UniProtKB/Swiss-Prot protein knowledgebase release 2024_02 statistics 1. INTRODUCTION Release 2024_02 of 27-Mar-2024 of UniProtKB/Swiss-Prot contains 571282 sequence entries, curated from 297996 unique references and comprising 206678396 amino acids. 453 sequences have been added since release 2024_01, the sequence data of 59 existing entries has been updated and the annotations of 436850 entries have been revised. Number of fragments: 9301 Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 41135 Protein existence (PE): entries % 1: Evidence at protein level 114275 20% 2: Evidence at transcript level 55797 9.8% 3: Inferred from homology 386374 67.6% 4: Predicted 13011 2.3% 5: Uncertain 1825 0.3% The growth of the database is summarized below. 2. TAXONOMIC ORIGIN Total number of species represented in this release of UniProtKB/Swiss-Prot: 14604 The first twenty species represent 123014 sequences: 21.5 % of the total number of entries. 2.1 Table of the frequency of occurrence of species Species represented 1x: 5949 2x: 2124 3x: 1140 4x: 773 5x: 535 6x: 443 7x: 329 8x: 280 9x: 240 10x: 158 11- 20x: 837 21- 50x: 511 51-100x: 228 >100x: 1057 2.2 Table of the most represented species ------ --------- -------------------------------------------- Number Frequency Species ------ --------- -------------------------------------------- 1 20434 Homo sapiens (Human) 2 17207 Mus musculus (Mouse) 3 16384 Arabidopsis thaliana (Mouse-ear cress) 4 8195 Rattus norvegicus (Rat) 5 6727 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 6 6045 Bos taurus (Bovine) 7 5121 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 8 4530 Escherichia coli (strain K12) 9 4468 Caenorhabditis elegans 10 4191 Bacillus subtilis (strain 168) 11 4187 Oryza sativa subsp. japonica (Rice) 12 4159 Dictyostelium discoideum (Social amoeba) 13 3765 Drosophila melanogaster (Fruit fly) 14 3502 Xenopus laevis (African clawed frog) 15 3320 Danio rerio (Zebrafish) (Brachydanio rerio) 16 2308 Gallus gallus (Chicken) 17 2308 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 18 2218 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 19 2046 Escherichia coli O157:H7 20 1899 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 21 1824 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 22 1787 Methanocaldococcus jannaschii 23 1711 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 24 1704 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 25 1702 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 26 1696 Shigella flexneri 27 1460 Pseudomonas aeruginosa 28 1458 Sus scrofa (Pig) 29 1349 Salmonella typhi 30 1244 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 31 1176 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 32 1144 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) 33 1098 Synechocystis sp. (strain PCC 6803 / Kazusa) 34 1036 Archaeoglobus fulgidus 35 1030 Yersinia pestis 36 1016 Emericella nidulans 37 997 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 38 979 Oryctolagus cuniculus (Rabbit) 39 967 Neurospora crassa 40 942 Staphylococcus aureus (strain Mu50 / ATCC 700699) 41 930 Salmonella paratyphi A (strain ATCC 9150 / SARB42) 42 929 Staphylococcus aureus (strain N315) 43 928 Eremothecium gossypii 44 919 Kluyveromyces lactis 45 909 Acanthamoeba polyphaga mimivirus (APMV) 46 905 Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) 47 905 Staphylococcus aureus (strain COL) 48 896 Staphylococcus aureus (strain MW2) 49 894 Escherichia coli O6:K15:H31 (strain 536 / UPEC) 50 890 Staphylococcus aureus (strain MSSA476) 51 888 Candida glabrata 52 888 Staphylococcus aureus (strain MRSA252) 53 887 Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) 54 882 Salmonella choleraesuis (strain SC-B67) 55 879 Shigella sonnei (strain Ss046) 56 872 Oryza sativa subsp. indica (Rice) 57 863 Yersinia pseudotuberculosis serotype I (strain IP32953) 58 849 Zea mays (Maize) 59 847 Escherichia coli O9:H4 (strain HS) 60 847 Canis lupus familiaris (Dog) (Canis familiaris) 61 838 Escherichia coli O139:H28 (strain E24377A / ETEC) 62 829 Shigella boydii serotype 4 (strain Sb227) 63 825 Escherichia coli (strain UTI89 / UPEC) 64 822 Shigella dysenteriae serotype 1 (strain Sd197) 65 