Variant position: 301 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 453 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GRTSTADYAMFKVGPEADKY RLTYAYFAGGDAGDAFDGFDF
Mouse GRTSTADYAMFRVGPESDKY RLTYAYFIGGDAGDAFDGYDF
Rat GRTSTADYAMFRVGPESDKY RLTYAYFIGGDAGDAFDGYDF
Bovine GRTSTADYASFKVTGENDKY RLTYAYFIGGDAGDAFDGYDF
Xenopus laevis NQKSTADYSTFRLGSEKDNY RFTYAYFIGGDAGDAFDGFDF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Abnormal polymerization and normal binding of plasminogen and t-PA in three new dysfibrinogenaemias: Barcelona III and IV (gamma Arg 275-->His) and Villajoyosa (gamma Arg 275-->Cys).
Borrell M.; Gari M.; Coll I.; Vallve C.; Tirado I.; Soria J.M.; Sala N.; Munoz C.; Oliver A.; Garcia A.;
Blood Coagul. Fibrinolysis 6:198-206(1995)
Cited for: PROTEIN SEQUENCE OF 291-310; VARIANTS BARCELONA-3/BARCELONA-4 HIS-301 AND VILLAJOYOSA CYS-301;
Heterozygous abnormal fibrinogen Osaka III with the replacement of gamma arginine-275 by histidine has an apparently higher molecular weight gamma-chain variant.
Yoshida N.; Imoka S.; Hirata H.; Matsuda M.; Asakura S.;
Thromb. Haemost. 68:534-538(1992)
Cited for: VARIANT OSAKA-3 HIS-301;
Three abnormal fibrinogen variants with the same amino acid substitution (gamma 275 Arg-->His): fibrinogens Bergamo II, Essen and Perugia.
Reber P.; Furlan M.; Henschen A.; Kaudewitz H.; Barbui T.; Hilgard P.; Nenci G.G.; Berrettini M.; Beck E.A.;
Thromb. Haemost. 56:401-406(1986)
Cited for: VARIANT BERGAMO-2/ESSEN/HAIFA/PERUGIA HIS-301;
Normal plasmic cleavage of the gamma-chain variant of 'fibrinogen Saga' with an Arg-275 to His substitution.
Yamazumi K.; Terukina S.; Onohara S.; Matsuda M.;
Thromb. Haemost. 60:476-480(1988)
Cited for: VARIANT SAGA HIS-301;
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