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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P69905: Variant p.Lys17Met

Hemoglobin subunit alpha
Gene: HBA2
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Variant information Variant position: help 17 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Lysine (K) to Methionine (M) at position 17 (K17M, p.Lys17Met). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from large size and basic (K) to medium size and hydrophobic (M) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In Harbin; slightly unstable. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 17 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 142 The length of the canonical sequence.
Location on the sequence: help MVLSPADKTNVKAAWG K VGAHAGEYGAEALERMFLSF The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSF

Gorilla                       -VLSPADKTNVKAAWGKVGAHAGDYGAEALERMFLSF

                              -VLSPADKTNIKSTWDKIGGHAGDYGGEALDRTFQSF

Rhesus macaque                MVLSPADKSNVKAAWGKVGGHAGEYGAEALERMFLSF

Chimpanzee                    MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSF

Mouse                         MVLSGEDKSNIKAAWGKIGGHGAEYGAEALERMFASF

Rat                           MVLSADDKTNIKNCWGKIGGHGGEYGEEALQRMFAAF

Pig                           -VLSAADKANVKAAWGKVGGQAGAHGAEALERMFLGF

Bovine                        MVLSAADKGNVKAAWGKVGGHAAEYGAEALERMFLSF

Rabbit                        MVLSPADKTNIKTAWEKIGSHGGEYGAEAVERMFLGF

Sheep                         MVLSAADKSNVKAAWGKVGGNAGAYGAEALERMFLSF

Cat                           -VLSAADKSNVKACWGKIGSHAGEYGAEALERTFCSF

Horse                         MVLSAADKTNVKAAWSKVGGHAGEYGAEALERMFLGF

Chicken                       MVLSAADKNNVKGIFTKIAGHAEEYGAETLERMFTTY

Xenopus tropicalis            MHLTADDKKHIKAIWPSVAAHGDKYGGEALHRMFMCA

Zebrafish                     MSLSDTDKAVVKAIWAKISPKADEIGAEALARMLTVY

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Initiator methionine 1 – 1 Removed
Chain 2 – 142 Hemoglobin subunit alpha
Site 12 – 12 Not glycated
Modified residue 4 – 4 Phosphoserine
Modified residue 8 – 8 N6-succinyllysine; alternate
Modified residue 9 – 9 Phosphothreonine
Modified residue 12 – 12 N6-succinyllysine
Modified residue 17 – 17 N6-acetyllysine; alternate
Modified residue 17 – 17 N6-succinyllysine; alternate
Modified residue 25 – 25 Phosphotyrosine
Modified residue 36 – 36 Phosphoserine
Glycosylation 8 – 8 N-linked (Glc) (glycation) lysine; alternate
Glycosylation 17 – 17 N-linked (Glc) (glycation) lysine; alternate
Helix 5 – 18



Literature citations
Hemoglobin Chongqing [alpha 2(NA2)Leu-->Arg] and hemoglobin Harbin [alpha 16(A14)Lys-->Met] found in China.
Zeng Y.-T.; Huang S.-Z.; Qiu X.-K.; Cheng G.-C.; Ren Z.-R.; Jin Q.-C.; Chen C.-Y.; Jiao C.-T.; Tang Z.-G.; Liu R.-H.; Bao X.-H.; Zeng L.-Z.; Duan Y.-Q.; Zhang G.-Y.;
Hemoglobin 8:569-581(1984)
Cited for: VARIANTS ARG-3 AND MET-17;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.