UniProtKB/Swiss-Prot protein knowledgebase release 2017_02 statistics





1.  INTRODUCTION



Release 2017_02 of 15-Feb-17 of UniProtKB/Swiss-Prot contains 553655 sequence entries,

comprising 198177566 amino acids abstracted from 250714 references. 



191 sequences have been added since release 2017_01, the sequence data of

32 existing entries has been updated and the annotations of

478936 entries have been revised.



Number of fragments: 9142

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 39464





Protein existence (PE):           entries     %



1: Evidence at protein level        94730   17.1%

2: Evidence at transcript level     57857   10.5%

3: Inferred from homology          385421   69.6%

4: Predicted                        13697    2.5%

5: Uncertain                         1950    0.4%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 13379



   The first twenty species represent 118765 sequences:  21.5 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5545

                            2x: 1920

                            3x: 1050

                            4x:  667

                            5x:  490

                            6x:  403

                            7x:  285

                            8x:  238

                            9x:  230

                           10x:  131

                       11- 20x:  718

                       21- 50x:  437

                       51-100x:  216

                         >100x: 1049





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20168  Homo sapiens (Human)

       2      16847  Mus musculus (Mouse)

       3      15136  Arabidopsis thaliana (Mouse-ear cress)

       4       7978  Rattus norvegicus (Rat)

       5       6721  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       5998  Bos taurus (Bovine)

       7       5141  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4434  Escherichia coli (strain K12)

       9       4185  Bacillus subtilis (strain 168)

      10       4134  Dictyostelium discoideum (Slime mold)

      11       3852  Caenorhabditis elegans

      12       3741  Oryza sativa subsp. japonica (Rice)

      13       3440  Drosophila melanogaster (Fruit fly)

      14       3408  Xenopus laevis (African clawed frog)

      15       2991  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2281  Gallus gallus (Chicken)

      17       2219  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      18       2165  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

      19       2032  Escherichia coli O157:H7

      20       1894  Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

      21       1793  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1787  Methanocaldococcus jannaschii  

      23       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      24       1703  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      25       1690  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      26       1680  Shigella flexneri

      27       1419  Sus scrofa (Pig)

      28       1347  Salmonella typhi

      29       1305  Pseudomonas aeruginosa 

      30       1244  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      31       1171  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      32       1063  Synechocystis sp. (strain PCC 6803 / Kazusa)

      33       1027  Archaeoglobus fulgidus 

      34       1022  Yersinia pestis

      35        988  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      36        970  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      37        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      38        929  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      39        927  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      40        926  Staphylococcus aureus (strain N315)

      41        910  Kluyveromyces lactis   

      42        909  Acanthamoeba polyphaga mimivirus (APMV)

      43        899  Staphylococcus aureus (strain COL)

      44        895  Staphylococcus aureus (strain MW2)

      45        892  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      46        892  Oryctolagus cuniculus (Rabbit)

      47        889  Staphylococcus aureus (strain MSSA476)

      48        888  Staphylococcus aureus (strain MRSA252)

      49        882  Salmonella choleraesuis (strain SC-B67)

      50        878  Shigella sonnei (strain Ss046)

      51        878  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      52        873  Emericella nidulans  

      53        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      54        862  Candida glabrata   

      55        853  Neurospora crassa 

      56        841  Escherichia coli O9:H4 (strain HS)

      57        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      58        829  Shigella boydii serotype 4 (strain Sb227)

      59        825  Escherichia coli (strain UTI89 / UPEC)

      60        822  Shigella dysenteriae serotype 1 (strain Sd197)

      61        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      62        812  Canis lupus familiaris (Dog) (Canis familiaris)

      63        806  Oryza sativa subsp. indica (Rice)

      64        791  Escherichia coli (strain SMS-3-5 / SECEC)

      65        790  Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 

      66        789  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      67        784  Aquifex aeolicus (strain VF5)

      68        776  Zea mays (Maize)

      69        776  Pasteurella multocida (strain Pm70)

      70        774  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      71        771  Escherichia coli (strain K12 / DH10B)

      72        771  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      73        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      74        764  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      75        762  Escherichia coli (strain 55989 / EAEC)

      76        761  Escherichia coli O8 (strain IAI1)

      77        760  Shigella flexneri serotype 5b (strain 8401)

      78        760  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      79        760  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

      80        758  Staphylococcus epidermidis (strain ATCC 12228)

      81        757  Staphylococcus aureus (strain NCTC 8325)