822 Escherichia coli 66 816 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 67 811 Staphylococcus aureus (strain NCTC 8325 / PS 47) 68 803 Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 69 796 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) 70 791 Escherichia coli (strain SMS-3-5 / SECEC) 71 788 Aquifex aeolicus (strain VF5) 72 779 Escherichia coli O127:H6 (strain E2348/69 / EPEC) 73 771 Escherichia coli (strain K12 / DH10B) 74 770 Pasteurella multocida (strain Pm70) 75 766 Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) 76 765 Escherichia coli (strain K12 / MC4100 / BW2952) 77 762 Escherichia coli (strain 55989 / EAEC) 78 761 Escherichia coli O8 (strain IAI1) 79 760 Shigella flexneri serotype 5b (strain 8401) 80 760 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 81 760 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 82 759 Escherichia coli O45:K1 (strain S88 / ExPEC) 83 758 Bacillus anthracis 84 756 Escherichia coli (strain SE11) 85 753 Escherichia coli O7:K1 (strain IAI39 / ExPEC) 86 749 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) 87 748 Escherichia coli O157:H7 (strain EC4115 / EHEC) 88 744 Halalkalibacterium halodurans 89 739 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) 90 734 Pseudomonas putida 91 733 Vibrio vulnificus (strain CMCP6) 92 731 Escherichia coli O81 (strain ED1a) 93 722 Salmonella enteritidis PT4 (strain P125109) 94 720 Escherichia coli 95 718 Vibrio vulnificus (strain YJ016) 96 716 Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) 97 715 Yersinia pestis bv. Antiqua (strain Nepal516) 98 715 Escherichia coli O1:K1 / APEC 99 715 Enterobacter sp. (strain 638) 100 715 Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) 101 714 Salmonella paratyphi A (strain AKU_12601) 102 713 Salmonella agona (strain SL483) 103 713 Salmonella newport (strain SL254) 104 713 Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) 105 712 Salmonella schwarzengrund (strain CVM19633) 106 711 Yersinia pestis bv. Antiqua (strain Antiqua) 107 710 Salmonella heidelberg (strain SL476) 108 707 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) 109 702 Salmonella dublin (strain CT_02021853) 110 699 Klebsiella pneumoniae (strain 342) 111 698 Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) 112 695 Escherichia fergusonii 113 692 Pan troglodytes (Chimpanzee) 114 686 Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) 115 684 Salmonella gallinarum (strain 287/91 / NCTC 13346) 116 683 Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) 117 679 Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) 118 679 Staphylococcus aureus (strain USA300) 119 672 Serratia proteamaculans (strain 568) 120 670 Bacillus cereus 121 669 Mycobacterium leprae (strain TN) 122 667 Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) 123 667 Yersinia pestis (strain Pestoides F) 124 666 Bradyrhizobium diazoefficiens 125 663 Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 126 660 Shewanella oneidensis (strain MR-1) 127 658 Sinorhizobium fredii (strain NBRC 101917 / NGR234) 128 653 Debaryomyces hansenii 129 643 Staphylococcus aureus (strain bovine RF122 / ET3-1) 130 642 Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) 131 642 Yersinia pseudotuberculosis serotype O:3 (strain YPIII) 132 634 Yersinia pseudotuberculosis serotype IB (strain PB1/+) 133 622 Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) 134 622 Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii) 135 622 Methanothermobacter thermautotrophicus 136 622 Treponema pallidum (strain Nichols) 137 620 Pseudomonas aeruginosa (strain UCBPP-PA14) 138 615 Xanthomonas campestris pv. campestris 139 614 Staphylococcus haemolyticus (strain JCSC1435) 140 613 Mesorhizobium japonicum (Mesorhizobium loti 141 612 Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) 142 605 Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262) 143 603 Ralstonia nicotianae (strain GMI1000) (Ralstonia solanacearum) 144 602 Staphylococcus saprophyticus subsp. saprophyticus 145 602 Photobacterium profundum (strain SS9) 146 601 Salmonella paratyphi C (strain RKS4594) 147 600 Yersinia pestis bv. Antiqua (strain Angola) 148 595 Bacillus cereus (strain ATCC 10987 / NRS 248) 149 591 Pectobacterium carotovorum subsp. carotovorum (strain PC1) 150 588 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 151 588 Neisseria meningitidis serogroup B (strain MC58) 152 584 Rickettsia prowazekii (strain Madrid E) 153 582 Caenorhabditis briggsae 154 579 Brucella suis biovar 1 (strain 1330) 155 576 Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) 156 575 Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus) 157 573 Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri) 158 572 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 159 571 Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) 160 569 Bacillus thuringiensis subsp. konkukian (strain 97-27) 161 568 Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) 162 568 Pseudomonas syringae pv. syringae (strain B728a) 163 565 Bacillus licheniformis 164 564 Thermotoga maritima 165 562 Bacillus cereus (strain ZK / E33L) 166 562 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 167 559 Clostridium acetobutylicum 168 557 Xanthomonas axonopodis pv. citri (strain 306) 169 555 Pseudomonas fluorescens (strain Pf0-1) 170 554 Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) 171 554 Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) 172 553 Oceanobacillus iheyensis 173 547 Pseudomonas savastanoi pv. phaseolicola (Pseudomonas syringae pv. phaseolicola 174 543 Corynebacterium glutamicum 175 540 Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) 176 531 Erwinia tasmaniensis 177 530 Listeria monocytogenes serotype 4b (strain F2365) 178 529 Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 179 529 Sodalis glossinidius (strain morsitans) 180 524 Staphylococcus aureus (strain Newman) 181 523 Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) 182 522 Xylella fastidiosa (strain 9a5c) 183 521 Deinococcus radiodurans 184 519 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 185 519 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 186 519 Chromobacterium violaceum 187 516 Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) 188 515 Xylella fastidiosa (strain Temecula1 / ATCC 700964) 189 512 Pseudomonas aeruginosa (strain PA7) 190 512 Haemophilus ducreyi (strain 35000HP / ATCC 700724) 191 512 Geobacillus kaustophilus (strain HTA426) 192 511 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) 193 511 Streptomyces avermitilis 194 508 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) 195 507 Streptococcus pneumoniae (strain ATCC BAA-255 / R6) 196 507 Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) 197 506 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 198 506 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) 199 505 Nicotiana tabacum (Common tobacco) 200 504 Pseudomonas entomophila (strain L48) 201 499 Brucella abortus biovar 1 (strain 9-941) 202 499 Haemophilus influenzae (strain 86-028NP) 203 498 Methanosarcina mazei 204 498 Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1) 205 497 Burkholderia pseudomallei (strain K96243) 206 496 Rickettsia conorii (strain ATCC VR-613 / Malish 7) 207 496 Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) 208 496 Proteus mirabilis (strain HI4320) 209 496 Shouchella clausii (strain KSM-K16) (Alkalihalobacillus clausii) 210 495 Pyrococcus horikoshii 211 494 Xanthomonas campestris pv. campestris (strain 8004) 212 493 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 213 492 Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42) 214 492 Brucella abortus (strain 2308) 215 491 Vibrio campbellii (strain ATCC BAA-1116) 216 491 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 217 487 Shewanella sp. (strain MR-7) 218 486 Mannheimia succiniciproducens (strain MBEL55E) 219 484 Shewanella sp. (strain MR-4) 220 484 Staphylococcus aureus (strain Mu3 / ATCC 700698) 221 484 Pseudomonas aeruginosa (strain LESB58) 222 483 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) 223 483 Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) 224 479 Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) 225 477 Pyrococcus abyssi (strain GE5 / Orsay) 226 476 Cupriavidus necator 227 475 Campylobacter jejuni subsp. jejuni serotype O:2 228 475 Burkholderia lata 229 472 