Variant position: 7 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 239 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MAHAGR TGYDNREIVMKYIHYKLSQRG
Mouse MAQAGR TGYDNREIVMKYIHYKLSQRG
Rat MAQAGR TGYDNREIVMKYIHYKLSQRG
Bovine MAHAGG TGYDNREIVMKYIHYKLSQRG
Dog MAQAGR TGYDNREIVMKYIHYKLSQRG
Chicken MAHPGR RGYDNREIVLKYIHYKLSQRG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 239 Apoptosis regulator Bcl-2
Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.
Seto M.; Jaeger U.; Hockett R.D.; Graninger W.; Bennett S.; Goldman P.; Korsmeyer S.J.;
EMBO J. 7:123-131(1988)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA); VARIANT SER-7;
Consequences of the t(14;18) chromosomal translocation in follicular lymphoma: deregulated expression of a chimeric and mutated BCL-2 gene.
Hua C.; Zorn S.; Jensen J.P.; Coupland R.W.; Ko H.S.; Wright J.J.; Bakhshi A.;
Oncogene Res. 2:263-275(1988)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]; VARIANT SER-7;
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy.
Wei Y.; Pattingre S.; Sinha S.; Bassik M.; Levine B.;
Mol. Cell 30:678-688(2008)
Cited for: PHOSPHORYLATION AT THR-69; SER-70 AND SER-87 BY MAPK8/JNK1; FUNCTION;
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