      82        756  Escherichia coli (strain SE11)

      83        756  Escherichia coli O45:K1 (strain S88 / ExPEC)

      84        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      85        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      86        745  Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

      87        741  Bacillus anthracis

      88        741  Bacillus halodurans 

      89        737  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      90        733  Vibrio vulnificus (strain CMCP6)

      91        731  Escherichia coli O81 (strain ED1a)

      92        722  Salmonella enteritidis PT4 (strain P125109)

      93        718  Vibrio vulnificus (strain YJ016)

      94        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      95        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      96        715  Enterobacter sp. (strain 638)

      97        714  Escherichia coli O1:K1 / APEC

      98        714  Salmonella paratyphi A (strain AKU_12601)

      99        713  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

     100        713  Salmonella agona (strain SL483)

     101        713  Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

     102        713  Salmonella newport (strain SL254)

     103        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     104        712  Salmonella schwarzengrund (strain CVM19633)

     105        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     106        710  Salmonella heidelberg (strain SL476)

     107        702  Salmonella dublin (strain CT_02021853)

     108        698  Klebsiella pneumoniae (strain 342)

     109        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     110        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     111        693  Pan troglodytes (Chimpanzee)

     112        692  Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

     113        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     114        684  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     115        679  Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

     116        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     117        672  Staphylococcus aureus (strain USA300)

     118        670  Serratia proteamaculans (strain 568)

     119        670  Escherichia coli

     120        669  Mycobacterium leprae (strain TN)

     121        667  Yersinia pestis (strain Pestoides F)

     122        665  Bacillus cereus 

     123        661  Bradyrhizobium diazoefficiens 

     124        658  Sinorhizobium fredii (strain NBRC 101917 / NGR234)

     125        653  Debaryomyces hansenii   

     126        650  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     127        645  Shewanella oneidensis (strain MR-1)

     128        645  Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 

     129        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     130        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     131        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     132        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     133        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     134        620  Methanothermobacter thermautotrophicus  

     135        620  Treponema pallidum (strain Nichols)

     136        613  Staphylococcus haemolyticus (strain JCSC1435)

     137        610  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)

     138        608  Xanthomonas campestris pv. campestris 

     139        607  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     140        603  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     141        602  Photobacterium profundum (strain SS9)

     142        602  Staphylococcus saprophyticus subsp. saprophyticus 

     143        601  Salmonella paratyphi C (strain RKS4594)

     144        600  Yersinia pestis bv. Antiqua (strain Angola)

     145        593  Bacillus cereus (strain ATCC 10987 / NRS 248)

     146        593  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     147        592  Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)

     148        591  Pseudomonas aeruginosa (strain UCBPP-PA14)

     149        591  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     150        586  Rickettsia prowazekii (strain Madrid E)

     151        580  Neisseria meningitidis serogroup B (strain MC58)

     152        579  Brucella suis biovar 1 (strain 1330)

     153        577  Caenorhabditis briggsae

     154        573  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     155        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     156        569  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     157        568  Caulobacter crescentus (strain ATCC 19089 / CB15)

     158        568  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     159        567  Vibrio fischeri (strain ATCC 700601 / ES114)

     160        567  Pseudomonas syringae pv. syringae (strain B728a)

     161        564  Bacillus licheniformis 

     162        562  Bacillus cereus (strain ZK / E33L)

     163        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     164        559  Clostridium acetobutylicum 

     165        556  Xanthomonas axonopodis pv. citri (strain 306)

     166        553  Oceanobacillus iheyensis 

     167        553  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

     168        552  Pseudomonas fluorescens (strain Pf0-1)

     169        548  Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

     170        546  Pseudomonas savastanoi pv. phaseolicola  (Pseudomonas syringae pv. phaseolicola 

     171        546  Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

     172        543  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     173        536  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     174        531  Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

     175        529  Sodalis glossinidius (strain morsitans)

     176        529  Listeria monocytogenes serotype 4b (strain F2365)

     177        525  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     178        522  Xylella fastidiosa (strain 9a5c)

     179        518  Corynebacterium glutamicum 

     180        517  Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

     181        517  Chromobacterium violaceum 

     182        515  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     183        515  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     184        512  Deinococcus radiodurans 

     185        512  Pseudomonas aeruginosa (strain PA7)

     186        511  Staphylococcus aureus (strain Newman)

     187        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     188        509  Geobacillus kaustophilus (strain HTA426)

     189        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     190        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     191        507  Streptomyces avermitilis 