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 230 470 Clostridium perfringens (strain 13 / Type A) 231 470 Cereibacter sphaeroides 232 470 Enterococcus faecalis (strain ATCC 700802 / V583) 233 468 Shewanella sp. (strain ANA-3) 234 468 Pseudomonas putida (strain GB-1) 235 467 Aeromonas hydrophila subsp. hydrophila 236 467 Shewanella frigidimarina (strain NCIMB 400) 237 466 Xanthomonas campestris pv. vesicatoria (strain 85-10) 238 465 Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis) 239 463 Burkholderia mallei (strain ATCC 23344) 240 461 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator 241 460 Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) 242 460 Ovis aries (Sheep) 243 457 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 244 455 Xanthomonas oryzae pv. oryzae (strain MAFF 311018) 245 455 Staphylococcus aureus (strain JH1) 246 455 Shewanella baltica (strain OS185) 247 453 Pseudomonas putida (strain W619) 248 453 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) 249 453 Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) 250 452 Aeromonas salmonicida (strain A449) 2.3 Taxonomic distribution of the sequences Kingdom sequences (% of the database) Archaea 19735 ( 3%) Bacteria 336355 ( 59%) Eukaryota 197802 ( 35%) Viruses 17390 ( 3%) Within Eukaryota: Category sequences (% of Eukaryota) (% of the complete database) Human 20435 ( 10%) ( 4%) Other Mammalia 47428 ( 24%) ( 8%) Other Vertebrata 18961 ( 10%) ( 3%) Viridiplantae 41712 ( 21%) ( 7%) Fungi 36859 ( 19%) ( 6%) Insecta 9821 ( 5%) ( 2%) Nematoda 5386 ( 3%) ( 1%) Other 17200 ( 9%) ( 3%) 3. SEQUENCE SIZE Repartition of the sequences by size (excluding fragments) From To Number From To Number 1- 50 9980 1001-1100 4131 51- 100 43589 1101-1200 2902 101- 150 59883 1201-1300 2212 151- 200 59649 1301-1400 2071 201- 250 58550 1401-1500 1680 251- 300 52486 1501-1600 835 301- 350 52953 1601-1700 647 351- 400 45975 1701-1800 593 401- 450 37743 1801-1900 507 451- 500 30609 1901-2000 398 501- 550 22333 2001-2100 273 551- 600 15854 2101-2200 387 601- 650 13169 2201-2300 340 651- 700 9413 2301-2400 235 701- 750 7885 2401-2500 197 751- 800 5703 >2500 1467 801- 850 4890 851- 900 5316 901- 950 4110 951-1000 3016 The average sequence length in UniProtKB/Swiss-Prot is 361 amino acids. The shortest sequence is GWA_SEPOF (P83570): 2 amino acids. The longest sequence is TITIN_MOUSE (A2ASS6): 35213 amino acids. 4. JOURNAL CITATIONS Note: the following citation statistics reflect the number of distinct journal citations. Total number of journals cited in this release of UniProtKB/Swiss-Prot: 3147 4.1 Table of the frequency of journal citations Journals cited 1x: 998 2x: 429 3x: 224 4x: 145 5x: 125 6x: 87 7x: 64 8x: 77 9x: 48 10x: 39 11- 20x: 244 21- 50x: 265 51-100x: 142 >100x: 260 4.2 List of the most cited journals in UniProtKB/Swiss-Prot Nb Citations Journal name -- --------- ------------------------------------------------------------- 1 27207 Journal of Biological Chemistry 2 12711 Proceedings of the National Academy of Sciences of the U.S.A. 3 7204 Journal of Bacteriology 4 6063 Biochemical and Biophysical Research Communications 5 5859 Biochemistry 6 5339 Nucleic Acids Research 7 5135 Nature 8 5099 FEBS Letters 9 4982 The EMBO Journal 10 4891 Gene 11 4592 Journal of Molecular Biology 12 4572 Molecular and Cellular Biology 13 4037 Biochimica et Biophysica Acta 14 3877 Cell 15 3604 Journal of Virology 16 3512 European Journal of Biochemistry 17 3389 Science 18 3172 Biochemical Journal 19 2861 Molecular Microbiology 20 2813 Plant Physiology 21 2611 PLoS ONE 22 2548 Genomics 23 2430 The American Journal of Human Genetics 24 2364 Journal of Cell Biology 25 2200 The Plant Cell 26 2038 The Plant Journal 27 2019 Human Molecular Genetics 28 1954 Genes and Development 29 1925 Plant Molecular Biology 30 1902 Virology 31 1852 Nature Genetics 32 1827 Molecular Biology of the Cell 33 1826 Development 34 1823 Molecular Cell 35 1692 Journal of Immunology 36 1659 Human Mutation 37 1568 Oncogene 38 1471 Structure 39 1432 Molecular and General Genetics 40 1423 Genetics 41 1419 Journal of Biochemistry 42 1391 Journal of Cell Science 43 1276 Blood 44 1272 Infection and Immunity 45 1269 Nature Communications 46 1187 