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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P02679: Variant p.Asp356Val

Fibrinogen gamma chain
Gene: FGG
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Variant information Variant position: help 356 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance
Residue change: help From Aspartate (D) to Valine (V) at position 356 (D356V, p.Asp356Val). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and acidic (D) to medium size and hydrophobic (V) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -3 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page
Variant description: help In DYSFIBRIN; fibrinogen Milano-1; impaired polymerization. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 356 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 453 The length of the canonical sequence.
Location on the sequence: help MQFSTWDNDNDKFEGNCAEQ D GSGWWMNKCHAGHLNGVYYQ The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences. 
Human                         MQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQ

Mouse                         MQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYHQ

Rat                           MHFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQ

Bovine                        MQFSTWDSDNDKYDGNCAEQVGIGWWMNKCHAGHLNGVYYQ

Xenopus laevis                MQFSTFDKDNDKFDGNCAEQDGSGWWMNRCHAAHLNGKYYQ
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 27 – 453 Fibrinogen gamma chain
Domain 170 – 416 Fibrinogen C-terminal
Binding site 344 – 344
Binding site 346 – 346
Binding site 348 – 348
Binding site 350 – 350
Disulfide bond 352 – 365
Helix 352 – 356



Literature citations
Characterization of fibrinogen Milano I: amino acid exchange gamma 330 Asp-->Val impairs fibrin polymerization.
Reber P.; Furlan M.; Rupp C.; Kehl M.; Henschen A.; Mannucci P.M.; Beck E.A.;
Blood 67:1751-1756(1986)
Cited for: VARIANT DYSFIBRIN VAL-356;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.