     192        501  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     193        500  Pseudomonas entomophila (strain L48)

     194        499  Brucella abortus biovar 1 (strain 9-941)

     195        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     196        496  Bacillus clausii (strain KSM-K16)

     197        495  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     198        495  Burkholderia pseudomallei (strain K96243)

     199        495  Haemophilus influenzae (strain 86-028NP)

     200        494  Proteus mirabilis (strain HI4320)

     201        494  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     202        493  Xanthomonas campestris pv. campestris (strain 8004)

     203        492  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     204        492  Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) 

     205        491  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     206        490  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     207        490  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     208        487  Methanosarcina mazei  

     209        487  Shewanella sp. (strain MR-7)

     210        486  Mannheimia succiniciproducens (strain MBEL55E)

     211        484  Pseudomonas aeruginosa (strain LESB58)

     212        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     213        484  Thermosynechococcus elongatus (strain BP-1)

     214        484  Shewanella sp. (strain MR-4)

     215        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     216        482  Pyrococcus horikoshii 

     217        482  Brucella abortus (strain 2308)

     218        479  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     219        479  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)

     220        478  Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

     221        477  Pyrococcus abyssi (strain GE5 / Orsay)

     222        474  Burkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 383)

     223        469  Nicotiana tabacum (Common tobacco)

     224        469  Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

     225        468  Clostridium perfringens (strain 13 / Type A)

     226        467  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 

     227        467  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     228        466  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     229        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     230        466  Shewanella frigidimarina (strain NCIMB 400)

     231        466  Pseudomonas putida (strain GB-1)

     232        466  Shewanella sp. (strain ANA-3)

     233        464  Aeromonas hydrophila subsp. hydrophila 

     234        464  Anabaena variabilis (strain ATCC 29413 / PCC 7937)

     235        462  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     236        462  Burkholderia mallei (strain ATCC 23344)

     237        462  Enterococcus faecalis (strain ATCC 700802 / V583)

     238        461  Campylobacter jejuni subsp. jejuni serotype O:2 

     239        459  Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha 

     240        457  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     241        457  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     242        456  Ovis aries (Sheep)

     243        455  Staphylococcus aureus (strain JH1)

     244        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     245        453  Pseudomonas putida (strain W619)

     246        452  Aeromonas salmonicida (strain A449)

     247        452  Shewanella baltica (strain OS185)

     248        451  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

     249        450  Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)

     250        450  Dechloromonas aromatica (strain RCB)





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19411 (  4%)

    Bacteria         332904 ( 60%)

    Eukaryota        184640 ( 33%)

    Viruses           16700 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20169 ( 11%)           (  4%)

     Other Mammalia         46401 ( 25%)           (  8%)

     Other Vertebrata       17985 ( 10%)           (  3%)

     Viridiplantae          38457 ( 21%)           (  7%)

     Fungi                  32598 ( 18%)           (  6%)

     Insecta                 9026 (  5%)           (  2%)

     Nematoda                4740 (  3%)           (  1%)

     Other                  15264 (  8%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9208             1001-1100     3927

                 51- 100   42178             1101-1200     2758

                101- 150   58602             1201-1300     2117

                151- 200   58599             1301-1400     1970

                201- 250   57422             1401-1500     1578

                251- 300   51085             1501-1600      772

                301- 350   51407             1601-1700      597

                351- 400   44588             1701-1800      520

                401- 450   36636             1801-1900      454

                451- 500   29483             1901-2000      366

                501- 550   21165             2001-2100      239

                551- 600   15132             2101-2200      318

                601- 650   12657             2201-2300      304

                651- 700    9132             2301-2400      197

                701- 750    7568             2401-2500      153

                751- 800    5433             >2500         1192

                801- 850    4715

                851- 900    5168

                901- 950    3999

                951-1000    2874



   





   The average sequence length in UniProtKB/Swiss-Prot is 357 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2644





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  851

                       2x:  364

                       3x:  162

                       4x:  129

                       5x:   99

                       6x:   95

                       7x:   61

                       8x:   53

                       9x:   36

                      10x:   30

                  11- 20x:  213

                  21- 50x:  214

                  51-100x:  116

                    >100x:  221





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        23640   Journal of Biological Chemistry

    2        10828   Proceedings of the National Academy of Sciences of the U.S.A.

