Variant position: 401 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 453 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SKAST-PNGYDNGIIWATWKT RWYSMKKTTMKIIPFNRLTIG
Mouse SKSST-TNGFDDGIIWATWKS RWYSMKETTMKIIPFNRLSI
Rat SKSST-PNGYDNGIIWATWKT RWYSMKETTMKIIPFNRLSI
Bovine SKTST-PNGYDNGIIWATWKS RWYSMKKTTMKIIPLNRLAI
Xenopus laevis SEADSGPSGYDNGIIWATWRR RWYSMKSVTMKIMPLNRY--
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
27 – 453 Fibrinogen gamma chain
170 – 416 Fibrinogen C-terminal
400 – 422 Gamma-chain polymerization, binding amino end of another fibrin alpha chain
Characterization of an abnormal fibrinogen Osaka V with the replacement of gamma-arginine 375 by glycine. The lack of high affinity calcium binding to D-domains and the lack of protective effect of calcium on fibrinolysis.
Yoshida N.; Hirata H.; Morigami Y.; Imaoka S.; Matsuda M.; Yamazumi K.; Asakura S.;
J. Biol. Chem. 267:2753-2759(1992)
Cited for: VARIANT OSAKA-5 GLY-401;
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