Journal of General Virology 47 1184 Developmental Biology 48 1181 Microbiology 49 1156 Archives of Biochemistry and Biophysics 50 1149 Current Biology 51 1023 Applied and Environmental Microbiology 52 1023 Journal of Neuroscience 53 994 Acta Crystallographica, Section D 54 926 Cancer Research 55 917 FEMS Microbiology Letters 56 909 PLoS Genetics 57 891 Scientific Reports 58 890 Toxicon 59 884 American Journal of Physiology 60 868 Protein Science 61 854 Yeast 62 853 Journal of Clinical Investigation 63 827 Neuron 64 771 Plant and Cell Physiology 65 758 The Journal of Experimental Medicine 66 756 Human Genetics 67 710 Journal of Medical Genetics 68 695 Proteins 69 692 The FEBS Journal 70 677 PLoS Pathogens 71 676 Mechanisms of Development 72 671 Nature Structural and Molecular Biology 73 651 Nature Structural Biology 74 642 Nature Cell Biology 75 627 Bioscience, Biotechnology, and Biochemistry 76 594 Developmental Cell 77 593 Current Genetics 78 575 Journal of Neurochemistry 79 560 Antimicrobial Agents and Chemotherapy 80 554 Molecular Endocrinology 81 550 The Journal of Clinical Endocrinology and Metabolism 82 540 Endocrinology 83 518 Molecular and Biochemical Parasitology 84 509 Journal of the American Chemical Society 85 497 Cell Reports 86 496 Mammalian Genome 87 491 Experimental Cell Research 88 487 Eukaryotic Cell 89 478 RNA 90 477 Peptides 91 467 Journal of Experimental Botany 92 458 The FASEB Journal 93 457 Planta 94 457 EMBO Reports 95 448 American Journal of Medical Genetics. Part A 96 434 Immunogenetics 97 432 Molecular Pharmacology 98 428 Acta Crystallographica, Section F 99 422 Molecular Biology and Evolution 100 418 European Journal of Human Genetics 101 412 Molecular Plant-Microbe Interactions 102 411 Immunity 103 407 Journal of Molecular Evolution 104 401 Clinical Genetics 105 398 Journal of Investigative Dermatology 106 396 DNA and Cell Biology 107 392 Neurology 108 385 Biochimie 109 380 DNA Sequence 110 379 Biology of Reproduction 111 374 112 370 Comparative Biochemistry and Physiology 113 362 Virus Research 114 358 Genes to Cells 115 347 Journal of Lipid Research 116 345 Nature Immunology 117 342 Brain Research. Molecular Brain Research 118 340 The New England Journal of Medicine 119 339 PLoS Biology 120 339 Developmental Dynamics 121 335 Annals of Neurology 122 330 Applied Microbiology and Biotechnology 123 329 BMC Genomics 124 316 Journal of Medicinal Chemistry 125 314 Genome Research 126 314 European Journal of Immunology 127 308 Investigative Ophthalmology and Visual Science 128 299 Biological Chemistry Hoppe-Seyler 129 297 Journal of Human Genetics 130 283 Glycobiology 131 282 Journal of General Microbiology 132 281 Cytogenetics and Cell Genetics 133 278 Archives of Microbiology 134 274 Nature Chemical Biology 135 267 Brain 136 260 Phytochemistry 137 259 Traffic 138 258 Molecular Genetics and Metabolism 139 256 Protein Expression and Purification 140 255 Molecular Immunology 141 255 Nature Medicine 142 249 Journal of Cellular Biochemistry 143 249 Fungal Genetics and Biology 144 243 Cell Cycle 145 238 Circulation Research 146 234 DNA Research 147 233 Cell Research 148 233 Diabetes 149 227 Archives of Virology 150 224 Journal of Structural Biology 5. STATISTICS FOR SOME LINE TYPES The following table summarizes the total number of some UniProtKB/Swiss-Prot lines, as well as the number of entries with at least one such line, and the frequency of the lines. Total Number of Average Line type / subtype number entries per entry ------------------------------------ -------- --------- --------- References (RL) 1309237 2.29 Journal 1136851 475022 1.99 1 Submitted to EMBL/GenBank/DDBJ 160864 145000 0.28 2 Submitted to other databases 7800 7129 0.01 3 Book citation 1876 1853 <0.01 4 Plant Gene Register 613 600 <0.01 5 Unpublished observations 536 532 <0.01 6 Thesis 477 474 <0.01 7 Patent 214 207 <0.01 8 Worm Breeder's Gazette 6 6 <0.01 9 Total number of distinct authors cited in UniProtKB/Swiss-Prot: 468513 Total Number of Average Line type / subtype number entries per entry Rank ------------------------------------ -------- --------- --------- ---- Comments (CC) 2744184 4.80 ACTIVITY REGULATION 18671 18551 0.03 17 ALLERGEN 951 951 <0.01 26 ALTERNATIVE PRODUCTS 25904 25904 0.05 13 BIOPHYSICOCHEMICAL PROPERTIES 11525 11475 0.02 20 BIOTECHNOLOGY 2020 1960 <0.01 24 CATALYTIC ACTIVITY 341238 254929 0.60 4 CAUTION 14403 14104 0.03 18 COFACTOR 133369 121027 0.23 7 DEVELOPMENTAL STAGE 14366 14265 0.03 19 DISEASE 8340 5620 0.01 21 DISRUPTION PHENOTYPE 20930 20894 0.04 16 DOMAIN 58990 50238 0.10 9 FUNCTION 491499 467071 0.86 2 INDUCTION 25719 25624 0.05 14 INTERACTION 24188 24188 0.04 15 MASS SPECTROMETRY 7569 5848 0.01 22 MISCELLANEOUS 46108 40521 0.08 11 PATHWAY 143776 129787 0.25 6 PHARMACEUTICAL 171 164 <0.01 29 POLYMORPHISM 1504 1376 <0.01 25 PTM 64868 46197 0.11 8 RNA EDITING 636 636 <0.01 28 SEQUENCE CAUTION 45253 45182 0.08 12 SIMILARITY 519763 515425 0.91 1 SUBCELLULAR LOCATION 365513 356967 0.64 3 SUBUNIT 298357 292947 0.52 5 TISSUE SPECIFICITY 51165 50552 0.09 10 TOXIC DOSE 862 690 <0.01 27 WEB RESOURCE 6526 5535 0.01 23 Total number of comment topics: 29 Total Number of Average Line type / subtype number entries per entry Rank ------------------------------------ -------- --------- --------- ---- Features (FT) 5354463 9.37 ACT_SITE 177191 105323 0.31 9 BINDING 1220583 218291 2.14 1 CARBOHYD 124333 31657 0.22 14 CHAIN 579661 563626 1.01 2 COILED 22536 15587 0.04 25 COMPBIAS 175006 74323 0.31 10 CONFLICT 139227 48523 0.24 12 CROSSLNK 25165 9059 0.04 24 DISULFID 135999 36222 0.24 13 DNA_BIND 12198 10921 0.02 31 DOMAIN 215650 131758 0.38 8 HELIX 338046 29314 0.59 5 INIT_MET 17585 17536 0.03 26 INTRAMEM 3040 1395 0.01 34 LIPID 13848 8887 0.02 28 MOD_RES 262522 74671 0.46 7 MOTIF 47825 31128 0.08 21 MUTAGEN 97494 19999 0.17 17 NON_CONS 2680 835 <0.01 35 NON_STD 358 283 <0.01 36 NON_TER 12629 9706 0.02 30 PEPTIDE 12634 8742 0.02 29 PROPEP 15463 13210 0.03 27 REGION 321667 150253 0.56 6 REPEAT 109255 15185 0.19 15 SIGNAL 44452 44451 0.08 22 SITE 65205 35340 0.11 19 STRAND 344389 27612 0.60 4 TOPO_DOM 150563 30484 0.26 11 TRANSIT 9566 9446 0.02 32 TRANSMEM 382090 80036 0.67 3 TURN 81756 23887 0.14 18 UNSURE 5758 898 0.01 33 VAR_SEQ 53250 22665 0.09 20 VARIANT 104035 17511 0.18 16 ZN_FING 30804 13146 0.05 23 Total number of feature keys: 36 Total Number of Average Line type / subtype number entries per entry Rank Category ------------------------------------ -------- --------- --------- ---- ------------------------------------------- Cross-references (DR) 20312262 35.56 ABCD 3067 3067 0.01 124 Protocols and materials databases AGR 69276 68546 0.12 41 Organism-specific databases Allergome 2041 1312 <0.01 132 Protein family/group databases AlphaFoldDB 546993 546993 0.96 9 3D structure databases Antibodypedia 32307 32198 0.06 62 Protocols and materials databases ArachnoServer 1148 1138 <0.01 142 Organism-specific databases Araport 16404 16308 0.03 93 Organism-specific databases Bgee 61616 61612 0.11 42 Gene expression databases BindingDB 6661 6661 0.01 109 Chemistry databases BioCyc 48111 44065 0.08 53 Enzyme and pathway databases BioGRID 61424 59520 0.11 43 Protein-protein interaction databases BioGRID-ORCS 44993 44408 0.08 55 Miscellaneous databases BioMuta 20309 20283 0.04 77 Genetic variation databases BMRB 6909 6909 0.01 107 3D structure databases BRENDA 20376 18564 0.04 75 Enzyme and pathway databases CarbonylDB 1159 1159 <0.01 141 PTM databases CAZy 9657 8692 0.02 100 Protein family/group databases CCDS 49507 34662 0.09 51 Sequence databases CDD 383043 301086 0.67 15 Family and domain databases CGD 2105 2088 <0.01 131 Organism-specific databases ChEMBL 9023 8835 0.02 101 Chemistry databases ChiTaRS 29768 29723 0.05 64 Miscellaneous databases CLAE 360 357 <0.01 159 Protein family/group databases CollecTF 137 137 <0.01 164 Gene expression databases ComplexPortal 15622 8213 0.03 96 Protein-protein interaction databases COMPLUYEAST-2DPAGE 97 97 <0.01 166 2D gel databases ConoServer 967 879 <0.01 144 Organism-specific databases CORUM 5812 5812 0.01 110 Protein-protein interaction databases CPTAC 3472 1929 0.01 120 Proteomic databases CPTC 389 389 <0.01 155 Protocols and materials databases CTD 69528 68755 0.12 40 Organism-specific databases DEPOD 254 254 <0.01 162 PTM databases dictyBase 4224 4110 0.01 117 Organism-specific databases DIP 17551 17510 0.03 89 Protein-protein interaction