    3         6374   Journal of Bacteriology

    4         5435   Biochemical and Biophysical Research Communications

    5         5084   Biochemistry

    6         4890   Nucleic Acids Research

    7         4766   Gene

    8         4701   FEBS Letters

    9         4567   The EMBO Journal

   10         4248   Nature

   11         4241   Molecular and Cellular Biology

   12         4098   Journal of Molecular Biology

   13         3516   Biochimica et Biophysica Acta

   14         3412   Cell

   15         3356   European Journal of Biochemistry

   16         2991   Journal of Virology

   17         2856   Science

   18         2759   Biochemical Journal

   19         2526   Genomics

   20         2408   Molecular Microbiology

   21         2372   Plant Physiology

   22         2101   Journal of Cell Biology

   23         1992   The American Journal of Human Genetics

   24         1834   The Plant Cell

   25         1806   Plant Molecular Biology

   26         1775   Genes and Development

   27         1713   Human Molecular Genetics

   28         1694   Virology

   29         1684   The Plant Journal

   30         1683   Nature Genetics

   31         1577   Development

   32         1571   Molecular Biology of the Cell

   33         1539   PLoS ONE

   34         1512   Oncogene

   35         1503   Human Mutation

   36         1412   Molecular Cell

   37         1386   Molecular and General Genetics

   38         1349   Journal of Immunology

   39         1316   Journal of Biochemistry

   40         1260   Structure

   41         1253   Genetics

   42         1165   Journal of Cell Science

   43         1111   Blood

   44         1091   Journal of General Virology

   45         1087   Infection and Immunity

   46         1026   Microbiology

   47         1011   Archives of Biochemistry and Biophysics

   48          984   Current Biology

   49          975   Developmental Biology

   50          862   Cancer Research

   51          827   Journal of Neuroscience

   52          826   Yeast

   53          825   Acta Crystallographica, Section D

   54          811   FEMS Microbiology Letters

   55          803   Applied and Environmental Microbiology

   56          737   Protein Science

   57          730   Toxicon

   58          690   Neuron

   59          687   Journal of Clinical Investigation

   60          670   Human Genetics

   61          640   Nature Structural Biology

   62          639   American Journal of Physiology

   63          636   Mechanisms of Development

   64          625   Plant and Cell Physiology

   65          596   The Journal of Experimental Medicine

   66          579   Proteins

   67          563   Current Genetics

   68          559   Journal of Medical Genetics

   69          531   Nature Cell Biology

   70          527   Molecular Endocrinology

   71          518   Bioscience, Biotechnology, and Biochemistry

   72          512   Journal of Neurochemistry

   73          502   The Journal of Clinical Endocrinology and Metabolism

   74          494   PLoS Genetics

   75          488   Mammalian Genome

   76          484   Endocrinology

   77          464   Immunogenetics

   78          459   Nature Structural and Molecular Biology

   79          453   The FEBS Journal

   80          451   Developmental Cell

   81          445   Molecular and Biochemical Parasitology

   82          437   Experimental Cell Research

   83          428   Antimicrobial Agents and Chemotherapy

   84          407   Journal of Molecular Evolution

   85          406   Eukaryotic Cell

   86          393   Peptides

   87          388   Molecular Biology and Evolution

   88          388   RNA

   89          388   Planta

   90          384   DNA and Cell Biology

   91          370   DNA Sequence

   92          350   Journal of Investigative Dermatology

   93          350   Molecular Pharmacology

   94          344   Neurology

   95          343   Comparative Biochemistry and Physiology

   96          335   Journal of the American Chemical Society

   97          335   Brain Research. Molecular Brain Research

   98          332   EMBO Reports

   99          325   Tissue Antigens

  100          321   Biology of Reproduction

  101          320   The FASEB Journal

  102          313   Journal of Experimental Botany

  103          309   Molecular Plant-Microbe Interactions

  104          309   European Journal of Human Genetics

  105          308   Immunity

  106          303   Genes to Cells

  107          301   Biochimie

  108          300   The New England Journal of Medicine

  109          300   Developmental Dynamics

  110          300   Acta Crystallographica, Section F

  111          295   Biological Chemistry Hoppe-Seyler

  112          295   Virus Research

  113          285   Genome Research

  114          285   American Journal of Medical Genetics. Part A

  115          282   Cytogenetics and Cell Genetics

  116          270   Annals of Neurology

  117          270   PLoS Pathogens

  118          267   Journal of General Microbiology

  119          260   Clinical Genetics

  120          255   European Journal of Immunology

  121          254   BMC Genomics

  122          248   Investigative Ophthalmology and Visual Science

  123          246   Nature Immunology

  124          239   Journal of Human Genetics

  125          235   Archives of Microbiology

  126          229   Applied Microbiology and Biotechnology

  127          228   Journal of Medicinal Chemistry

  128          227   DNA Research

  129          224   Nature Communications

  130          221   Journal of Cellular Biochemistry

  131          219   Glycobiology

  132          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  133          212   PLoS Biology

