   ACT_SITE                           161970      98112      0.29      10                                 

   BINDING                            395584     104263      0.71       2                                 

   CA_BIND                              4163       1725      0.01      36                                 

   CARBOHYD                           114930      29446      0.21      15                                 

   CHAIN                              563837     549375      1.01       1                                 

   COILED                              21929      15151      0.04      27                                 

   COMPBIAS                            58672      31530      0.11      19                                 

   CONFLICT                           134375      47024      0.24      13                                 

   CROSSLNK                            23207       8297      0.04      26                                 

   DISULFID                           121864      32939      0.22      14                                 

   DNA_BIND                            11549      10454      0.02      32                                 

   DOMAIN                             189931     116838      0.34       9                                 

   HELIX                              240007      22354      0.43       7                                 

   INIT_MET                            16992      16992      0.03      28                                 

   INTRAMEM                             2610       1169     <0.01      37                                 

   LIPID                               12874       8311      0.02      30                                 

   METAL                              373060      93124      0.67       3                                 

   MOD_RES                            246721      71082      0.44       6                                 

   MOTIF                               41795      27402      0.08      23                                 

   MUTAGEN                             64663      14386      0.12      18                                 

   NON_CONS                             2248        783     <0.01      38                                 

   NON_STD                               360        285     <0.01      39                                 

   NON_TER                             12280       9394      0.02      31                                 

   NP_BIND                            154190      84199      0.28      11                                 

   PEPTIDE                             11234       7706      0.02      33                                 

   PROPEP                              13878      11891      0.02      29                                 

   REGION                             190477      91021      0.34       8                                 

   REPEAT                             103278      14654      0.19      16                                 

   SIGNAL                              41210      41200      0.07      24                                 

   SITE                                55416      30933      0.10      21                                 

   STRAND                             250527      21060      0.45       5                                 

   TOPO_DOM                           138818      28488      0.25      12                                 

   TRANSIT                              9019       8903      0.02      34                                 

   TRANSMEM                           368258      76791      0.66       4                                 

   TURN                                57755      18121      0.10      20                                 

   UNSURE                               4428        787      0.01      35                                 

   VAR_SEQ                             51733      21866      0.09      22                                 

   VARIANT                             95405      17011      0.17      17                                 

   ZN_FING                             30292      13328      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               18316931                32.93                                                           

   Allergome                            1732       1130     <0.01     118      Protein family/group databases               

   ArachnoServer                        1149       1140     <0.01     125      Organism-specific databases                  

   Araport                             15611      15517      0.03      82      Organism-specific databases                  

   Bgee                                56005      56004      0.10      44      Gene expression databases                    

   BindingDB                            4901       4901      0.01     102      Chemistry                                    

   BioCyc                              44377      41064      0.08      52      Enzyme and pathway databases                 

   BioGrid                             49636      49158      0.09      48      Protein-protein interaction databases        

   BioMuta                             17242      17237      0.03      76      Polymorphism and mutation databases          

   BRENDA                              12851      12079      0.02      86      Enzyme and pathway databases                 

   CAZy                                 9441       8515      0.02      89      Protein family/group databases               

   CCDS                                47572      33856      0.09      50      Sequence databases                           

   CDD                                177497     163091      0.32      25      Family and domain databases                  

   CGD                                  1978       1961     <0.01     116      Organism-specific databases                  

   ChEMBL                               6523       6523      0.01      92      Chemistry                                    

   ChiTaRS                             16522      16514      0.03      79      Other                                        

   CleanEx                             30023      29393      0.05      58      Gene expression databases                    

   CollecTF                              133        133     <0.01     144      Gene expression databases                    

   COMPLUYEAST-2DPAGE                     97         97     <0.01     145      2D gel databases                             

   ConoServer                            949        866     <0.01     126      Organism-specific databases                  

   CORUM                                5168       5168      0.01      99      Protein-protein interaction databases        

   CTD                                 74537      73673      0.13      42      Organism-specific databases                  

   DEPOD                                 239        239     <0.01     141      PTM databases                                

   dictyBase                            4210       4095      0.01     105      Organism-specific databases                  

   DIP                                 17326      17294      0.03      75      Protein-protein interaction databases        

   DisGeNET                            14856      14619      0.03      83      Organism-specific databases                  

   DisProt                               707        702     <0.01     130      3D structure databases                       

   DMDM                                16365      16301      0.03      80      Polymorphism and mutation databases          

   DNASU                               18944      18873      0.03      71      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     145        145     <0.01     142      2D gel databases                             

   DrugBank                            18749       3637      0.03      72      Chemistry                                    

   EchoBASE                             4159       4159      0.01     107      Organism-specific databases                  