databases DisGeNET 17011 16792 0.03 91 Organism-specific databases DisProt 1722 1716 <0.01 135 Family and domain databases DMDM 16171 16170 0.03 95 Genetic variation databases DNASU 48397 48319 0.08 52 Protocols and materials databases DOSAC-COBS-2DPAGE 145 145 <0.01 163 2D gel databases DrugBank 31177 4773 0.05 63 Chemistry databases DrugCentral 2565 2565 <0.01 126 Chemistry databases EchoBASE 4158 4158 0.01 119 Organism-specific databases eggNOG 339410 333555 0.59 16 Phylogenomic databases ELM 1814 1814 <0.01 134 Protein-protein interaction databases EMBL 1006042 558475 1.76 4 Sequence databases EMDB 74415 8511 0.13 38 3D structure databases Ensembl 114838 50415 0.20 33 Genome annotation databases EnsemblBacteria 55443 55265 0.10 46 Genome annotation databases EnsemblFungi 23157 22713 0.04 70 Genome annotation databases EnsemblMetazoa 19092 11589 0.03 84 Genome annotation databases EnsemblPlants 36895 22353 0.06 59 Genome annotation databases EnsemblProtists 5387 5132 0.01 113 Genome annotation databases EPD 23262 23262 0.04 69 Proteomic databases ESTHER 3008 3006 0.01 125 Protein family/group databases euHCVdb 55 44 <0.01 168 Organism-specific databases EvolutionaryTrace 16781 16781 0.03 92 Miscellaneous databases ExpressionAtlas 53117 53117 0.09 49 Gene expression databases FlyBase 4168 4053 0.01 118 Organism-specific databases Gene3D 739481 459031 1.29 6 Family and domain databases GeneCards 20379 20246 0.04 73 Organism-specific databases GeneID 293878 284111 0.51 22 Genome annotation databases GeneReviews 1604 1600 <0.01 136 Organism-specific databases GeneTree 57324 57316 0.10 45 Phylogenomic databases Genevisible 55284 55284 0.10 47 Gene expression databases GeneWiki 10351 10269 0.02 99 Miscellaneous databases GenomeRNAi 22301 22301 0.04 72 Miscellaneous databases GlyConnect 2372 2215 <0.01 127 PTM databases GlyCosmos 28906 28906 0.05 65 PTM databases GlyGen 22864 22864 0.04 71 PTM databases GO 3154858 547386 5.52 1 Ontologies Gramene 36895 22353 0.06 60 Genome annotation databases GuidetoPHARMACOLOGY 2206 2206 <0.01 130 Chemistry databases HAMAP 330916 327980 0.58 18 Family and domain databases HGNC 20377 20248 0.04 74 Organism-specific databases HOGENOM 427274 427274 0.75 14 Phylogenomic databases HPA 19354 19215 0.03 82 Organism-specific databases IDEAL 1100 1100 <0.01 143 Family and domain databases IMGT_GENE-DB 267 267 <0.01 161 Protein family/group databases InParanoid 163882 163882 0.29 25 Phylogenomic databases IntAct 57345 57345 0.10 44 Protein-protein interaction databases InterPro 2431424 552220 4.26 2 Family and domain databases iPTMnet 54161 54161 0.09 48 PTM databases JaponicusDB 43 43 <0.01 170 Organism-specific databases jPOST 26413 26413 0.05 66 Proteomic databases KEGG 502914 477837 0.88 12 Genome annotation databases LegioList 765 763 <0.01 149 Organism-specific databases Leproma 672 669 <0.01 150 Organism-specific databases MaizeGDB 529 525 <0.01 152 Organism-specific databases MalaCards 5676 5667 0.01 112 Organism-specific databases MANE-Select 18492 18379 0.03 86 Genome annotation databases MassIVE 19140 19140 0.03 83 Proteomic databases MaxQB 33725 33725 0.06 61 Proteomic databases MEROPS 14202 13784 0.02 97 Protein family/group databases MetOSite 3455 3455 0.01 121 PTM databases MGI 17117 17076 0.03 90 Organism-specific databases MIM 23373 16140 0.04 68 Organism-specific databases MINT 23912 23912 0.04 67 Protein-protein interaction databases MoonDB 348 348 <0.01 160 Protein family/group databases MoonProt 368 368 <0.01 157 Protein family/group databases NCBIfam 300508 277502 0.53 19 Family and domain databases neXtProt 20324 20324 0.04 76 Organism-specific databases NIAGADS 69 69 <0.01 167 Organism-specific databases OGP 373 373 <0.01 156 2D gel databases OMA 119694 119694 0.21 31 Phylogenomic databases OpenTargets 18545 18399 0.03 85 Organism-specific databases Orphanet 8177 4417 0.01 103 Organism-specific databases OrthoDB 275397 275397 0.48 23 Phylogenomic databases PANTHER 1006919 503872 1.76 3 Family and domain databases PathwayCommons 19454 19454 0.03 81 Enzyme and pathway databases PATRIC 93020 93020 0.16 36 Genome annotation databases PaxDb 153587 153587 0.27 26 Proteomic databases PCDDB 134 134 <0.01 