  134          208   Traffic

  135          208   Molecular Genetics and Metabolism

  136          206   Circulation Research

  137          205   Archives of Virology

  138          204   Cell Cycle

  139          202   Molecular Immunology

  140          201   Diabetes

  141          200   Molecular and Cellular Endocrinology

  142          199   Journal of Lipid Research

  143          196   Protein Expression and Purification

  144          190   Phytochemistry

  145          182   Molecular Genetics and Genomics

  146          179   Insect Biochemistry and Molecular Biology

  147          179   Nature Medicine

  148          178   International Journal of Cancer

  149          174   Molecular and Cellular Neuroscience

  150          173   Molecular Phylogenetics and Evolution





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1173463                 2.12                                         

   Journal                            980069     446535      1.77       1                                 

   Submitted to EMBL/GenBank/DDBJ     182933     160550      0.33       2                                 

   Submitted to other databases         7226       6704      0.01       3                                 

   Book citation                        1613       1596     <0.01       4                                 

   Plant Gene Register                   600        588     <0.01       5                                 

   Thesis                                429        426     <0.01       6                                 

   Unpublished observations              390        386     <0.01       7                                 

   Patent                                197        193     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 386058



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2443151                 4.41                                         

   ALLERGEN                              709        709     <0.01      26                                 

   ALTERNATIVE PRODUCTS                24774      24774      0.04      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        7359       7359      0.01      21                                 

   BIOTECHNOLOGY                         787        785     <0.01      25                                 

   CATALYTIC ACTIVITY                 260765     234007      0.47       5                                 

   CAUTION                             12243      12028      0.02      17                                 

   COFACTOR                           119677     109994      0.22       7                                 

   DEVELOPMENTAL STAGE                 11325      11325      0.02      19                                 

   DISEASE                              6519       4345      0.01      22                                 

   DISRUPTION PHENOTYPE                11557      11557      0.02      18                                 

   DOMAIN                              45142      39057      0.08       9                                 

   ENZYME REGULATION                   13823      13821      0.02      16                                 

   FUNCTION                           452370     433612      0.82       2                                 

   INDUCTION                           19096      19088      0.03      14                                 

   INTERACTION                         15590      15590      0.03      15                                 

   MASS SPECTROMETRY                    6251       4709      0.01      23                                 

   MISCELLANEOUS                       36018      33183      0.07      12                                 

   PATHWAY                            136419     123639      0.25       6                                 

   PHARMACEUTICAL                         99         99     <0.01      29                                 

   POLYMORPHISM                         1164       1107     <0.01      24                                 

   PTM                                 52041      39416      0.09       8                                 

   RNA EDITING                           627        627     <0.01      28                                 

   SEQUENCE CAUTION                    43674      43674      0.08      10                                 

   SIMILARITY                         501318     497183      0.91       1                                 

   SUBCELLULAR LOCATION               342715     335889      0.62       3                                 

   SUBUNIT                            268834     268647      0.49       4                                 

   TISSUE SPECIFICITY                  43615      43614      0.08      11                                 

   TOXIC DOSE                            631        585     <0.01      27                                 

   WEB RESOURCE                         8009       6790      0.01      20                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        4285538                 7.74                                         