   EcoGene                              4293       4291      0.01     104      Organism-specific databases                  

   eggNOG                             662709     330661      1.19       5      Phylogenomic databases                       

   ELM                                  1808       1808     <0.01     117      Protein-protein interaction databases        

   EMBL                               986673     544634      1.77       3      Sequence databases                           

   Ensembl                             87697      49493      0.16      40      Genome annotation databases                  

   EnsemblBacteria                    355045     335954      0.64      16      Genome annotation databases                  

   EnsemblFungi                        28216      26727      0.05      61      Genome annotation databases                  

   EnsemblMetazoa                      15793      10544      0.03      81      Genome annotation databases                  

   EnsemblPlants                       27976      20731      0.05      63      Genome annotation databases                  

   EnsemblProtists                      4956       4780      0.01     101      Genome annotation databases                  

   EPD                                 20285      20285      0.04      67      Proteomic databases                          

   ESTHER                               2482       2480     <0.01     113      Protein family/group databases               

   euHCVdb                                55         44     <0.01     147      Organism-specific databases                  

   EuPathDB                            37427      37247      0.07      55      Organism-specific databases                  

   EvolutionaryTrace                   16604      16604      0.03      78      Other                                        

   ExpressionAtlas                     40013      40013      0.07      53      Gene expression databases                    

   FlyBase                              6173       5818      0.01      94      Organism-specific databases                  

   Gene3D                             342941     278011      0.62      17      Family and domain databases                  

   GeneCards                           20194      20025      0.04      69      Organism-specific databases                  

   GeneDB                                567        511     <0.01     134      Genome annotation databases                  

   GeneID                             292004     281330      0.53      22      Genome annotation databases                  

   GeneReviews                          1155       1152     <0.01     124      Organism-specific databases                  

   GeneTree                            58320      58287      0.10      43      Phylogenomic databases                       

   Genevisible                         55199      55199      0.10      45      Gene expression databases                    

   GeneWiki                            10366      10282      0.02      88      Other                                        

   GenomeRNAi                          21971      21969      0.04      65      Other                                        

   GO                                2850632     529633      5.13       1      Ontologies                                   

   Gramene                             28093      20808      0.05      62      Genome annotation databases                  

   GuidetoPHARMACOLOGY                  2004       2004     <0.01     115      Chemistry                                    

   H-InvDB                              5588       4767      0.01      98      Organism-specific databases                  

   HAMAP                              328694     326066      0.59      19      Family and domain databases                  

   HGNC                                20174      20032      0.04      70      Organism-specific databases                  

   HOGENOM                            390690     390690      0.70      15      Phylogenomic databases                       

   HOVERGEN                            75892      75892      0.14      41      Phylogenomic databases                       

   HPA                                 27056      16797      0.05      64      Organism-specific databases                  

   IMGT_GENE-DB                          141        141     <0.01     143      Protein family/group databases               

   InParanoid                         136655     136655      0.25      29      Phylogenomic databases                       

   IntAct                              50772      50772      0.09      47      Protein-protein interaction databases        

   InterPro                          2182729     537256      3.92       2      Family and domain databases                  

   iPTMnet                             51212      51212      0.09      46      PTM databases                                

   KEGG                               503552     475133      0.91       7      Genome annotation databases                  

   KO                                 402189     401743      0.72      14      Phylogenomic databases                       

   LegioList                             765        763     <0.01     129      Organism-specific databases                  

   Leproma                               672        669     <0.01     132      Organism-specific databases                  

   MaizeGDB                              509        505     <0.01     135      Organism-specific databases                  

   MalaCards                            4165       4163      0.01     106      Organism-specific databases                  

   MaxQB                               29724      29724      0.05      59      Proteomic databases                          

   MEROPS                              11358      11358      0.02      87      Protein family/group databases               

   MGI                                 16848      16808      0.03      77      Organism-specific databases                  

   MIM                                 20616      14857      0.04      66      Organism-specific databases                  

   MINT                                31884      31884      0.06      56      Protein-protein interaction databases        

   MoonProt                               63         63     <0.01     146      Protein family/group databases               

   mycoCLAP                              359        354     <0.01     140      Protein family/group databases               

   neXtProt                            20196      20196      0.04      68      Organism-specific databases                  

   OGP                                   374        374     <0.01     139      2D gel databases                             

   OMA                                403185     403185      0.72      13      Phylogenomic databases                       

   OpenTargets                         18144      17990      0.03      74      Organism-specific databases                  

   Orphanet                             6144       3286      0.01      95      Organism-specific databases                  

   OrthoDB                            292382     292382      0.53      21      Phylogenomic databases                       

   PANTHER                            240806     229319      0.43      23      Family and domain databases                  

   PATRIC                              91669      91669      0.16      39      Genome annotation databases                  

   PaxDb                              112554     112554      0.20      34      Proteomic databases                          

