| power.roc.test(pROC) | Spotfire S+ Documentation |
Computes sample size, power, significance level or minimum AUC for ROC curves.
power.roc.test(...)
# One or Two ROC curves test with roc objects:
## S3 method for class 'roc':
power.roc.test(roc1, roc2, sig.level = 0.05,
power = NULL, alternative = c("two.sided", "one.sided"),
reuse.auc=TRUE, method = c("delong", "bootstrap", "obuchowski"), ...)
# One ROC curve with a given AUC:
## S3 method for class 'numeric':
power.roc.test(auc = NULL, ncontrols = NULL,
ncases = NULL, sig.level = 0.05, power = NULL, kappa = 1,
alternative = c("two.sided", "one.sided"), ...)
# Two ROC curves with the given parameters:
## S3 method for class 'list':
power.roc.test(parslist, ncontrols = NULL,
ncases = NULL, sig.level = 0.05, power = NULL, kappa = 1,
alternative = c("two.sided", "one.sided"), ...)
roc1, roc2 |
one or two “roc” object from the
roc function.
|
auc |
expected AUC. |
parslist |
a list of parameters for the two ROC curves test with
Obuchowski variance when no empirical ROC curve is known:
|
ncontrols, ncases |
number of controls and case observations available. |
sig.level |
expected significance level (probability of type I error). |
power |
expected power of the test (1 - probability of type II error). |
kappa |
expected balance between control and case observations. Must be
positive. Only for sample size determination, that is to determine
ncontrols and ncases.
|
alternative |
whether a one or two-sided test is performed. |
reuse.auc |
if TRUE (default) and the “roc” objects
contain an “auc” field, re-use these specifications for the
test. See the AUC specification section for more details.
|
method |
the method to compute variance and
covariance, either “delong”,
“bootstrap” or “obuchowski”. The first letter is
sufficient. Only for Two ROC curves power calculation. See
var and cov documentations for more
details.
|
... |
further arguments passed to or from other methods,
especially auc (with reuse.auc=FALSE or no AUC in
the ROC curve), cov and var (especially
arguments method, boot.n and boot.stratified).
Ignored (with a warning) with a parslist.
|
An object of class power.htest (such as that given by
power.t.test) with the supplied and computed values.
If one or no ROC curves are passed to power.roc.test, a one ROC
curve power calculation is performed. The function expects either
power, sig.level or auc, or both ncontrols
and ncases to be missing, so that the parameter is determined
from the others with the formula by Obuchowski et al., 2004 (formulas
2 and 3, p. 1123).
For the sample size, ncases is computed directly from formulas
2 and 3 and ncontrols is deduced with kappa.
AUC is optimized by uniroot while sig.level
and power are solved as quadratic equations.
power.roc.test can also be passed a roc object from the roc
function, but the empirical ROC will not be used, only the number of
patients and the AUC.
If two ROC curves are passed to power.roc.test, the function
will compute either the required sample size (if power is supplied),
the significance level (if sig.level=NULL and power is
supplied) or the power of a test of a difference between to AUCs
according to the formula by Obuchowski and McClish, 1997et al.
(formulas 2 and 3, p. 1530–1531). The null hypothesis is that the AUC
of roc1 is the same than the AUC of roc2, with
roc1 taken as the reference ROC curve.
For the sample size, ncases is computed directly from formula 2
and ncontrols is deduced from the ratio observed in roc1 and roc2.
sig.level and power are solved as quadratic equations.
The variance and covariance of the ROC curve are computed with the
var and cov functions. By default, DeLong
method is used for full AUCs and the bootstrap for partial AUCs. It is
possible to force the use of Obuchowski's variance by specifying
method="obuchowski".
Alternatively when no empirical ROC curve is known, or if only one is
available, a list can be passed to power.roc.test, with the
contents defined in the “Arguments” section. The variance and
covariance are computed from Table 1 and Equation 4 and 5 of
Obuchowski and McClish (1997), p. 1530–1531.
Power calculation for unpaired ROC curves is not implemented.
The comparison of the AUC of the ROC curves needs a specification of the AUC. The specification is defined by:
reuse.auc is set to TRUE (default)
auc with ...
(arguments partial.auc, partial.auc.correct and
partial.auc.focus). In this case, you must ensure either that
the roc object do not contain an auc field (if
you called roc with auc=FALSE), or set
reuse.auc=FALSE.
If reuse.auc=FALSE the auc function will always
be called with ... to determine the specification, even if
the “roc” objects do contain an auc field.