   ACT_SITE                           159117      96973      0.29      10                                 

   BINDING                            380667     100191      0.69       2                                 

   CA_BIND                              4099       1707      0.01      36                                 

   CARBOHYD                           113331      29041      0.20      15                                 

   CHAIN                              561284     547151      1.01       1                                 

   COILED                              21703      14979      0.04      26                                 

   COMPBIAS                            58243      31241      0.11      19                                 

   CONFLICT                           133547      46680      0.24      13                                 

   CROSSLNK                            12479       6104      0.02      30                                 

   DISULFID                           119492      32677      0.22      14                                 

   DNA_BIND                            11425      10363      0.02      32                                 

   DOMAIN                             186382     114212      0.34       8                                 

   HELIX                              229713      21507      0.41       7                                 

   INIT_MET                            18377      18377      0.03      27                                 

   INTRAMEM                             2436       1067     <0.01      37                                 

   LIPID                               12789       8236      0.02      29                                 

   METAL                              362892      90571      0.66       4                                 

   MOD_RES                            239584      70608      0.43       6                                 

   MOTIF                               40698      26075      0.07      24                                 

   MUTAGEN                             60652      13618      0.11      18                                 

   NON_CONS                             2239        779     <0.01      38                                 

   NON_STD                               359        284     <0.01      39                                 

   NON_TER                             12265       9381      0.02      31                                 

   NP_BIND                            148032      82551      0.27      11                                 

   PEPTIDE                             10837       7370      0.02      33                                 

   PROPEP                              13602      11677      0.02      28                                 

   REGION                             186011      88365      0.34       9                                 

   REPEAT                             101965      14495      0.18      16                                 

   SIGNAL                              40759      40749      0.07      23                                 

   SITE                                53444      29782      0.10      21                                 

   STRAND                             239712      20269      0.43       5                                 

   TOPO_DOM                           137081      28270      0.25      12                                 

   TRANSIT                              9195       9081      0.02      34                                 

   TRANSMEM                           365322      76248      0.66       3                                 

   TURN                                55311      17439      0.10      20                                 

   UNSURE                               4371        761      0.01      35                                 

   VAR_SEQ                             51371      21663      0.09      22                                 

   VARIANT                             94584      17112      0.17      17                                 

   ZN_FING                             30168      13258      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               17809702                32.17                                                           

   Allergome                            1712       1120     <0.01     114      Protein family/group databases               

   ArachnoServer                        1146       1136     <0.01     122      Organism-specific databases                  

   Araport                             15155      15062      0.03      80      Organism-specific databases                  

   Bgee                                54997      54996      0.10      45      Gene expression databases                    

   BindingDB                            4742       4742      0.01     100      Chemistry                                    

   BioCyc                              44155      40845      0.08      52      Enzyme and pathway databases                 

   BioGrid                             48708      48237      0.09      47      Protein-protein interaction databases        

   BioMuta                             17244      17239      0.03      74      Polymorphism and mutation databases          

   BRENDA                              12805      12033      0.02      85      Enzyme and pathway databases                 

   CAZy                                 9408       8484      0.02      88      Protein family/group databases               

   CCDS                                47481      33777      0.09      48      Sequence databases                           

   CDD                                136044     130093      0.25      29      Family and domain databases                  

   CGD                                  1710       1693     <0.01     115      Organism-specific databases                  

   ChEMBL                               6219       6219      0.01      92      Chemistry                                    

   ChiTaRS                             16502      16491      0.03      78      Other                                        

   CleanEx                             30035      29394      0.05      58      Gene expression databases                    

   CollecTF                              133        133     <0.01     141      Gene expression databases                    

   COMPLUYEAST-2DPAGE                     99         98     <0.01     143      2D gel databases                             

   ConoServer                            949        866     <0.01     123      Organism-specific databases                  

   CTD                                 74015      73247      0.13      42      Organism-specific databases                  

   DEPOD                                 239        239     <0.01     139      PTM databases                                

   dictyBase                            4210       4095      0.01     104      Organism-specific databases                  

   DIP                                 17201      17145      0.03      75      Protein-protein interaction databases        

   DisGeNET                            14919      14700      0.03      81      Organism-specific databases                  

   DisProt                               699        699     <0.01     129      3D structure databases                       

   DMDM                                16370      16306      0.03      79      Polymorphism and mutation databases          

   DNASU                               18904      18831      0.03      71      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     146        146     <0.01     140      2D gel databases                             

   DrugBank                            11785       1910      0.02      86      Chemistry                                    

   EchoBASE                             4161       4161      0.01     105      Organism-specific databases                  

   EcoGene                              4294       4292      0.01     102      Organism-specific databases                  

   eggNOG                             660068     329361      1.19       5      Phylogenomic databases                       

   EMBL                               984081     542320      1.78       3      Sequence databases                           

   Ensembl                             85685      48884      0.15      40      Genome annotation databases                  

   EnsemblBacteria                    353730     334654      0.64      16      Genome annotation databases                  

   EnsemblFungi                        31021      28459      0.06      57      Genome annotation databases                  

   EnsemblMetazoa                      13710      10115      0.02      83      Genome annotation databases                  

   EnsemblPlants                       23779      19240      0.04      63      Genome annotation databases                  