   PDB                                154024      25659      0.28      26      3D structure databases                       

   PDBsum                             154024      25659      0.28      27      3D structure databases                       

   PeptideAtlas                        31868      31868      0.06      57      Proteomic databases                          

   PeroxiBase                            772        756     <0.01     128      Protein family/group databases               

   Pfam                               754399     513545      1.36       4      Family and domain databases                  

   PharmGKB                            18373      18331      0.03      73      Organism-specific databases                  

   PhosphoSitePlus                     39005      39005      0.07      54      PTM databases                                

   PhylomeDB                           95494      95494      0.17      37      Phylogenomic databases                       

   PIR                                123905     113475      0.22      32      Sequence databases                           

   PIRSF                              108596     107568      0.20      36      Family and domain databases                  

   PMAP-CutDB                           1461       1461     <0.01     119      Other                                        

   PomBase                              5133       5129      0.01     100      Organism-specific databases                  

   PRIDE                              141684     141684      0.25      28      Proteomic databases                          

   PRINTS                             133261     117721      0.24      31      Family and domain databases                  

   PRO                                 95146      95146      0.17      38      Other                                        

   ProDom                              29253      29070      0.05      60      Family and domain databases                  

   ProMEX                                453        453     <0.01     137      Proteomic databases                          

   PROSITE                            461329     295925      0.83      10      Family and domain databases                  

   ProteinModelPortal                 447563     447563      0.80      11      3D structure databases                       

   Proteomes                          475752     453569      0.86       9      Other                                        

   PseudoCAP                            1329       1320     <0.01     120      Organism-specific databases                  

   Reactome                           117024      34983      0.21      33      Enzyme and pathway databases                 

   REBASE                                403        403     <0.01     138      Protein family/group databases               

   RefSeq                             609678     465222      1.10       6      Sequence databases                           

   REPRODUCTION-2DPAGE                  1259       1038     <0.01     122      2D gel databases                             

   RGD                                  7941       7940      0.01      90      Organism-specific databases                  

   SABIO-RK                             3649       3649      0.01     109      Enzyme and pathway databases                 

   SFLD                                14105       6486      0.03      85      Family and domain databases                  

   SGD                                  6739       6734      0.01      91      Organism-specific databases                  

   SignaLink                            3025       3025      0.01     111      Enzyme and pathway databases                 

   SIGNOR                               3899       3899      0.01     108      Enzyme and pathway databases                 

   SMART                              191239     141155      0.34      24      Family and domain databases                  

   SMR                                437694     437694      0.79      12      3D structure databases                       

   STRING                             331718     331718      0.60      18      Protein-protein interaction databases        

   SUPFAM                             503264     378533      0.90       8      Family and domain databases                  

   SWISS-2DPAGE                         1178       1178     <0.01     123      2D gel databases                             

   SwissLipids                          1277       1192     <0.01     121      Chemistry                                    

   SwissPalm                            5947       5947      0.01      96      PTM databases                                

   TAIR                                14416      14361      0.03      84      Organism-specific databases                  

   TCDB                                 6486       6451      0.01      93      Protein family/group databases               

   TIGRFAMs                           292526     272519      0.53      20      Family and domain databases                  

   TopDownProteomics                    3248       2968      0.01     110      Proteomic databases                          

   TreeFam                             45198      45190      0.08      51      Phylogenomic databases                       

   TubercuList                          2185       2149     <0.01     114      Organism-specific databases                  

   UCD-2DPAGE                            497        497     <0.01     136      2D gel databases                             

   UCSC                                49625      45388      0.09      49      Genome annotation databases                  

   UniCarbKB                             584        584     <0.01     133      PTM databases                                

   UniGene                            109091      95870      0.20      35      Sequence databases                           

   UniPathway                         136122     123351      0.24      30      Enzyme and pathway databases                 

   VectorBase                            675        588     <0.01     131      Genome annotation databases                  

   WBParaSite                             34         34     <0.01     148      Genome annotation databases                  

   World-2DPAGE                          929        918     <0.01     127      2D gel databases                             

   WormBase                             5908       4527      0.01      97      Organism-specific databases                  

   Xenbase                              4515       4509      0.01     103      Organism-specific databases                  

   ZFIN                                 2973       2973      0.01     112      Organism-specific databases                  



Total number of cross-referenced databases: 148



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.26   Gln (Q) 3.93   Leu (L) 9.65   Ser (S) 6.61

   Arg (R) 5.53   Glu (E) 6.73   Lys (K) 5.82   Thr (T) 5.35

   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.41   Trp (W) 1.09

   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92

   Cys (C) 1.37   Ile (I) 5.93   Pro (P) 4.72   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3856 are encoded on a plasmid.



12188 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11623 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 78865