As well if the “roc” objects do not contain an auc
field, the auc function will always be called with
... to determine the specification.
Warning: if the roc object passed to roc.test contains an auc
field and reuse.auc=TRUE, auc is not called and
arguments such as partial.auc are silently ignored.
The authors would like to thank Christophe Combescure and Anne-Sophie Jannot for their help with the implementation of this section of the package.
Nancy A. Obuchowski, Donna K. McClish (1997). ``Sample size determination for diagnostic accurary studies involving binormal ROC curve indices''. Statistics in Medicine, 16(13), 1529–1542. DOI: href{http://dx.doi.org/10.1002/(SICI)1097-0258(19970715)16:13<1529::AID-SIM565>3.0.CO;2-H}{(SICI)1097-0258(19970715)16:13<1529::AID-SIM565>3.0.CO;2-H}.
Nancy A. Obuchowski, Micharl L. Lieber, Frank H. Wians Jr. (2004). ``ROC Curves in Clinical Chemistry: Uses, Misuses, and Possible Solutions''. Clin Chem, 50(7), 1118–1125. DOI: href{http://dx.doi.org/10.1373/clinchem.2004.031823}{10.1373/clinchem.2004.031823}.
data(aSAH) #### One ROC curve #### # Build a roc object: rocobj <- roc(aSAH$outcome, aSAH$s100b) # Determine power of one ROC curve: power.roc.test(rocobj) # Same as: power.roc.test(ncases=41, ncontrols=72, auc=0.73, sig.level=0.05) # sig.level=0.05 is implicit and can be omitted: power.roc.test(ncases=41, ncontrols=72, auc=0.73) # Determine ncases & ncontrols: power.roc.test(auc=rocobj$auc, sig.level=0.05, power=0.95, kappa=1.7) power.roc.test(auc=0.73, sig.level=0.05, power=0.95, kappa=1.7) # Determine sig.level: power.roc.test(ncases=41, ncontrols=72, auc=0.73, power=0.95, sig.level=NULL) # Derermine detectable AUC: power.roc.test(ncases=41, ncontrols=72, sig.level=0.05, power=0.95) #### Two ROC curves #### ### Full AUC roc1 <- roc(aSAH$outcome, aSAH$ndka) roc2 <- roc(aSAH$outcome, aSAH$wfns) ## Sample size # With DeLong variance (default) power.roc.test(roc1, roc2, power=0.9) # With Obuchowski variance power.roc.test(roc1, roc2, power=0.9, method="obuchowski") ## Power test # With DeLong variance (default) power.roc.test(roc1, roc2) # With Obuchowski variance power.roc.test(roc1, roc2, method="obuchowski") ## Significance level # With DeLong variance (default) power.roc.test(roc1, roc2, power=0.9, sig.level=NULL) # With Obuchowski variance power.roc.test(roc1, roc2, power=0.9, sig.level=NULL, method="obuchowski") ### Partial AUC roc3 <- roc(aSAH$outcome, aSAH$ndka, partial.auc=c(1, 0.9)) roc4 <- roc(aSAH$outcome, aSAH$wfns, partial.auc=c(1, 0.9)) ## Sample size # With bootstrap variance (default) power.roc.test(roc3, roc4, power=0.9) # With Obuchowski variance power.roc.test(roc3, roc4, power=0.9, method="obuchowski") ## Power test # With bootstrap variance (default) power.roc.test(roc3, roc4) # This is exactly equivalent: power.roc.test(roc1, roc2, reuse.auc=FALSE, partial.auc=c(1, 0.9)) # With Obuchowski variance power.roc.test(roc3, roc4, method="obuchowski") ## Significance level # With bootstrap variance (default) power.roc.test(roc3, roc4, power=0.9, sig.level=NULL) # With Obuchowski variance power.roc.test(roc3, roc4, power=0.9, sig.level=NULL, method="obuchowski") ## With only binormal parameters given # From example 2 of Obuchowski and McClish, 1997. ob.params <- list(A1=2.6, B1=1, A2=1.9, B2=1, rn=0.6, ra=0.6, FPR11=0, FPR12=0.2, FPR21=0, FPR22=0.2, delta=0.037) power.roc.test(ob.params, power=0.8, sig.level=0.05) power.roc.test(ob.params, power=0.8, sig.level=NULL, ncases=107) power.roc.test(ob.params, power=NULL, sig.level=0.05, ncases=107)