   EnsemblProtists                      5022       4844      0.01      99      Genome annotation databases                  

   EPD                                 19930      19930      0.04      70      Proteomic databases                          

   ESTHER                               2462       2460     <0.01     111      Protein family/group databases               

   euHCVdb                                55         44     <0.01     145      Organism-specific databases                  

   EuPathDB                            18156      18153      0.03      73      Organism-specific databases                  

   EvolutionaryTrace                   16578      16575      0.03      77      Other                                        

   ExpressionAtlas                     36865      36865      0.07      54      Gene expression databases                    

   FlyBase                              6127       5770      0.01      94      Organism-specific databases                  

   Gene3D                             468894     348096      0.85      10      Family and domain databases                  

   GeneCards                           20336      19940      0.04      66      Organism-specific databases                  

   GeneDB                                407        368     <0.01     136      Genome annotation databases                  

   GeneID                             291223     280554      0.53      21      Genome annotation databases                  

   GeneReviews                          1156       1153     <0.01     120      Organism-specific databases                  

   GeneTree                            57798      57759      0.10      43      Phylogenomic databases                       

   Genevisible                         55171      55171      0.10      44      Gene expression databases                    

   GeneWiki                            10368      10282      0.02      87      Other                                        

   GenomeRNAi                          21923      21921      0.04      64      Other                                        

   GO                                2784781     526526      5.03       1      Ontologies                                   

   Gramene                             23779      19240      0.04      62      Genome annotation databases                  

   GuidetoPHARMACOLOGY                  2006       2006     <0.01     113      Chemistry                                    

   H-InvDB                              5587       4766      0.01      97      Organism-specific databases                  

   HAMAP                              326300     323613      0.59      18      Family and domain databases                  

   HGNC                                20108      19960      0.04      68      Organism-specific databases                  

   HOGENOM                            389775     389775      0.70      15      Phylogenomic databases                       

   HOVERGEN                            75768      75768      0.14      41      Phylogenomic databases                       

   HPA                                 27065      16800      0.05      61      Organism-specific databases                  

   IMGT_GENE-DB                          116        116     <0.01     142      Protein family/group databases               

   InParanoid                         136369     136369      0.25      28      Phylogenomic databases                       

   IntAct                              47354      47354      0.09      49      Protein-protein interaction databases        

   InterPro                          1960658     533989      3.54       2      Family and domain databases                  

   iPTMnet                             45950      45950      0.08      50      PTM databases                                

   KEGG                               503088     472856      0.91       7      Genome annotation databases                  

   KO                                 398085     397629      0.72      14      Phylogenomic databases                       

   LegioList                             765        763     <0.01     126      Organism-specific databases                  

   Leproma                               672        669     <0.01     130      Organism-specific databases                  

   MaizeGDB                              507        502     <0.01     133      Organism-specific databases                  

   MalaCards                            4234       4217      0.01     103      Organism-specific databases                  

   MaxQB                               28570      28570      0.05      60      Proteomic databases                          

   MEROPS                              12978      12977      0.02      84      Protein family/group databases               

   MGI                                 16762      16718      0.03      76      Organism-specific databases                  

   MIM                                 20155      14610      0.04      67      Organism-specific databases                  

   MINT                                31834      31834      0.06      55      Protein-protein interaction databases        

   MoonProt                               63         63     <0.01     144      Protein family/group databases               

   mycoCLAP                              356        352     <0.01     138      Protein family/group databases               

   neXtProt                            20100      20100      0.04      69      Organism-specific databases                  

   OGP                                   375        375     <0.01     137      2D gel databases                             

   OMA                                413285     413285      0.75      13      Phylogenomic databases                       

   OpenTargets                         20494      18565      0.04      65      Organism-specific databases                  

   Orphanet                             6146       3288      0.01      93      Organism-specific databases                  

   OrthoDB                            289645     289645      0.52      22      Phylogenomic databases                       

   PANTHER                            135907     132367      0.25      30      Family and domain databases                  

   PATRIC                             308421     308386      0.56      19      Genome annotation databases                  

   PaxDb                              111429     111093      0.20      34      Proteomic databases                          

   PDB                                141665      24445      0.26      26      3D structure databases                       

   PDBsum                             141665      24445      0.26      25      3D structure databases                       

   PeptideAtlas                        31116      31116      0.06      56      Proteomic databases                          

   PeroxiBase                            771        755     <0.01     125      Protein family/group databases               