165 3D structure databases PDB 297707 35348 0.52 21 3D structure databases PDBsum 297707 35348 0.52 20 3D structure databases PeptideAtlas 39472 39472 0.07 58 Proteomic databases PeroxiBase 792 771 <0.01 148 Protein family/group databases Pfam 839831 540898 1.47 5 Family and domain databases PharmGKB 18033 18014 0.03 88 Organism-specific databases Pharos 20224 20224 0.04 79 Miscellaneous databases PHI-base 2341 1837 <0.01 128 Miscellaneous databases PhosphoSitePlus 42129 42129 0.07 57 PTM databases PhylomeDB 115555 115555 0.20 32 Phylogenomic databases PIR 125119 114789 0.22 30 Sequence databases PIRSF 110955 109787 0.19 34 Family and domain databases PlantReactome 1320 771 <0.01 138 Enzyme and pathway databases PomBase 5129 5125 0.01 114 Organism-specific databases PRIDE 637 637 <0.01 151 Proteomic databases PRINTS 150807 129504 0.26 27 Family and domain databases PRO 98142 98141 0.17 35 Miscellaneous databases ProMEX 488 488 <0.01 154 Proteomic databases PROSITE 492563 311285 0.86 13 Family and domain databases Proteomes 508328 463514 0.89 11 Miscellaneous databases ProteomicsDB 72714 45379 0.13 39 Proteomic databases PseudoCAP 2036 2036 <0.01 133 Organism-specific databases Pumba 18207 18207 0.03 87 Proteomic databases Reactome 142445 38182 0.25 28 Enzyme and pathway databases REBASE 794 393 <0.01 147 Protein family/group databases RefSeq 597328 451992 1.05 8 Sequence databases REPRODUCTION-2DPAGE 1260 1039 <0.01 139 2D gel databases RGD 8126 8125 0.01 104 Organism-specific databases RNAct 43109 43109 0.08 56 Miscellaneous databases SABIO-RK 5745 5745 0.01 111 Enzyme and pathway databases SASBDB 867 867 <0.01 146 3D structure databases SFLD 20276 9048 0.04 78 Family and domain databases SGD 6746 6741 0.01 108 Organism-specific databases SignaLink 19959 19959 0.03 80 Enzyme and pathway databases SIGNOR 7541 7541 0.01 105 Enzyme and pathway databases SMART 205606 148368 0.36 24 Family and domain databases SMR 516981 516981 0.90 10 3D structure databases STRING 335837 335837 0.59 17 Protein-protein interaction databases SUPFAM 648318 459531 1.13 7 Family and domain databases SWISS-2DPAGE 1177 1177 <0.01 140 2D gel databases SwissLipids 1478 1394 <0.01 137 Chemistry databases SwissPalm 13349 13349 0.02 98 PTM databases TAIR 16394 16308 0.03 94 Organism-specific databases TCDB 8552 8467 0.01 102 Protein family/group databases TopDownProteomics 3236 2957 0.01 123 Proteomic databases TreeFam 46248 46225 0.08 54 Phylogenomic databases TubercuList 2329 2293 <0.01 129 Organism-specific databases UCD-2DPAGE 496 496 <0.01 153 2D gel databases UCSC 50903 46441 0.09 50 Genome annotation databases UniLectin 360 360 <0.01 158 Protein family/group databases UniPathway 139739 126099 0.24 29 Enzyme and pathway databases VEuPathDB 81664 75077 0.14 37 Organism-specific databases VGNC 4535 4521 0.01 116 Organism-specific databases WBParaSite 51 49 <0.01 169 Genome annotation databases World-2DPAGE 936 924 <0.01 145 2D gel databases WormBase 6957 5072 0.01 106 Organism-specific databases Xenbase 4745 4745 0.01 115 Organism-specific databases ZFIN 3251 3250 0.01 122 Organism-specific databases Total number of cross-referenced databases: 170 6. AMINO ACID COMPOSITION 6.1 Composition in percent for the complete database Ala (A) 8.25 Gln (Q) 3.93 Leu (L) 9.65 Ser (S) 6.65 Arg (R) 5.52 Glu (E) 6.72 Lys (K) 5.80 Thr (T) 5.36 Asn (N) 4.06 Gly (G) 7.07 Met (M) 2.41 Trp (W) 1.10 Asp (D) 5.46 His (H) 2.27 Phe (F) 3.86 Tyr (Y) 2.92 Cys (C) 1.38 Ile (I) 5.91 Pro (P) 4.74 Val (V) 6.85 Asx (B) 0.000 Glx (Z) 0.000 Xaa (X) 0.00 Legend: gray = aliphatic, red = acidic, green = small hydroxy, blue = basic, black = aromatic, white = amide, yellow = sulfur 6.2 Classification of the amino acids by their frequency Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln, Phe, Tyr, Met, His, Cys, Trp 7. MISCELLANEOUS STATISTICS 4467 entries are encoded on a mitochondrion, and 4007 are encoded on a plasmid. 12200 entries are encoded on a plastid, of which 22 are encoded on apicoplasts, 11634 on chloroplasts, 51 on organellar chromatophores, 145 on cyanelles, 149 on non-photosynthetic plastids and 199 on unspecified types of plastid. Number of entries with at least one sequence correction: 81233