   Pfam                               747610     511563      1.35       4      Family and domain databases                  

   PharmGKB                            18377      18335      0.03      72      Organism-specific databases                  

   PhosphoSitePlus                     38573      38573      0.07      53      PTM databases                                

   PhylomeDB                           95338      95338      0.17      38      Phylogenomic databases                       

   PIR                                123462     113062      0.22      33      Sequence databases                           

   PIRSF                              104557     103510      0.19      37      Family and domain databases                  

   PMAP-CutDB                           1461       1461     <0.01     116      Other                                        

   PomBase                              5133       5129      0.01      98      Organism-specific databases                  

   PRIDE                              141597     141597      0.26      27      Proteomic databases                          

   PRINTS                             133772     118115      0.24      32      Family and domain databases                  

   PRO                                 90737      90736      0.16      39      Other                                        

   ProDom                              29211      29029      0.05      59      Family and domain databases                  

   ProMEX                                445        445     <0.01     134      Proteomic databases                          

   PROSITE                            456251     293157      0.82      12      Family and domain databases                  

   ProteinModelPortal                 456971     456971      0.83      11      3D structure databases                       

   Proteomes                          474417     451059      0.86       9      Other                                        

   PseudoCAP                            1313       1304     <0.01     117      Organism-specific databases                  

   Reactome                           108918      33580      0.20      35      Enzyme and pathway databases                 

   REBASE                                409        409     <0.01     135      Protein family/group databases               

   RefSeq                             610913     465800      1.10       6      Sequence databases                           

   REPRODUCTION-2DPAGE                  1259       1038     <0.01     118      2D gel databases                             

   RGD                                  7904       7901      0.01      89      Organism-specific databases                  

   SABIO-RK                             3385       3385      0.01     106      Enzyme and pathway databases                 

   SFLD                                  731        731     <0.01     128      Family and domain databases                  

   SGD                                  6739       6734      0.01      90      Organism-specific databases                  

   SignaLink                            3014       3014      0.01     109      Enzyme and pathway databases                 

   SIGNOR                               3351       3351      0.01     107      Enzyme and pathway databases                 

   SMART                              190353     140491      0.34      23      Family and domain databases                  

   SMR                                181548     181548      0.33      24      3D structure databases                       

   STRING                             327280     327279      0.59      17      Protein-protein interaction databases        

   SUPFAM                             479483     365409      0.87       8      Family and domain databases                  

   SWISS-2DPAGE                         1180       1180     <0.01     119      2D gel databases                             

   SwissLipids                          1148       1068     <0.01     121      Chemistry                                    

   SwissPalm                            5947       5947      0.01      95      PTM databases                                

   TAIR                                13990      13936      0.03      82      Organism-specific databases                  

   TCDB                                 6268       6233      0.01      91      Protein family/group databases               

   TIGRFAMs                           292401     272370      0.53      20      Family and domain databases                  

   TopDownProteomics                    3222       2944      0.01     108      Proteomic databases                          

   TreeFam                             45052      45044      0.08      51      Phylogenomic databases                       

   TubercuList                          2183       2147     <0.01     112      Organism-specific databases                  

   UCD-2DPAGE                            508        499     <0.01     132      2D gel databases                             

   UCSC                                49382      45174      0.09      46      Genome annotation databases                  

   UniCarbKB                             584        584     <0.01     131      PTM databases                                

   UniGene                            107436      94842      0.19      36      Sequence databases                           

   UniPathway                         135782     123015      0.25      31      Enzyme and pathway databases                 

   VectorBase                            739        677     <0.01     127      Genome annotation databases                  

   WBParaSite                             32         32     <0.01     146      Genome annotation databases                  

   World-2DPAGE                          927        916     <0.01     124      2D gel databases                             

   WormBase                             5721       4400      0.01      96      Organism-specific databases                  

   Xenbase                              4424       4418      0.01     101      Organism-specific databases                  

   ZFIN                                 2828       2828      0.01     110      Organism-specific databases                  



Total number of cross-referenced databases: 146



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.26   Gln (Q) 3.93   Leu (L) 9.65   Ser (S) 6.60

   Arg (R) 5.53   Glu (E) 6.74   Lys (K) 5.82   Thr (T) 5.35

   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.41   Trp (W) 1.09

   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92

   Cys (C) 1.37   Ile (I) 5.93   Pro (P) 4.72   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3847 are encoded on a plasmid.



12188 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11623 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 78388